University Hospital, Angers

This study tests a new device called EndoRotor, which mechanically removes the damaged lining of the esophagus, against the standard heat-based radiofrequency treatment for people with Barrett's esophagus who have precancerous cells (dysplasia). The goal is to see if the new meth…

This study compares a daily pill (rivaroxaban) to daily injections (low-molecular-weight heparin) for preventing blood clots in people with leg injuries that require a cast or brace. About 1,424 high-risk participants will be randomly assigned to one of the two treatments and fol…

This study compares changing IV tubing every 7 days versus every 4 days in ICU patients with central venous catheters. The goal is to see if the longer interval increases infection rates. About 2,830 adults will take part. If 7-day changes are safe, it could save nursing time and…

This study looks at whether offering personalized follow-up, including video visits, helps more people with pseudoxanthoma elasticum (PXE) get proper care. PXE causes calcium buildup in skin, eyes, and blood vessels, leading to vision loss and other problems. The researchers will…

This study tests whether a custom mouthpiece (mandibular advancement device) can help people with obstructive sleep apnea when they temporarily stop using their CPAP machine. Forty adults who normally use CPAP will either use the mouthpiece or nothing during a two-week CPAP break…

This study tests a treatment called extracorporeal phototherapy (ECP) for people whose kidney transplants are failing due to chronic antibody-mediated rejection. ECP involves taking a patient's blood cells, treating them with a light-activated drug and UVA light, then returning t…

This study tests whether giving stroke patients a personalized diet plan within two days can lower the risk of death within 30 days. About 3,084 adults with moderate to severe stroke will take part. Dietitians will track food intake and adjust nutrition, using supplements or tube…

This study tests whether using a simple early warning score (NEWS) to quickly move high-risk blood cancer patients to the ICU can reduce deaths and organ failure. Over 2,200 adults receiving intensive chemotherapy or stem cell transplants will take part across ten hospitals. Half…

This study tests whether better teamwork between doctors, physiotherapists, and workplace health services can help people with low back pain avoid long-term disability. About 500 adults with subacute or recurrent low back pain who are still working will receive either standard ca…

This study aims to see which of two blood tests, eLIFT or FibroMeter, is better at finding advanced liver scarring (fibrosis) in people with fatty liver disease or alcohol-related liver disease. About 1,788 adults from primary care clinics will take both tests. The goal is to imp…

This study investigates whether adding RNA sequencing to standard DNA sequencing can help identify genetic causes of neurodevelopmental disorders that also involve physical birth defects. Many children with these conditions go years without a clear diagnosis. The research compare…

This study explores whether measuring stomach size with ultrasound can predict nausea, vomiting, and pneumonia after major abdominal surgery. Researchers will compare stomach diameter before and after surgery in 150 patients. The goal is to find a simple way to identify who might…

This study tests a new way to diagnose knee sprains using a quick scan called Automated Dynamic Laximetry (LDA) instead of the usual MRI. About 80 adults with suspected ACL injuries will be split into two groups: one gets LDA first, the other gets MRI. The goal is to see if LDA c…

This study is testing whether a common blood test, called FIB4, can help find people with advanced liver fibrosis (serious liver scarring) who don't know they have it. About 500 adults aged 18-70 with a high FIB4 result will get a more detailed liver check, including a special ul…

This study compares two step-by-step approaches to diagnose advanced liver fibrosis in people with NAFLD (fatty liver disease). Both methods start with a simple blood test, then use a more advanced test only if needed, aiming to avoid invasive liver biopsies. About 1,045 particip…

This study is testing whether a high-resolution EEG (HR-EEG) can better predict which children with drug-resistant focal epilepsy will have successful surgery. About 120 children will have a painless HR-EEG recording before surgery. Researchers will compare the pattern of brain s…

This study tests a new type of hospital room, called Hospi'Senior, designed specifically for elderly patients. The room includes better lighting, easier-to-use furniture, and technology to help patients move around more easily. Researchers want to see if this room can shorten hos…

