Freezing balloon zaps precancerous cells when heat fails

NCT ID NCT03554356

First seen Dec 11, 2025 · Last updated May 02, 2026 · Updated 18 times

Summary

This study tests a freezing balloon device to remove abnormal cells in the esophagus of people with Barrett's esophagus that did not improve after standard heat treatments. About 70 adults with precancerous changes will receive the freezing treatment and be followed for 12 months. The goal is to see if the procedure can safely clear all abnormal tissue and prevent progression to cancer.

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Contacts and locations

Locations

  • Columbia University

    New York, New York, 10032, United States

  • Geisinger Clinic

    Danville, Pennsylvania, 17822, United States

  • Georgetown University

    Washington D.C., District of Columbia, 20057, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21205, United States

  • Mayo Clinic Rochester

    Rochester, Minnesota, 55905, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Northwell Health

    Lake Success, New York, 11042, United States

  • UNC Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

  • UTHealth Science Center/Herman Memorial

    Houston, Texas, 77030, United States

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294, United States

Conditions

Explore the condition pages connected to this study.