BARRETT ESOPHAGUS

This study tests a new way to detect Barrett's esophagus, a condition that can lead to cancer, without using a traditional endoscopy. Participants swallow a capsule with a sponge that collects cells from the esophagus. The cells are then tested for specific markers and compared t…

This study is testing a sponge capsule device that people swallow to collect cells from the esophagus. The goal is to see if it can accurately detect Barrett's esophagus and early signs of esophageal cancer in adults aged 50-85 with risk factors like chronic acid reflux. If succe…

This study tests a new, less invasive way to screen for Barrett's esophagus, a condition that can lead to esophageal cancer. Instead of a traditional endoscopy, participants swallow a small sponge on a string (Cytosponge) to collect cell samples from the esophagus. The goal is to…

This study aims to see if certain chemicals in a person's breath and blood can help detect early-stage gastro-esophageal cancer. Researchers will compare samples from people with cancer, those with Barrett's esophagus (a pre-cancer condition), and healthy volunteers. Participants…

This study aims to see if a simple capsule balloon test (EsoCheck) followed by a lab test (EsoGuard) can accurately detect Barrett's esophagus—a condition that can lead to esophageal cancer—in people who do not have chronic heartburn. About 800 adults scheduled for a routine colo…

This study is testing a simple, non-invasive device called EsophaCap — a sponge in a capsule that you swallow. It collects cells from the food pipe and stomach to look for DNA changes that might signal early cancer or pre-cancer conditions like Barrett's esophagus. The goal is to…

This study tests whether obeticholic acid can prevent esophageal cancer in 30 adults with Barrett's esophagus, a condition that raises cancer risk. The drug works by reducing harmful bile acids that damage the esophagus. Participants take the drug or a placebo for a set time, and…

This study looks at whether taking multiple saliva samples over time can better detect Barrett's esophagus, a condition that raises the risk of esophageal cancer. Researchers will collect saliva from 275 adults who have had or are scheduled for an upper endoscopy. The goal is to …

This study looks for Barrett's esophagus, a condition that can lead to cancer, in 25 adults with eating disorders who have been purging (vomiting or ruminating) for at least 5 years. Researchers will use a simple, non-endoscopic test to check for it. The goal is to see if current…

This study is tracking 1,000 adults who are already scheduled to have a procedure called endoscopic submucosal dissection (ESD) to remove abnormal growths in the esophagus or stomach. Researchers want to see how often the growth is removed in one piece and with clean edges. No ne…

This study follows over 3,000 people in the Netherlands with low-risk Barrett's esophagus who have stopped having routine endoscopic surveillance. The goal is to see if stopping these regular scopes leads to a rise in serious esophageal cancer cases over 10 years. Participants do…

This study will collect data from 90,000 adults to compare two methods of taking tissue samples from the esophagus: standard forceps biopsies and a brush-based method called WATS3D. The goal is to see which approach better detects Barrett's esophagus, dysplasia, and other esophag…

This study is testing a new swallowable capsule that uses light-based imaging (OCT) to find and collect abnormal tissue in people with Barrett's esophagus, a condition that can lead to esophageal cancer. The goal is to see if the capsule can successfully grab tissue samples for g…

This study looks at the best way to manage Barrett's esophagus with low-grade dysplasia, a condition where the esophagus lining has abnormal but not yet cancerous cells. Researchers will compare two common approaches: regular check-ups with biopsies (surveillance) versus a proced…

This study watches how the esophagus changes in people getting radiofrequency ablation for Barrett's esophagus, a condition that can lead to cancer. Ten adults will have extra measurements taken during their routine endoscopies. The goal is to gather information that could help p…