BARRETT ESOPHAGUS

This study tests a new device called EndoRotor, which mechanically removes the damaged lining of the esophagus, against the standard heat-based radiofrequency treatment for people with Barrett's esophagus who have precancerous cells (dysplasia). The goal is to see if the new meth…

This phase 2 trial tests whether obeticholic acid can reduce damage from bile acids in people with Barrett's esophagus, a condition that can lead to esophageal cancer. About 30 adults with Barrett's esophagus will take the drug or a placebo for 6 months. Researchers will measure …

This study compares two standard approaches for Barrett's esophagus with low-grade dysplasia: regular monitoring with biopsies (surveillance) versus a procedure to remove or burn away precancerous cells (endoscopic eradication therapy). Researchers want to find out which method i…

This trial compares two ways to sample tissue in people with Barrett's esophagus, a condition that raises the risk of esophageal cancer. The standard method takes four small tissue samples every 2 centimeters, while the newer method uses a brush to collect cells over a wider area…

This trial is testing a new, less invasive way to detect Barrett's esophagus, a condition that can lead to esophageal cancer. Participants swallow a capsule attached to a string that expands into a sponge in the stomach, collecting cells as it is pulled back up. The goal is to se…

This study looks at whether taking multiple saliva samples over time can better detect Barrett's esophagus, a condition where the lining of the food pipe changes and can raise the risk of cancer. About 275 adults who have had or will have an endoscopy will provide saliva samples.…

This study tests a simple, non-invasive device called EndoSign, which is a sponge on a string that you swallow in a capsule. The sponge collects cells from the esophagus, which are then tested for signs of Barrett's esophagus, a condition that can lead to cancer. The results will…

This study aims to see if certain chemicals (oncometabolites) in a person's breath and blood can spot early-stage gastro-esophageal cancer. Researchers will compare samples from 1,000 people, including those with cancer, those with Barrett's esophagus (a precancerous condition), …

This study is testing a new, less invasive way to diagnose Barrett's esophagus and esophageal cancer using a sponge capsule that patients swallow. The sponge collects cells from the esophagus, which are then analyzed for signs of disease. Researchers will enroll 1,550 people aged…

This study is testing a simple, less invasive way to detect early signs of Barrett's esophagus, esophageal cancer, and stomach cancer. Participants swallow a capsule attached to a string, which expands into a sponge in the stomach to collect cell samples. Researchers then look fo…

This study aims to see if a new office-based test (EsoCheck balloon and EsoGuard lab test) can accurately detect Barrett's esophagus in people who do not have chronic heartburn. Barrett's esophagus is a condition that can lead to esophageal cancer, but it is often missed in peopl…

This study is creating a large database of information from 10,000 people with esophagus problems like GERD, achalasia, and other motility disorders. Researchers will collect data from standard tests to better understand these conditions. The goal is to improve diagnosis and trea…

This study looks at how the esophagus changes in people with a precancerous condition called Barrett's esophagus who are getting a treatment called radiofrequency ablation (RFA). Researchers will use two special devices during routine endoscopies to measure the tightness and heal…

This study is creating a large database to compare two ways of taking tissue samples from the esophagus: standard forceps biopsies and a brush-based method called WATS3D. Researchers want to see if the brush method helps doctors find Barrett's esophagus or early warning signs of …

This registry study is tracking 1,000 adults who are scheduled to undergo endoscopic submucosal dissection (ESD), a procedure that removes deep tumors from the digestive tract without major surgery. Researchers want to see how well ESD works in a Western population, measuring thi…

This pilot study aims to see how common Barrett's esophagus is in people with eating disorders who have been purging (vomiting or ruminating) for at least 5 years. Researchers will use a simple, non-endoscopic device called EsoGuard to collect cell samples from the esophagus. The…

This pilot study tests a new swallowable capsule that uses optical coherence tomography (OCT) to take detailed images of the esophagus and collect targeted tissue samples from areas of concern in people with Barrett's esophagus. The goal is to see if this less invasive method can…

This study follows over 3,000 people with low-risk Barrett's esophagus who have stopped having routine endoscopic surveillance, as recommended by new guidelines. Researchers will track them for at least 10 years to see if stopping these scopes leads to a rise in serious esophagea…