Warm liver transplants: could ditching the ice bath reduce organ damage?
NCT ID NCT07692490
First seen Jul 09, 2026 · Last updated Jul 15, 2026 · Updated 3 times
Summary
This study tests a new approach for liver transplantation: after keeping the donor liver warm on a machine, doctors skip the usual cold flush before implanting it. Instead, they use a room-temperature albumin rinse. The goal is to see if avoiding sudden temperature changes reduces early liver injury (called early allograft dysfunction). The trial includes 170 adult liver transplant recipients across multiple centers and follows them for 90 days after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- No recooling procedure (room-temperature albumin flush)
- What this could lead to
- If successful, this simpler approach could reduce early liver damage after transplant, potentially improving patient recovery and graft survival.
- What could go wrong
- This is a relatively small, early-stage trial (170 participants) testing a procedural change. The benefit may be modest or not appear, and there is a risk of unforeseen complications from omitting the standard cold preservation step.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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ASST Papa Giovanni XXIII
NOT_YET_RECRUITINGBergamo, 24127, Italy
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Azienda Ospedale-Università di Padova
NOT_YET_RECRUITINGPadova, 35128, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Azienda Ospedaliera San Camillo Forlanini
NOT_YET_RECRUITINGRoma, 00152, Italy
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Contact
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Azienda Ospedaliera Universitaria Integrata Verona
NOT_YET_RECRUITINGVerona, 37126, Italy
Contact
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Azienda Ospedaliero Universitaria Pisana
NOT_YET_RECRUITINGPisa, 56126, Italy
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Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari - Ospedale Giovanni XXIII
NOT_YET_RECRUITINGBari, 70124, Italy
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Azienda Ospedaliero-Universitaria Policlinico Umberto I - Sapienza Università di Roma
NOT_YET_RECRUITINGRoma, 00161, Italy
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Contact
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Fondazione PTV - Policlinico Tor Vergata
NOT_YET_RECRUITINGRoma, 00133, Italy
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Fondazione Policlinico "Agostino Gemelli" IRCCS
NOT_YET_RECRUITINGRoma, 00168, Italy
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IRCCS Azienda Ospedaliero-Universitaria di Bologna
NOT_YET_RECRUITINGBologna, 40138, Italy
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IRCCS ISMETT - Istituto Mediterraneo per i Trapianti e le Terapie ad Alta Specializzazione
RECRUITINGPalermo, 90127, Italy
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Ospedale Università Policlinico San Martino - IRCCS
NOT_YET_RECRUITINGGenova, 16132, Italy
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Università Politecnica delle Marche, AUO delle Marche
NOT_YET_RECRUITINGAncona, 60126, Italy
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Università di Modena e Reggio Emilia
NOT_YET_RECRUITINGModena, 41124, Italy
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