Could a simple sponge replace endoscopy for esophageal cancer screening?
NCT ID NCT06071845
First seen Jan 11, 2026 · Last updated Jun 19, 2026 · Updated 28 times
Summary
This trial is testing a new, less invasive way to detect Barrett's esophagus, a condition that can lead to esophageal cancer. Participants swallow a capsule attached to a string that expands into a sponge in the stomach, collecting cells as it is pulled back up. The goal is to see if this Cytosponge device can accurately identify Barrett's esophagus compared to standard endoscopy, potentially making screening easier and more accessible for at-risk patients.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Long Island Jewish Medical Center | Northwell Health
COMPLETEDNew Hyde Park, New York, 11040, United States
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Mayo Clinic
RECRUITINGScottsdale, Arizona, 85259, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Mayo Clinic in Florida
RECRUITINGJacksonville, Florida, 32224, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Northwestern University
TERMINATEDChicago, Illinois, 60611, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cytosponge device
What this could lead to
If successful, this could provide a simple, non-endoscopic screening test for Barrett's esophagus, enabling earlier detection and reducing the need for invasive procedures.
What could go wrong
This is an early-stage accuracy study (not a treatment trial), and the test may not be sensitive or specific enough to replace endoscopy. Results are compared to a previous device, so performance may vary.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.