New cutting tool may outperform heat therapy for Barrett's esophagus
NCT ID NCT04867590
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This study tests a new device called EndoRotor, which mechanically removes the damaged lining of the esophagus, against the standard heat-based radiofrequency treatment for people with Barrett's esophagus who have precancerous cells (dysplasia). The goal is to see if the new method can completely eliminate the abnormal tissue in a single session, while also allowing for tissue analysis. About 140 adults with Barrett's esophagus measuring 2 to 6 cm will take part, and the main check happens 3 months after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- EndoRotor device (mechanical mucosal resection system)
- What this could lead to
- If successful, EndoRotor could offer a more effective, one-session treatment for Barrett's esophagus, potentially reducing the risk of hidden precancerous glands and lowering costs.
- What could go wrong
- This is a relatively early comparison study with 140 participants. The new technique may not prove superior, and carries risks like perforation or bleeding. Long-term outcomes are not yet known.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cochin Hospital
ACTIVE_NOT_RECRUITINGParis, France
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Edouard Herriot Hospital
RECRUITINGLyon, France
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Georges Pompidou European Hospital
WITHDRAWNParis, France
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UNiversity Hospital of Toulouse
RECRUITINGToulouse, France
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University Hospital of Besançon
RECRUITINGBesançon, France
-
University Hospital of Bordeaux
RECRUITINGPessac, France
-
University Hospital of Brest
NOT_YET_RECRUITINGBrest, France
-
University Hospital of Dijon
RECRUITINGDijon, France
-
University Hospital of Lille
RECRUITINGLille, France
-
University Hospital of Limoges
RECRUITINGLimoges, France
-
University Hospital of Montpellier
RECRUITINGMontpellier, France
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University Hospital of Nancy
RECRUITINGNancy, France
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University Hospital of Nantes
RECRUITINGNantes, France
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University Hospital of Nice
NOT_YET_RECRUITINGNice, France
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University Hospital of Poitiers
NOT_YET_RECRUITINGPoitiers, France
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University Hospital of Rennes
NOT_YET_RECRUITINGRennes, France
-
University Hospital of Tours
RECRUITINGChambray-lès-Tours, France
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