Could a diabetes drug and a blood pressure pill shield vasculitis patients from heart attacks?
NCT ID NCT06887062
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether two drugs—bosentan and dapagliflozin—can improve blood vessel function in people with large vessel vasculitis, a condition that damages arteries and raises the risk of heart attacks and strokes. Sixty adults with stable disease will take both drugs for 6 weeks, then dapagliflozin alone for 4 weeks. Researchers will measure changes in blood flow and blood pressure to see if the combination helps protect the cardiovascular system.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Bosentan and dapagliflozin
- What this could lead to
- If it works, this could point toward a new way to lower heart attack and stroke risk in people with large vessel vasculitis.
- What could go wrong
- This is a small, early-phase trial with only 60 participants and no placebo group, so results may not be conclusive. The drugs may cause side effects like liver issues or low blood pressure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for GIANT CELL ARTERITIS (GCA) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Edinburgh
RECRUITINGEdinburgh, EH16 4TJ, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Immune clues in the blood may foretell heart trouble
- Can frequent CRP checks prevent relapses in giant cell arteritis?
- Ultrasound clue vanishes days after steroids start in artery disease
- Rare artery disease linked to higher heart attack and stroke risk
- New Total-Body PET scanner could revolutionize vasculitis diagnosis
- 5,000 patients to help unlock secrets of inflammatory heart disease