Liver failure

This phase 2 trial tests a CMV vaccine (CMV-MVA Triplex) given before a liver transplant to see if it reduces the need for antiviral drugs after surgery. The study enrolls 416 CMV-negative adults awaiting a liver transplant from a CMV-positive donor. Participants receive two vacc…

This trial tests whether adding N-acetylcysteine (NAC) to standard care improves survival in adults with acute liver failure not caused by acetaminophen. Sixty-two patients will be randomly assigned to receive NAC or standard care alone. The study tracks survival at 28 days, hosp…

This study explores whether people with decompensated cirrhosis can receive acute medical care in their own homes instead of a hospital. Participants use remote monitoring devices, lab services, and virtual check-ins from a care team. The goal is to understand patient expectation…

This phase 3 trial tests whether fecal microbiota transplantation (FMT) — capsules containing processed stool from healthy donors — can slow the progression of decompensated cirrhosis, a severe form of liver disease. About 190 adults with advanced cirrhosis will receive either FM…

This phase II trial tests an experimental drug called AS1501 in people with acute-on-chronic liver failure (ACLF), a sudden worsening of liver function in those with chronic liver disease. The study first evaluates safety in a small group, then compares the drug against a placebo…

This study tests a new approach for liver transplantation: after keeping the donor liver warm on a machine, doctors skip the usual cold flush before implanting it. Instead, they use a room-temperature albumin rinse. The goal is to see if avoiding sudden temperature changes reduce…

This trial compares two ways of managing fluids during liver transplant surgery in adults with end-stage liver disease. One strategy limits fluids and uses medications to maintain blood pressure, while the other gives more fluids to optimize heart function. The goal is to see whi…

This trial tests whether using infection surveillance data to guide antibiotic selection can reduce antibiotic resistance in hospitalized cirrhosis patients with bacterial infections. About 198 adults with decompensated cirrhosis and a confirmed or suspected infection will be ran…

This study tests whether giving a higher dose of albumin (a protein) to people with advanced liver cirrhosis and fluid buildup (ascites) can reduce the need for fluid drainage procedures and prevent complications. About 100 adults with hard-to-treat ascites will receive either hi…

This study is testing a telemedicine program called Vet-CALD for Veterans with advanced liver disease. The program pairs patients with a nurse care counselor who helps them understand their illness, set personal health goals, and coordinate care between their regular doctors and …

This study tests whether giving extra albumin (a protein in the blood) after a liver transplant can prevent acute kidney injury. About 400 adult liver transplant recipients will be split into two groups: one gets albumin to keep levels above 30 g/L for five days, the other only g…

This study tests whether a blood-filtering device called DPMAS can help people with acute-on-chronic liver failure, a life-threatening condition. The device removes toxins and inflammatory substances from the blood, which may improve immune function and survival. Forty intensive …

This early-stage trial is testing the drug sacituzumab govitecan in 30 people with advanced solid tumors who also have moderate liver impairment. The main goal is to find a safe starting dose by monitoring side effects and how the drug moves through the body. Participants receive…

This pilot study tests whether giving a combination of two growth factors (G-CSF and darbepoetin) in single or repeated cycles can improve immune function in people with early decompensated cirrhosis. Sixty participants will be randomly assigned to receive either the growth facto…

This study tests whether a home monitoring system called CirrhoCare can help people with decompensated cirrhosis avoid unplanned hospital visits. Participants use an Apple Watch, iPhone app, and Bluetooth devices to track their health at home. The trial will compare this approach…

This study looks at whether eating protein evenly throughout the day, combined with a regular exercise program, can improve nutrition, muscle mass, and strength in people with end-stage liver disease awaiting a transplant. 90 participants will be split into three groups: one with…

This early-phase trial is testing a new bioartificial liver device that uses liver cells grown from stem cells. It will be given to 12 people with liver failure or small-for-size syndrome. The main goal is to see if the treatment is safe and tolerable, while also checking for any…

