Liver biopsy during machine perfusion may reveal organ viability before transplant
NCT ID NCT07674394
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This study investigates whether examining liver tissue during a cold preservation technique called hypothermic oxygenated machine perfusion can help predict how well the organ will work after transplant. Researchers will compare biopsies taken before and after perfusion and analyze fluid markers of cell damage. The goal is to develop a tool, possibly using artificial intelligence, to better assess donor liver quality and improve transplant safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Hypothermic Oxygenated Machine Perfusion (HOPE/D-HOPE)
What this could lead to
If successful, this could lead to a reliable way to assess donor liver quality before transplant, helping doctors decide which organs are safe to use and potentially increasing the number of successful transplants.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly improve outcomes. The findings may not apply to all liver types or transplant centers, and the biomarkers might not predict results accurately enough for clinical use.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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ASST Grande Ospedale Metropolitano Niguarda
Milan, 20162, Italy
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Azienda Ospedaliera San Camillo Forlanini
Roma, 00152, Italy
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IRCCS ISMETT - Istituto Mediterraneo per i Trapianti e le Terapie ad Alta Specializzazione,
Palermo, 90127, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••