BARRETT ESOPHAGUS

This study looks at whether taking multiple saliva samples over time can better detect Barrett's esophagus, a condition where the lining of the food pipe changes and can raise the risk of cancer. Researchers will collect saliva from 275 adults who have had or will have an endosco…

This study is testing a simple, non-invasive device called EsophaCap — a sponge in a capsule that you swallow. It collects cells from the food pipe and stomach to look for DNA changes that might signal early cancer or pre-cancer conditions like Barrett's esophagus. The goal is to…

This study tests a new, office-based method to detect Barrett's esophagus—a condition that can lead to esophageal cancer—in people who do not have chronic heartburn. Participants will answer a questionnaire, swallow a capsule balloon test (EsoCheck), and have a lab analysis (EsoG…

This study tests a pill-sized sponge on a string that people swallow to collect cells from the esophagus. The sample is then checked for signs of Barrett's esophagus, a condition that can lead to cancer. The goal is to see if this simple, low-cost method works as well as a standa…

This study is testing a new, less invasive way to diagnose Barrett's esophagus and early esophageal cancer using a sponge capsule device. Participants swallow the capsule, which collects cells from the esophagus for analysis. The goal is to see if this method is accurate and safe…

This study tests a new way to detect Barrett's esophagus, a condition that can lead to cancer, without using a traditional endoscopy. Participants swallow a capsule with a sponge that collects cells from the esophagus. The cells are then tested for specific markers and compared t…

This study is testing whether certain chemicals in a person's breath and blood can help detect early-stage gastro-esophageal cancer. Researchers will compare samples from 1000 people, including those with cancer, those with a pre-cancer condition called Barrett's esophagus, and h…

This study tests whether obeticholic acid can prevent esophageal cancer in 30 adults with Barrett's esophagus, a condition that raises cancer risk. The drug works by reducing harmful bile acids that damage the esophagus. Participants take the drug or a placebo for a set time, and…

This study follows over 3,000 people in the Netherlands with low-risk Barrett's esophagus who have stopped having regular endoscopies. The goal is to see if stopping surveillance leads to more cases of advanced esophageal cancer over 10 years. Participants only give permission to…

This study collects data from 90,000 adults to compare two ways of taking tissue samples from the esophagus: standard forceps biopsies and a brush method called WATS3D. The goal is to see which method better detects Barrett's esophagus and early abnormal cell changes. Participant…

This study looks at the best way to manage Barrett's esophagus with low-grade dysplasia, a condition where the esophagus lining has abnormal but not yet cancerous cells. Researchers will compare two common approaches: regular check-ups with biopsies (surveillance) versus a proced…

This study is observing how well a procedure called endoscopic submucosal dissection (ESD) works for removing abnormal growths in the esophagus and digestive tract. It will include 1,000 adults who are already scheduled for this procedure as part of their standard care. The goal …

This study tests a new swallowable capsule that takes detailed images of the esophagus and collects tiny tissue samples from suspicious areas. The goal is to see if this method can safely and effectively gather tissue for genetic analysis, potentially improving early detection of…

This study watches how the esophagus changes in people getting radiofrequency ablation for Barrett's esophagus, a condition that can lead to cancer. Ten adults will have extra measurements taken during their routine endoscopies. The goal is to gather information that could help p…

This study aims to find out how common Barrett's esophagus is in people with eating disorders who frequently purge (vomit) or ruminate. Researchers will use a simple, non-invasive test on 25 adults admitted to a specialized eating disorder treatment center. The goal is to better …