Can more plasma exchange save lives in acute liver failure?

NCT ID NCT06515145

Not yet recruiting Disease control Sponsor: Institute of Liver and Biliary Sciences, India Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study compares high-volume versus standard plasma exchange in 60 patients with acute liver failure and brain swelling (cerebral edema). The goal is to see if exchanging more plasma (8-9 liters) reduces brain swelling faster and improves survival without a liver transplant. Researchers will also monitor side effects like fluid overload and allergic reactions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: plasma exchange (a procedure that filters the blood)
What this could lead to: If it works, this could offer a better way to reduce brain swelling in acute liver failure, potentially improving survival without a transplant.
What could go wrong: This is a small, early-stage trial with only 60 participants. The procedure carries risks like fluid overload, allergic reactions, and lung problems. Success is not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute liver failure brain edema Sepsis Systemic Inflammatory Response Syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LIVER FAILURE CEREBRAL EDEMA

Contacts and locations

Locations

Institute of Liver & Biliary Sciences

New Delhi, National Capital Territory of Delhi, 110070, India

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Other studies related to the condition(s) this trial covers.