CHRONIC LIMB-THREATENING ISCHEMIA
Clinical trials for CHRONIC LIMB-THREATENING ISCHEMIA explained in plain language.
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New Wound-Focused blood flow technique could save more legs from amputation
Disease control Not yet recruitingThis study tests whether a new approach called 'woundsome revascularization'—which focuses on restoring blood flow directly to the wound area—can help save the legs of 50 people with chronic limb-threatening ischemia, the most severe form of peripheral artery disease. Participant…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Phase: NA • Sponsor: Assiut University • Aim: Disease control
Last updated May 17, 2026 13:00 UTC
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Old gout drug may prevent amputation in severe leg artery disease
Disease control Not yet recruitingThis study tests whether a low dose of colchicine, a safe anti-inflammatory drug used for gout, can help people with severe leg artery disease avoid amputation or death. About 200 adults in Taiwan who recently had a procedure to restore leg blood flow will take either colchicine …
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Phase: PHASE3 • Sponsor: Shin Kong Wu Ho-Su Memorial Hospital • Aim: Disease control
Last updated May 17, 2026 12:45 UTC
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Spinning tool could save legs: new study tests orbital atherectomy for severe artery disease
Disease control Not yet recruitingThis study will follow 250 people with chronic limb-threatening ischemia (CLTI) to see how well a procedure called orbital atherectomy works in real life. The procedure uses a tiny spinning device to remove hard calcium from leg arteries, helping other treatments like balloons or…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Sponsor: Cardiovascular and Interventional Radiological Society of Europe • Aim: Disease control
Last updated May 13, 2026 16:03 UTC
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New dissolving stents could save legs from amputation
Disease control Not yet recruitingThis study tests a special dissolving scaffold coated with a drug to keep leg arteries open in 400 people with severe limb-threatening ischemia. The scaffold releases medicine to prevent re-blockage and then dissolves over time, avoiding permanent metal stents. The goal is to imp…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Sponsor: Cardiovascular and Interventional Radiological Society of Europe • Aim: Disease control
Last updated May 13, 2026 16:00 UTC
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New scaffold device aims to save legs in High-Risk patients
Disease control Not yet recruitingThis study tests a temporary scaffold system for leg arteries in 40 patients with severe leg disease (chronic limb-threatening ischemia) who are at high risk due to diabetes or dialysis. The scaffold is removed after treatment, and a drug-coated balloon is used to improve blood f…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Sponsor: Medical University of Graz • Aim: Disease control
Last updated Apr 30, 2026 15:50 UTC
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Blood test may reveal new way to treat blocked leg arteries
Knowledge-focused Not yet recruitingThis observational study looks at whether a receptor called GLP1R on blood cells differs between people with mild versus severe peripheral artery disease. Researchers will collect one extra blood sample from 50 adults during routine care to measure this receptor and related infla…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated May 17, 2026 12:46 UTC