This pilot study tests whether a 10-week treadmill training program combined with blood flow restriction (using cuffs on the legs) can safely improve walking speed in 13 children aged 8 to 18 with cerebral palsy. The children will walk on a treadmill three times a week, gradually…

This study looks at whether medical honey can help heal wounds in intensive care patients better than standard care. About 60 adults with fresh wounds (like pressure sores or cuts) will be randomly assigned to get either honey dressings or usual treatment. The main goal is to see…

This pilot study tests whether doing simple eye exercises on a touchscreen for 30 minutes every other day can improve attention and thinking speed in people aged 60 and older with mild cognitive impairment. Forty participants will either do the visual exercises or watch a TV prog…

This study compares two types of exercise-video game (exergame) programs for people with Huntington's disease. One program mixes physical and mental exercises together, while the other does them separately. Researchers want to see which approach improves balance, thinking, and da…

This study tests a new home-based program that uses a special treadmill and virtual reality to help children with conditions like cerebral palsy, muscle diseases, or obesity improve their walking. About 30 children aged 6 to 17 will try the program at home for at least 3 sessions…

This study tests whether regular karate practice can improve quality of life, self-esteem, and sleep in medical students, who often face high stress and anxiety. Researchers will enroll 90 third- or fourth-year health students at the University of Angers. Participants will practi…

This study tests whether people with liver cancer can be safely treated as outpatients instead of staying in the hospital after a procedure that delivers treatment directly to the liver's blood supply. About 206 patients will be randomly assigned to either outpatient or standard …

This study collects blood, urine, and skin samples from people with rare genetic diseases whose genetic cause is not yet known. The goal is to build a biobank that researchers can use to confirm whether certain gene variants are responsible for these diseases. By identifying new …

This study looks at the best time to resume sexual activity after a hysterectomy (surgery to remove the uterus). Currently, there is no standard advice. The researchers will randomly assign 142 women to either wait 4 weeks or 8 weeks before having sex again. They will measure sex…

This study is testing how to safely perform skin allergy tests in people receiving biotherapies for cancers and blood disorders. Researchers will find the highest concentration of each biotherapy that does not cause a skin reaction in 9 out of 10 patients. The goal is to establis…

This study is testing a new questionnaire called PETRA that uses pictures to help people with suspected thoracic outlet syndrome describe which daily tasks they avoid because of their symptoms. The questionnaire also asks how often they face those tasks, giving doctors a clearer …

This study looks at whether giving extra oxygen through a mask (normobaric oxygen therapy) can help people with critical limb ischemia, a severe lack of blood flow to the legs that can lead to amputation. Researchers will compare the health and treatments of 200 patients who do o…

This study looks at whether new MRI techniques can spot NASH, the serious form of fatty liver disease, without needing a liver biopsy. Researchers will scan 110 adults who already need a biopsy to see if the MRI can match the biopsy results. If successful, it could lead to a safe…

This study looks at a newly identified condition called FIRE (Food Induced Immediate Response of the Esophagus) in children with eosinophilic esophagitis. Researchers want to find out how common FIRE is and describe its symptoms, like chest pain or choking within minutes of eatin…

This study follows 9 healthy young adults living for one year on the remote Kerguelen Islands to see how extreme isolation and stress affect their immune system. Researchers will collect blood, saliva, stool, urine, and hair samples every three months to measure immune cells, str…

This study is testing a new, simple questionnaire called SAPHIR to see if it can accurately measure how physically active people are. Researchers will compare the questionnaire results with data from an activity monitor worn by 118 adults. The goal is to create an easy tool for d…

This study is collecting blood, urine, and stool samples from 300 people with cirrhosis to build a biobank. Researchers will later use these samples to understand how factors like nutrition, physical activity, smoking, alcohol, and pollution influence the development of the most …

This study aims to find blood-based biomarkers that can predict whether a child with acute disseminated encephalomyelitis (ADEM) will experience relapses. Researchers will analyze immune cells from blood samples of 20 children aged 1-18 with a first demyelinating event. The goal …