This early study tests whether using mesenchymal stem cells in a blood purification device is safe and can help adults with liver failure. Ten participants will receive the treatment alongside standard care. Researchers will track survival at 28 days and check for side effects. T…

This study tests whether text message reminders and a smart pillbox can help teenagers and young adults take their daily anti-rejection medicine on time after a kidney or liver transplant. About 65 participants aged 13-25 will use an electronic pillbox that tracks when they take …

This study tests whether a donor stem cell infusion can retrain the immune system to accept a liver transplant without lifelong anti-rejection drugs. Twelve adults who had a liver transplant from a matched living donor at least one year ago will receive the infusion after a mild …

This study compares a new method using ROTEM (a rapid blood clotting test) to standard care for deciding whether to give blood products before high-risk procedures in patients with decompensated liver cirrhosis. The goal is to see if the ROTEM-guided approach reduces the number o…

This pilot study tests whether adding the statin atorvastatin to a standard beta blocker can help people with decompensated cirrhosis, a severe form of liver disease. Fifty participants will receive either atorvastatin plus their usual beta blocker or a placebo plus beta blocker,…

This study tests whether empagliflozin, a diabetes drug, can help people with cirrhosis and ascites (fluid buildup in the belly) get rid of excess salt and water. About 20 adults on stable diuretics will take the drug or a placebo for 14 days. Researchers will measure changes in …

This phase 3 trial tests whether giving low-dose arginine vasopressin during liver transplant surgery can prevent acute kidney injury, a common complication. Researchers will compare vasopressin to the standard drug norepinephrine in 304 adults. The goal is to see if vasopressin …

This study tests whether a biomarker can predict which people with advanced liver cirrhosis and fluid buildup (ascites) will benefit from regular albumin infusions. About 240 adults will receive either albumin or a placebo every 10 days for 6 months. The goal is to see if the bio…

This study tests a new treatment called RTX001 for people with severe liver scarring (cirrhosis) that has led to complications. RTX001 uses the patient's own immune cells, modified in a lab to reduce inflammation and scarring. The trial will enroll 30 adults to check if the thera…

This study tests a combined blood-filtering system (DPMAS and plasma exchange) in 25 adults with acute-on-chronic liver failure who are either waiting for a liver transplant or not eligible for one. The goal is to see if this artificial liver support can keep patients alive witho…

This study tests whether a standard volume of plasma exchange (blood filtering) works as well as a high volume in children aged 3 to 18 with acute liver failure. The goal is to see which approach helps more children survive without needing a liver transplant by day 21. Forty part…

This study tests if transplanting a piece of abdominal wall (the muscle and tissue covering the belly) can safely repair large defects, like hernias or injuries. It can be done alone or with another organ transplant, like a kidney or liver. Only 5 adults aged 18-65 are being enro…

This study follows 30 adults with end-stage liver cirrhosis who receive a living-donor liver transplant. Researchers track bleeding and clotting complications to identify risk factors and improve prevention strategies. The goal is to make liver transplants safer in the early reco…

This study tests if a drug called darbepoetin can lower the need for blood transfusions during liver transplant surgery. About 140 adults on the liver transplant waiting list with low hemoglobin will receive either the drug or a placebo. The goal is to see if the drug safely redu…

This study tests whether a steroid drug (methylprednisolone) can help people with severe liver injury caused by medications. The trial includes 232 adults with high bilirubin levels. Participants receive either steroids plus standard care or standard care alone, and doctors track…

This study tests whether a medicine called tranexamic acid can reduce blood loss during adult liver transplant surgery. About 1,546 people will be randomly assigned to receive either the drug or a placebo. The main goal is to see if the drug works better than placebo at controlli…

This study looks at whether a procedure called TIPS, which creates a bypass in the liver, can help people with advanced cirrhosis achieve 'recompensation' — meaning the liver partially recovers and complications ease. Researchers will follow 250 patients for one year after TIPS t…

This early study tests whether siplizumab, given at the time of liver transplant, can safely prevent the immune system from attacking the new liver. Up to 8 adults with autoimmune hepatitis or primary sclerosing cholangitis will receive two doses. The main goal is to check for se…

