CHRONIC LIMB-THREATENING ISCHEMIA

This study is observing how well a special drug-coated balloon works to open blocked arteries below the knee in patients with severe leg pain or wounds that won't heal. It will follow 1,000 patients for a year to see if the procedure improves blood flow, helps wounds heal, and pr…

This study is testing a new dissolving scaffold device that slowly releases medication to keep leg arteries open. It's for people with severe leg pain or wounds due to poor circulation who are at risk of amputation. Researchers will compare this new device to standard treatments …

This study compares two different methods doctors use when opening blocked arteries in the lower legs of patients with severe circulation problems and non-healing wounds. One method uses standard imaging (angiography), while the other adds a special pressure-measuring wire to get…

This study is observing a procedure that uses sound waves (shockwaves) to break up hardened blockages in leg arteries. It aims to see if this helps heal foot wounds and prevents the need for amputation in 400 people with severe, painful leg circulation problems. Researchers will …

This study is testing whether specific leg exercises can improve blood circulation and walking ability in older adults who have poor leg circulation or chronic wounds. Researchers will compare three different exercise programs over 12 weeks to see which works best. The goal is to…

This study is testing a new surgical procedure for people with a severe leg circulation condition called chronic limb-threatening ischemia. For patients who have no other treatment options left and face amputation, this surgery aims to improve blood flow to help foot wounds heal.…

This study is testing whether using a special ultrasound device to check blood flow during leg bypass surgery leads to better long-term results. It will involve 450 patients with severe leg artery disease who are at risk of amputation. The main goal is to see if this real-time ch…

This study is testing a new injectable medicine called APAC, which is designed to prevent dangerous blood clots. It aims to see if APAC is safe and to find the best dose for people with severely blocked arteries in their legs, a condition that can lead to amputation. The study wi…

This study is monitoring the real-world safety and effectiveness of the Esprit BTK device, a small, dissolving scaffold placed in leg arteries. It aims to improve blood flow in patients with severe leg pain or non-healing wounds caused by blocked arteries below the knee. The goal…

This study aims to better understand the processes that cause artery blockages in people with leg pain from poor circulation. Researchers will perform full-body scans on 100 participants to see how inflammation and calcification in leg arteries relate to plaque in other arteries,…