Sleep showdown: HRT vs. CBT for menopausal insomnia
NCT ID NCT06497894
First seen Jan 18, 2026 · Last updated Jun 19, 2026 · Updated 24 times
Summary
This study tests whether hormone replacement therapy (HRT) or cognitive behavioral therapy (CBT-I) can help perimenopausal women sleep better. Fifty-four women with insomnia and hot flashes will receive either HRT, weekly CBT-I sessions, or sleep hygiene tips for 8 weeks. Researchers will track sleep quality using diaries and brain-wave monitors to see which approach works best.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University Hospital of Bern, Department of Gynecological Endocrinology & Reproductive Medicine
RECRUITINGBern, 3010, Switzerland
Contact Phone: •••-•••-••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Hormone Replacement Therapy (HRT) and Cognitive Behavioral Therapy for Insomnia (CBT-I)
What this could lead to
If successful, this could show that CBT-I is a safe, non-drug option for treating insomnia in menopausal women, or confirm HRT's effectiveness for sleep.
What could go wrong
This is a small Phase 4 trial with only 54 participants, so results may not apply to everyone. Both treatments have limitations and may not work for all women.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.