This Phase 2 trial is testing an experimental drug called F573 in 97 people with acute liver failure or acute-on-chronic liver failure. Participants receive daily injections of F573 or a placebo for 7 days. The main goal is to check safety and side effects, while also looking at …

This study tests whether the diabetes drug empagliflozin (Jardiance) can safely raise low sodium levels in people with certain conditions like SIADH, liver failure, or kidney failure. About 172 adults with chronic low sodium will receive either the drug or a placebo for up to 30 …

This trial tests whether a machine called Normothermic Machine Perfusion (NMP) can revive moderately fatty donor livers so they can be safely transplanted. Researchers will place livers with 30-60% fat on the machine, check their quality, and transplant those that meet safety cri…

This early-stage trial is testing whether giving a mix of healthy gut bacteria (from donors) to people hospitalized with serious liver disease is safe and tolerable. The study involves 24 adults with liver failure or cirrhosis who have low levels of certain gut metabolites. Resea…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during liver transplant surgery. The device measures blood clotting in real time. Researchers hope it will reduce bleeding and the amount of blood products needed. The…

This phase 3 trial tests a new solution called Custodiol-N for preserving donated kidneys, livers, and pancreases before transplant. About 362 recipients will be randomly assigned to receive organs stored in either Custodiol-N or the standard Custodiol solution. The goal is to se…

This study is testing whether measuring spleen stiffness with a non-invasive scan can accurately diagnose and monitor portal hypertension in people with advanced chronic liver disease. Researchers will enroll 200 participants and track them over time to see if this simple test ca…

This pilot study tests a new cognitive test using building blocks to quickly screen for minimal hepatic encephalopathy (MHE), a subtle brain complication in people with liver disease. Researchers will compare the test's accuracy against standard methods in 100 adults with liver f…

This study is testing whether a special MRI scan called 3D-MRE can accurately detect high blood pressure in the liver (portal hypertension) caused by cirrhosis or advanced liver disease. Currently, doctors use an invasive catheter procedure (HVPG) to measure this pressure. The st…

This study tests if drinking a carbohydrate beverage before liver transplant surgery helps patients recover more quickly and spend fewer days in the hospital. About 434 adults receiving a liver transplant will be randomly assigned to drink either the carbohydrate drink or a place…

This study explores whether a new MRI-based muscle assessment score (MAsS) can predict adverse outcomes in people with end-stage liver disease who are candidates for a liver transplant. Researchers will measure muscle fat and volume from standard MRI scans and track hospital stay…

This study is looking at whether detailed heart imaging can help predict heart problems in people with liver cirrhosis who undergo a procedure called TIPSS, which creates a shunt to relieve pressure in the liver. Participants will have heart MRIs and echocardiograms before, short…

This study is collecting information from 10,000 liver transplant patients across Europe to create a new, up-to-date reference for what good outcomes look like when using machine perfusion (a technique that keeps donated livers healthier before transplant). The goal is to help do…

This study tests whether artificial intelligence can more accurately predict which patients on the liver transplant waiting list are at highest risk of dying or becoming too sick for surgery. Researchers will follow 630 adults with severe liver disease or liver cancer across five…

This European study is collecting health data from 4,500 adults listed for liver transplantation across 50 centers. The goal is to design and test new AI-based models that predict which patients are most likely to die or become too sick for transplant while waiting. If accurate, …

This study looks at a heart condition called cirrhotic cardiomyopathy that can affect people with advanced liver disease (cirrhosis). Researchers want to learn how common it is, what increases the risk, and whether bile acids in the blood play a role. About 440 adults with decomp…

This study follows 5000 adults with advanced liver disease to see how frailty — measured by grip strength, chair stands, and balance — relates to their outcomes before and after a liver transplant. Participants are tested at every clinic visit and for a year after transplant, the…

This study investigates whether measuring the thickness of the carotid artery (a major artery in the neck) before surgery can help predict blood pressure swings and complications during liver transplant operations. Researchers will measure carotid artery thickness using a simple,…

This early-stage study looks at how a new drug, INCB123667, behaves in the bodies of 16 adults with moderate or severe liver disease. Researchers will measure drug levels and watch for side effects. The goal is to gather safety information, not to treat the liver condition.

