CHRONIC LIMB-THREATENING ISCHEMIA

This study tests a new device called the MAGNITUDE BRS System, a temporary scaffold that slowly releases medicine to keep leg arteries open. It is for people with chronic limb-threatening ischemia, a serious condition where narrowed arteries in the leg can lead to pain, wounds, o…

This study is testing a drug-coated balloon to open blocked arteries below the knee in people with severe leg artery disease that threatens the limb. The goal is to improve blood flow, reduce pain, and avoid the need for amputation. About 1,000 participants will be followed for o…

This study tests a new medicine called APAC that aims to prevent blood clots in people with blocked leg arteries. It includes 42 adults aged 45-85 with severe disease, some of whom will have a procedure to restore blood flow. The goal is to see if APAC is safe and well tolerated,…

This study tests a new procedure that reroutes blood flow through a leg vein to save the limb in people with severe, late-stage blocked leg arteries (chronic limb-threatening ischemia). About 100 participants with non-healing wounds or gangrene will receive the LimFlow device. Th…

This study compares two methods to guide balloon treatment for blocked leg arteries in people with chronic limb-threatening ischemia (severe pain or wounds). One method uses standard X-ray images; the other adds a thin pressure wire to measure blood flow. The goal is to see which…

This study looks at a treatment called intravascular lithotripsy (IVL) that uses sound waves to break up calcium deposits in leg arteries. It aims to help wounds heal and prevent amputation in people with chronic limb-threatening ischemia, a severe form of peripheral artery disea…

This study tests a new surgery called transverse tibial bone transport for people with severe leg artery disease who have no other treatment options. The goal is to improve blood flow, heal wounds, and prevent major amputation. Ten participants will be followed to see if the proc…

This study tests three types of leg exercises (leg press, vibration, or mixed) to see which best improves blood flow and walking ability in older adults with poor circulation or chronic wounds. 425 participants will exercise 3 times a week for 12 weeks. The goal is to find a safe…

This study looks at whether using special tools to measure blood flow and take ultrasound images during leg bypass surgery can help predict how well the bypass will work over time. It involves 450 people with severe leg artery disease who are at risk of losing a limb. The goal is…

This study aims to understand how inflammation, tiny calcium deposits, and blood clots behave in the leg arteries of people with peripheral artery disease (PAD). About 100 adults with PAD will receive three different PET scans to measure these activities. The results will help re…