Could estrogen ease Menopause-Linked depression and psychosis?
NCT ID NCT05282277
First seen May 02, 2026 · Last updated May 02, 2026
Summary
This study looks at whether giving estradiol (a form of estrogen) can help perimenopausal women who started having depression, psychosis, or loss of pleasure during this life stage. About 100 women aged 44-55 will receive either estradiol or a placebo, and researchers will use brain scans to see how the treatment affects brain activity related to rewards. The goal is to understand if estradiol can ease these symptoms and improve quality of life.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of North Carolina at Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27514, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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