Liver failure

This study tests a device that keeps donor livers cool and oxygenated before transplant, aiming to reduce early liver problems. About 215 first-time liver transplant patients will receive a liver preserved with this method. The goal is to see if it lowers the risk of early graft …

This trial tests whether a medicine called emapalumab, which calms a specific part of the immune system, can prevent liver failure in children aged 1 year and older with severe hepatitis that hasn't improved with steroids. The study includes a screening group to observe all sever…

This study tests whether adding the drug NTZ to standard care can help people with liver cirrhosis who experience a sudden worsening (acute decompensation) or have developed acute-on-chronic liver failure. The trial enrolls adults with cirrhosis from any cause who have had a rece…

This study looks at whether propranolol, a drug often used for high blood pressure, helps or harms people with advanced cirrhosis (severe liver scarring). The trial will include 466 adults with a MELD score over 9, meaning their liver disease is fairly advanced. Researchers will …

This early-phase trial tests whether a combination of total lymphoid irradiation (a type of radiation) and anti-thymocyte globulin (an antibody drug) can help liver transplant recipients safely stop taking immunosuppressive drugs. The study will enroll 12 adults receiving a liver…

This study compares two methods of preserving livers from deceased donors before transplant: a machine that pumps oxygenated cold fluid through the liver (hypothermic machine perfusion) versus the standard ice-cooled storage. Forty adult liver transplant patients will be randomly…

This study tests a treatment for adults with acute-on-chronic liver failure, a sudden worsening of long-term liver disease. The approach combines blood filtering (hemoadsorption) with half-dose plasma exchange to support the liver until recovery or transplant. About 240 participa…

This study compares a new, personalized way of giving a blood thinner (citrate) during kidney dialysis to the standard method. It involves 142 adults with acute kidney injury or advanced chronic kidney disease who also have liver failure or poor blood flow. The goal is to see if …

This study tests the safety of using a patient's own stem cells (taken from fat) to prevent bile duct complications after a living donor liver transplant. About 20 adults with end-stage liver disease will receive these cells during surgery. The goal is to see if this approach red…

This phase 2 trial tests the cancer pill regorafenib in 20 adults with advanced liver cancer and moderate liver dysfunction (Child-Pugh B) whose disease worsened after first-line immunotherapy. Participants take regorafenib daily for 3 weeks on, 1 week off, until the cancer progr…

This study looks at whether giving vitamin C through a vein can help very sick patients with liver failure and severe infections recover from kidney injury. About 110 patients will get either standard care alone or standard care plus vitamin C. The goal is to see if vitamin C hel…

This study tests a blood purification device called DPMAS for people with acute-on-chronic liver failure (ACLF), a life-threatening condition. About 56 adults will be randomly assigned to standard medical care alone or standard care plus DPMAS. The goal is to see if DPMAS improve…

This study tests whether a telemedicine program using a smartphone app and a smartwatch can help people with advanced liver disease (decompensated cirrhosis) avoid hospital stays and emergency room visits. About 120 adults with this condition will either receive standard care or …

This study compares two intravenous fluids—human albumin and saline—to see which better resolves acute kidney injury in people with decompensated cirrhosis. About 114 adults with moderate to severe kidney damage will receive either treatment. The goal is to improve kidney functio…

This study compares high-volume versus standard plasma exchange in 60 patients with acute liver failure and brain swelling (cerebral edema). The goal is to see if exchanging more plasma (8-9 liters) reduces brain swelling faster and improves survival without a liver transplant. R…

This study tests whether adding a technique called vascular deformation mapping (VDM) to standard CT scans can better predict liver failure after major liver surgery. Researchers will analyze routine preoperative CT images from over 1,000 adults undergoing removal of at least thr…

Acute-on-chronic liver failure (ACLF) is a sudden, life-threatening worsening of long-term liver disease that often leads to multiple organ failure. Standard scoring systems may miss key signs of inflammation and organ damage. This study compares two newer scoring models—the CLIF…

This study investigates how a single dose of the drug ulonivirine is processed by the body in people with mild or moderate liver impairment compared to healthy volunteers. Researchers measure drug levels in the blood over time to see if liver function affects how the drug is brok…

This study investigates how the experimental cancer drug atirmociclib is processed by the body in people with mild, moderate, or severe liver disease compared to those with healthy livers. Participants receive a single oral dose of the drug, and blood samples are taken over time …

This study follows adults waiting for a liver transplant to see how their sleep quality changes from before surgery to six months after. Researchers use questionnaires to measure sleep, anxiety, and other factors. The goal is to understand what influences sleep problems in these …

This study aims to create a score that predicts the risk of infection within 30 days after a liver transplant. Researchers will collect blood samples from 279 liver transplant patients before and after surgery to measure immune markers. The goal is to combine these markers with o…

This study looks at a simple idea: during a liver transplant, the first blood that flows into the new liver may contain harmful substances. By discarding that blood before connecting the liver to the patient's circulation, doctors hope to reduce heart, kidney, and liver problems.…

This large French study will follow 1,810 adults receiving their first liver transplant to see if the way the donor liver is removed affects outcomes. The main focus is on avoiding artery and bile duct complications for three years after transplant. The goal is to identify the be…

This study will follow 400 people with acute liver failure to understand what causes it and what factors affect survival. Researchers will analyze blood and liver tissue samples to find clues. The goal is to create a model that helps doctors decide when a liver transplant is need…

This early-stage study will give a single dose of MDR-001, a GLP-1 receptor agonist tablet, to 32 people: some with mild or moderate liver impairment and some with healthy livers. Researchers want to see how the drug moves through the body and if it is safe in people with liver i…

This study will analyze data from 3,000 living liver donors and their recipients to create a more accurate prediction model for early graft failure after living donor liver transplantation. Researchers will also test how well existing prediction models work. The goal is to give d…

This study looks at how the drug anaprazole sodium is processed by the body and whether it is safe for people with liver or kidney issues, as well as for older adults. About 60 participants will be enrolled to measure drug levels and track any side effects. The goal is to underst…