This early-stage study is testing a single dose of the drug eloralintide in 36 people with different levels of liver function—from healthy to severely impaired. Researchers want to see how the body absorbs and processes the drug and whether it causes side effects. The goal is to …

This study looks at whether measuring a substance called FMN in the fluid used to preserve donated livers can predict how well the liver will work after transplant. Researchers will collect samples from 850 liver transplant patients at multiple hospitals. The goal is to see if FM…

This study looks at how inflammation and liver repair differ in people with alcoholic hepatitis versus those with alcoholic cirrhosis or healthy livers. Researchers will collect blood, liver tissue, and fluid samples from 450 participants. The goal is to better understand what dr…

This study follows 60 adults with cirrhosis who are waiting for a liver transplant but do not have diabetes. Researchers want to see if tests like glucose monitoring, oral glucose tolerance tests, and wrist activity trackers can predict who will develop diabetes after the transpl…

This study follows 275 infants who received a liver transplant to see how they grow over time. Researchers want to understand growth patterns and find ways to improve care. The study is observational, meaning no new treatment is being tested.

This study from Mayo Clinic aims to understand the individual and social reasons why some patients with end-stage liver disease are not listed for or do not receive a liver transplant. Researchers will track 100 patients to see who gets on the waiting list, who receives a transpl…

This study looks at whether the amount of healthy liver removed during surgery can predict liver failure afterward. Researchers will create a risk model based on 1,600 patients who had liver surgery for cancer. The goal is to help doctors identify high-risk patients before surger…

This study tracks 15 people getting a simultaneous liver-kidney transplant to see how much their own kidneys recover. Researchers use a special nuclear scan and blood tests to measure kidney function before and after transplant. The goal is to create a way to predict who might no…

This study looks at how frailty, muscle loss, nutrition, and mental health affect people waiting for a liver transplant. Researchers will test physical strength, walking ability, and daily living skills, and also check nutrition and psychological well-being. The goal is to see wh…

This study looks at how well people who have had a liver transplant can move and function. Researchers will use a 30-second test where patients lie down and sit up as many times as they can. The goal is to see how this test relates to muscle strength, exercise ability, and overal…

This study looks at whether a tool called the HScore can accurately diagnose hemophagocytic lymphohistiocytosis (HLH) in intensive care patients with liver failure or cirrhosis. Researchers will review medical records of 100 adults admitted to one hospital over ten years who had …

This study is testing two scoring methods (PLEASE and M10S20) to see if they can better predict serious liver events, liver cancer, and death in 600 people with advanced chronic liver disease. Participants are randomly assigned to standard care or a risk-based monitoring schedule…

This study looks at how a drug called LY3537031 moves through the body in people with mild, moderate, or severe liver problems compared to healthy volunteers. About 32 adults will receive a single injection under the skin. The goal is to understand how liver function affects drug…

This study tests a web-based app that helps people waiting for a kidney or liver transplant share their story on social media to find a living donor. Researchers want to see if this approach brings in more potential donors and leads to more transplants. The study involves 1000 ad…

This study tests a special follow-up program called the Transitional Liver Clinic (TLC) for people with advanced liver disease after they leave the hospital. The program includes extra phone calls or video visits and more attention from liver specialists. The goal is to see if th…

This study follows 10,000 people with advanced chronic liver disease at Vienna General Hospital. Researchers will track their health over time, collect blood, urine, and tissue samples, and record complications like bleeding or liver failure. The goal is to better understand how …

This registry follows 250 patients with decompensated liver cirrhosis who receive a TIPS procedure, a shunt placed in the liver to reduce pressure. Researchers will track survival, brain function, nutrition, and quality of life over one year. The goal is to identify which patient…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …