MENOPAUSE

This study investigates whether eating two servings of Greek yogurt daily—either whole milk or skimmed—can improve muscle protein synthesis, blood sugar control, and thinking skills in post-menopausal women who are overweight or have obesity. Participants will follow a standardiz…

This trial explores whether starting transdermal estradiol (a skin gel or patch) soon after menopause can protect the heart and brain in women who have hot flashes and at least one cardiovascular risk factor. One hundred women will be randomly assigned to receive the hormone ther…

This study tests whether a personalized digital health program — using a smartphone app, wearable devices, and lifestyle coaching — can help midlife women with abdominal obesity improve their diet, physical activity, sleep, and menopausal symptoms. Participants will wear a smartw…

This study tests whether a daily prebiotic drink (containing inulin) can improve blood sugar control in 30 postmenopausal women with prediabetes. Participants will consume the drink or a placebo for 4 weeks. The goal is to see if this simple dietary supplement can help reduce the…

This study looks at whether estradiol patches can improve shoulder healing after rotator cuff repair in post-menopausal women. About 58 women will receive either an estradiol patch or a placebo patch for three months after surgery. The goal is to see if the hormone helps reduce p…

This study tests whether a daily fermented soy product, Haelan 951, can help ease hot flashes and improve sleep in women going through menopause. About 25 peri- and postmenopausal women aged 45-65 will take the product for 45 days and track their symptoms. The goal is to see if t…

This trial tests whether a six-week relaxation training program, delivered by a physiotherapist via video call, can help postmenopausal women with symptoms like hot flashes, poor sleep, and fatigue. Thirty women in early menopause will be randomly assigned to either the relaxatio…

This study will test whether a 12-week online fascial yoga program can lower stress and improve cognitive control and flexibility in menopausal women. One hundred women aged 45-65 will be randomly assigned to either the yoga program or usual care. The yoga includes gentle myofasc…

This study tests whether a program called Waning Moon is practical and well-liked by urban American Indian and Alaska Native women going through menopause. The program includes four weekly group sessions led by community health workers, covering menopause education, mindfulness, …

This study tests whether a daily capsule containing lotus seed and rice germ extract, called ZenRest™, can improve sleep quality in menopausal women aged 40 to 65 who have mild-to-moderate sleep problems. Participants take either the supplement or a placebo for six weeks, and sle…

This pilot study tests a web-based program called Cuidar-ME, designed to help women going through perimenopause or menopause feel better mentally and emotionally. The program includes 8 weekly online modules based on cognitive-behavioral therapy. Researchers will recruit 150 wome…

This study looks at whether coloring mandalas can help women going through menopause feel less stressed, have a better outlook on menopause, and be more mindful. About 140 women aged 45 to 55 will be randomly assigned to color mandalas or not. The goal is to see if this simple, r…

This study looks at whether monthly group medical visits focused on lifestyle medicine and mindfulness can help women ages 40-60 going through perimenopause or menopause. Over eight months, participants will learn about healthy living, practice mindfulness, and have check-ups to …

This study tests a 4-week education and counseling program for women aged 45-55 going through natural menopause. The program covers menopause changes, coping skills, and support. Researchers will measure if it reduces symptoms, depression, and improves quality of life compared to…

This study compares two vaginal treatments—estrogen and DHEA—for relieving menopause symptoms like vaginal dryness, discomfort, and painful intercourse. About 324 women aged 40-90 will use one of the treatments and report changes in symptoms and sexual health. The goal is to help…

This study tests whether weekly virtual reality sessions can help manage menopause symptoms like hot flashes and night sweats. Women aged 45 to 60 who have at least 28 hot flashes per week will use a VR headset at home for 8 weeks. Researchers will track changes in hot flash freq…

This study tests whether four weekly motivational interviewing sessions can reduce menopause myths and help women grow from the experience. 96 postmenopausal women will be randomly assigned to either the talking therapy or usual care. Researchers will measure changes in beliefs a…

This study tests whether a daily lutein supplement made from microalgae can slow cognitive decline in postmenopausal women with obesity. 300 women aged 48-60 will take either 6 mg, 14 mg, or a placebo for 180 days. Researchers will measure changes in memory, attention, and inflam…

