Less fluid, fewer complications? trial tests new strategy in liver transplants
NCT ID NCT07695363
First seen Jul 10, 2026 · Last updated Jul 10, 2026
Summary
This trial compares two ways of managing fluids during liver transplant surgery in adults with end-stage liver disease. One strategy limits fluids and uses medications to maintain blood pressure, while the other gives more fluids to optimize heart function. The goal is to see which approach leads to fewer severe complications and better recovery after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Low-splanchnic blood volume restrictive fluid management strategy (with phlebotomy) vs. cardiac output optimized liberal fluid management strategy
- What this could lead to
- If successful, this could establish a better way to manage fluids during liver transplant surgery, reducing severe complications and improving recovery for patients.
- What could go wrong
- This is a large trial, but results may not apply to all transplant patients or centers. The restrictive strategy carries risks like low blood pressure or organ strain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Centre hospitalier de l'Université de Montréal (CHUM)
RECRUITINGMontreal, Quebec, H2X 0C1, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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London Health Sciences Centre (LHSC)
RECRUITINGLondon, Ontario, N6G 2V4, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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McGill University Health Centre (MUHC)
RECRUITINGMontreal, Quebec, H4A 3J1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Vancouver General Hospital (VGH)
RECRUITINGVancouver, British Columbia, V5Z 1M9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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