Can personalized antibiotics outsmart resistant bacteria in liver transplants?
NCT ID NCT07759453
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial tests whether giving liver transplant patients antibiotics tailored to the specific resistant bacteria they carry (CPE) can prevent infections better than standard antibiotics. It involves adults colonized with CPE who are undergoing a liver transplant. Researchers will compare the two approaches to see which reduces early infections and how they affect gut bacteria.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Targeted antibiotic prophylaxis using ceftazidime-avibactam or meropenem-vaborbactam, chosen based on the specific resistant bacteria each patient carries
- What this could lead to
- If effective, this approach could reduce dangerous infections after liver transplant in patients carrying resistant bacteria, potentially improving survival and recovery.
- What could go wrong
- The trial is relatively small and early, and results may not apply to all patients. There are also risks of antibiotic side effects and disruption of gut bacteria.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino
Torino, TO, 10126, Italy
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Azienda Ospedaliero Universitaria Pisana
Pisa, PI, 56126, Italy
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Irccs Azienda Ospedaliero-Universitaria Di Bologna
Bologna, BO, 40138, Italy
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