This study follows children and teens who had radiation to the brain before age 16 to check for hormone problems. Researchers will measure hormone levels and track fatigue to create better follow-up guidelines. About 230 participants in remission from cancer will be monitored for…

This study looks at whether repeated sessions of hyperbaric oxygen therapy (HBOT) can damage DNA in people who have had radiation for cancer. HBOT is used to help heal tissues damaged by radiation, but it also creates reactive oxygen molecules that might harm DNA. Researchers wil…

This study looks at whether raising blood pressure to a higher target (80-85 mmHg) improves kidney function in adults with shock and high central venous pressure. About 30 participants will be monitored. The goal is to learn if personalized blood pressure targets can protect the …

This study compares how people with chronic insomnia and healthy controls recognize facial emotions. Using eye-tracking, researchers will look for subtle differences in attention and emotional processing. The goal is to better understand social challenges linked to insomnia and i…

This study looks at how specific genetic changes (ASXL1 mutations) affect the course of myelofibrosis, a rare bone marrow cancer. Researchers will analyze blood and bone marrow samples from 50 adults to identify different patterns of these mutations. The goal is to better predict…

This study is for adults with polycythemia vera, essential thrombocythemia, or pre-myelofibrosis who are starting their first treatment. Researchers want to find out why some patients respond well to standard drugs while others do not. They will look at genetic and immune system …

This study looks at memory, concentration, and language problems caused by chemotherapy in people with blood cancers like leukemia and lymphoma. Researchers will compare 120 patients to their healthy relatives using tests and questionnaires before and after treatment. The goal is…

This study looks at whether changes in the level of a specific gene mutation (CALR) in the blood can help predict when certain blood cancers (myeloproliferative neoplasms) get worse. Researchers will collect blood samples from 260 adults diagnosed between 2006 and 2020 and track …

This study tracks 1,650 people who had a first heart attack to see if men and women's hearts change shape and size differently during recovery. Using repeated heart scans (echocardiograms and MRIs), researchers aim to understand why women tend to have worse outcomes like heart fa…

This study looks at whether people with a rare inherited movement disorder called spinocerebellar ataxia have trouble recognizing emotions or understanding social situations. Researchers will compare 160 patients to healthy volunteers using tests like recognizing facial expressio…

This study is looking at whether regularly checking the amount of pembrolizumab in the blood of people with non-small cell lung cancer can help doctors tailor treatment. The goal is to see if this monitoring can improve how well the drug works and reduce side effects. The trial w…

This study looks at two different approaches to deciding when to place a breathing tube in patients with acute hypoxemic respiratory failure (dangerously low oxygen levels). One strategy is more liberal (intubate earlier to prevent complications from low oxygen), while the other …

This study looks at how two different levels of breathing support (called PEEP) affect lung function in patients with a severe lung condition called ARDS. The researchers want to see if the response differs based on the patient's lung stiffness. They will use a special imaging te…

This study looks at whether adding certain nutrients to blood cells from people with septic shock can help restore the cells' energy-making machinery (mitochondria). Researchers will collect blood samples from 55 patients in the ICU and test these nutrients in the lab. The goal i…

This study looks at whether a special eye scan can detect early blood flow changes in the retina of people with pseudoxanthoma elasticum (PXE), a rare genetic disease that can cause vision loss. Researchers will compare 30 PXE patients with 30 healthy volunteers matched by age an…

This study looks at a type of immune cell called monocytes in people with certain blood cancers (polycythemia vera, essential thrombocythemia, and myelofibrosis). Researchers will analyze blood samples from 70 newly diagnosed patients to find unique patterns in these cells. The g…

This study looks at whether the amount and type of gas a person passes after abdominal surgery can help predict complications. Researchers will track 200 adults before and after surgery, asking them to record details about their gas. The goal is to see if gas quality can serve as…

This study is testing whether continuously measuring oxygen levels in urine can help predict when a patient in shock will develop acute kidney injury or recover from it. Researchers will monitor 55 intensive care unit patients with and without shock. The goal is to see if urine o…