This study tests whether clinical hypnosis and self-hypnosis can reduce hot flashes and improve quality of life in menopausal women who cannot or choose not to take hormone therapy. About 94 women will be split into two groups: one receiving hypnosis sessions and the other receiv…

This study tests whether a 12-week foot and ankle strengthening program can improve physical function and quality of life in menopausal women aged 45 to 65. About 70 women will be randomly assigned to either the exercise program or their usual activities. The program includes one…

This study looks at whether laughter yoga can help menopausal women feel better. Researchers will split 80 women into two groups: one does laughter yoga for 8 sessions, the other does nothing new. They will check if the yoga group has fewer menopause symptoms, better sleep, and a…

This study tests a daily testosterone gel to see if it can safely improve sexual interest and arousal in women going through menopause. Researchers will compare the gel to a placebo in 150 women aged 40-65 who have been diagnosed with low sexual desire. The goal is to provide a m…

This study tests whether an 8-week Mindfulness-Based Stress Reduction (MBSR) program can reduce hot flashes and improve sleep in menopausal women. 90 women aged 45-60 with hot flashes and poor sleep will be randomly assigned to either the MBSR program or no intervention. The prog…

This study tests if a gentle, noninvasive brain stimulation technique called transcranial electrical stimulation (TES) can help ease menopause symptoms like hot flashes, depression, anxiety, memory problems, and muscle pain. Researchers will enroll 50 women aged 40-60 who are in …

This study will test a version of cognitive behavioral therapy (CBT) specially designed for women veterans aged 45 and older who are dealing with menopause symptoms. The therapy teaches practical coping strategies for hot flashes, mood changes, and sleep problems. Researchers wil…

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This early study tests whether a drug called gemtesa (used for overactive bladder) can improve blood vessel function in women aged 18 to 70. Researchers want to see if targeting beta3 receptors in blood vessels can help them relax and improve blood flow. The trial involves 60 hea…

This study examines how bladder, bowel, and sexual symptoms change across different stages of menopause in women aged 40 to 65. Researchers will compare symptoms in perimenopausal, early postmenopausal, and late postmenopausal women using validated questionnaires. The goal is to …

This study looks at how menopause and poor sleep change heart structure and function in women aged 48-58 with type 2 diabetes. Researchers will use heart ultrasounds to measure early signs of heart strain. No treatment is given; the goal is to better understand these risks.

This study looks at how two types of non-invasive brain stimulation affect brain activity, and whether using them together works better than alone. The goal is to understand why brain stimulation for depression is less effective in women after menopause, possibly due to lower est…

This study looks at whether specially trained pharmacists in Nova Scotia can safely prescribe hormone therapy and other treatments for menopause symptoms. About 200 people assigned female at birth will receive care from pharmacists at appointment-based pharmacies. The goal is to …

This study is a registry that will collect health information from up to 5,000 women experiencing perimenopause, menopause, or premature ovarian insufficiency. Researchers will gather data from medical records and ongoing visits to a specialized clinic, tracking symptoms, treatme…

This study aims to learn more about the menopause journey by collecting data from wearable devices and a smartphone app. Researchers will track symptoms and daily experiences in 1,250 women aged 35-55 to help both individuals and doctors better understand perimenopause and menopa…

This study looks at how menopausal hormone therapy (MHT) affects the heart's ability to pump blood. Researchers will compare heart function in postmenopausal women who use MHT and those who don't. The goal is to understand the role of the nervous system in these changes. About 50…

This study will hold focus groups with 24 women aged 45-60 who are part of a multidisciplinary menopause program at Paris Saint-Joseph Hospital. The goal is to understand their personal experiences and perceptions of menopause, including physical symptoms, emotional changes, and …

This study follows 2100 women under 55 who had a hysterectomy, some with fallopian tube removal and some without. Researchers want to see if removing the tubes leads to earlier menopause. Participants will collect a few drops of blood at home and answer online questionnaires twic…

This study looks at ways to help VA medical centers put proven health programs into practice for women Veterans in midlife. The programs focus on heart health, weight management, diabetes, mental health, and menopause care. Researchers will test two support strategies at 18 VA si…

This study looks at how menopause changes the way the body processes escitalopram, a common antidepressant. Researchers will measure drug levels in the blood of 94 women aged 40-60 who are premenopausal or menopausal and taking the medication for depression or anxiety. The goal i…