Could a dab of antibiotic in the tooth socket dull post-extraction pain?

NCT ID NCT07738861

Completed Symptom relief Sponsor: CMH Lahore Medical College and Institute of Dentistry Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial tests whether placing tetracycline directly into the tooth socket after removing a lower molar can reduce post-operative pain. About 74 adults needing a molar extraction will be randomly assigned to receive either the antibiotic or no extra treatment. Pain levels will be measured at 24 hours, 48 hours, and 7 days after surgery, along with how many painkillers each person needs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tetracycline (250 mg) mixed with sterile saline, placed directly into the extraction socket after mandibular molar removal
What this could lead to: If effective, this simple, low-cost approach could become a standard way to ease pain and speed recovery after molar extractions.
What could go wrong: This is a small, early-stage trial, and the benefit may be modest. Tetracycline is an antibiotic, so there is a small risk of allergic reaction or local irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MANDIBULAR MOLAR EXTRACTION POSTOPERATIVE PAIN TOOTH EXTRACTION

Contacts and locations

Locations

CMH Lahore

Lahore, Pakistan

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