Could one antibiotic dose before tooth pulling prevent infections in Immune-Weakened patients?

NCT ID NCT07275580

Not yet recruiting Prevention Sponsor: University of Sao Paulo General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This study tests whether a single dose of amoxicillin before a simple tooth extraction can prevent infections in people with autoimmune rheumatic diseases who are on immune-suppressing medications. Researchers will compare infection rates between those who get the antibiotic and those who get a placebo. The goal is to see if this common practice is actually effective and safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Amoxicillin
What this could lead to: If successful, this could show that a single antibiotic dose is enough to prevent infections after tooth extraction in immunosuppressed patients, reducing unnecessary antibiotic use.
What could go wrong: This is a Phase 4 trial, but it is not yet recruiting and has a moderate size (352 participants). The results may not apply to all autoimmune diseases or extraction types, and the placebo group could show similar infection rates.

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Conditions

The condition(s) this trial relates to.

autoimmune disease rheumatic disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIBIOTIC PROPHYLAXIS AUTOIMMUNE RHEUMATIC DISEASES INFECTION PREVENTION TOOTH EXTRACTION

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