Liver biopsy during machine perfusion may reveal organ viability before transplant
NCT ID NCT07674394
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This study investigates whether examining liver tissue during a cold preservation technique called hypothermic oxygenated machine perfusion can help predict how well the organ will work after transplant. Researchers will compare biopsies taken before and after perfusion and analyze fluid markers of cell damage. The goal is to develop a tool, possibly using artificial intelligence, to better assess donor liver quality and improve transplant safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Hypothermic Oxygenated Machine Perfusion (HOPE/D-HOPE)
- What this could lead to
- If successful, this could lead to a reliable way to assess donor liver quality before transplant, helping doctors decide which organs are safe to use and potentially increasing the number of successful transplants.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly improve outcomes. The findings may not apply to all liver types or transplant centers, and the biomarkers might not predict results accurately enough for clinical use.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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ASST Grande Ospedale Metropolitano Niguarda
Milan, 20162, Italy
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Azienda Ospedaliera San Camillo Forlanini
Roma, 00152, Italy
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IRCCS ISMETT - Istituto Mediterraneo per i Trapianti e le Terapie ad Alta Specializzazione,
Palermo, 90127, Italy
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