Can more plasma exchange save lives in acute liver failure?
NCT ID NCT06515145
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study compares high-volume versus standard plasma exchange in 60 patients with acute liver failure and brain swelling (cerebral edema). The goal is to see if exchanging more plasma (8-9 liters) reduces brain swelling faster and improves survival without a liver transplant. Researchers will also monitor side effects like fluid overload and allergic reactions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
plasma exchange (a procedure that filters the blood)
What this could lead to
If it works, this could offer a better way to reduce brain swelling in acute liver failure, potentially improving survival without a transplant.
What could go wrong
This is a small, early-stage trial with only 60 participants. The procedure carries risks like fluid overload, allergic reactions, and lung problems. Success is not guaranteed.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Institute of Liver & Biliary Sciences
New Delhi, National Capital Territory of Delhi, 110070, India