CHRONIC LIMB-THREATENING ISCHEMIA

This study tests whether taking two blood thinners (aspirin and clopidogrel) for 12 months after leg artery surgery is better than taking them for just 1 month in people with severe leg artery disease. The goal is to see if longer treatment prevents amputations or death. About 61…

This study compares a paclitaxel-coated balloon to a standard balloon for opening blocked arteries below the knee in people with chronic limb-threatening ischemia, a serious condition that can lead to amputation. About 288 participants will be randomly assigned to one of the two …

This study tests whether using a tiny ultrasound camera inside the leg arteries during a procedure to open blockages can prevent major problems like amputation or the artery narrowing again. About 772 adults with severe peripheral artery disease (chronic limb-threatening ischemia…

This study is testing a device that uses sound waves to break up calcium buildup in leg arteries of people with chronic limb-threatening ischemia (CLTI), a severe form of peripheral artery disease. Researchers will track 400 patients to see if the treatment helps wounds heal and …

This study is testing a device called the LimFlow Stent Graft System for people with late-stage chronic limb-threatening ischemia, a severe form of peripheral artery disease where blood flow to the leg is critically low. The device creates a new connection between a vein and arte…

This study tests a new drug called APAC, which is designed to prevent blood clots in people with blocked leg arteries. The trial includes 42 adults with peripheral arterial disease or chronic limb-threatening ischemia. Researchers will check if APAC is safe and well-tolerated, an…

This study is tracking 1,000 people with severe leg artery disease (chronic limb-threatening ischemia) who are getting a drug-coated balloon to open blocked arteries below the knee. The balloon releases a drug (paclitaxel) to help keep the artery open. Researchers want to see if …

This study tests a new type of stent that slowly dissolves and releases medication to keep leg arteries open. It is for people with chronic limb-threatening ischemia, a serious condition where blocked arteries can lead to amputation. About 300 participants will be randomly assign…

This study compares two methods for opening blocked arteries in the lower leg in people with chronic limb-threatening ischemia, a severe condition that can lead to amputation. One group gets standard balloon angioplasty guided by X-ray images (angiography). The other group uses a…

This study looks at whether different exercise programs can improve blood flow in the legs of older adults with poor circulation. About 425 participants will be split into groups doing either mixed exercise, high-intensity rowing, or vibration exercise for 12 weeks. The goal is t…

This study tracks 98 people with peripheral artery disease who had a stent placed in their iliac artery. Researchers want to see which patients later develop serious limb complications, like needing another procedure or amputation. They will also check if frailty plays a role. Th…

This study tests a new device called the Spur scaffold, used with a drug-coated balloon, to treat blocked arteries below the knee in people with chronic limb-threatening ischemia (CLTI). The study includes 40 high-risk patients—those with diabetes or on dialysis—and measures how …

This observational study aims to better understand what happens inside artery plaques in people with peripheral artery disease (PAD). Researchers will use special PET-CT scans to look for signs of inflammation, calcium buildup, and blood clots in the legs and other parts of the b…

This study looks at whether using special tools to measure blood flow and take ultrasound images during leg bypass surgery can help predict how well the graft will work over time. It involves 450 people with severe leg artery disease who are having a vein bypass below the knee. T…