Can a lower drug dose improve life after stem cell transplant for older adults?
NCT ID NCT06799195
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study is for adults aged 60 and older with blood cancers who need a stem cell transplant. It compares a standard high dose of a drug (cyclophosphamide) with a lower dose, both combined with another drug (sirolimus), to prevent graft-versus-host disease (GVHD). The goal is to see if the lower dose helps patients feel better and have a higher quality of life after transplant.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Cyclophosphamide (attenuated dose) and Sirolimus
- What this could lead to
- If successful, this could lead to a safer way to prevent graft-versus-host disease after stem cell transplants, improving quality of life for older adults with blood cancers.
- What could go wrong
- This is a small, early-phase trial, so results may not apply to all patients. The lower drug dose might not prevent GVHD as effectively, and side effects are still possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198, United States
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