Freezing therapy offers new hope for tough Barrett's cases

NCT ID NCT03554356

Ongoing Disease control Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study tests a freezing device (CryoBalloon) to treat Barrett's esophagus that hasn't improved after multiple standard heat treatments. About 70 adults with precancerous changes in the esophagus will receive the freezing therapy. The goal is to safely remove all abnormal tissue and prevent cancer progression.

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Conditions

The condition(s) this trial relates to.

Barrett esophagus esophagus carcinoma in situ gastric intestinal metaplasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BARRETT ESOPHAGUS ESOPHAGEAL DYSPLASIA INTESTINAL METAPLASIA

Contacts and locations

Locations

Columbia University

New York, New York, 10032, United States
Geisinger Clinic

Danville, Pennsylvania, 17822, United States
Georgetown University

Washington D.C., District of Columbia, 20057, United States
Johns Hopkins University

Baltimore, Maryland, 21205, United States
Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Northwell Health

Lake Success, New York, 11042, United States
UNC Chapel Hill

Chapel Hill, North Carolina, 27599, United States
UTHealth Science Center/Herman Memorial

Houston, Texas, 77030, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States

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