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Could skipping random biopsies during colonoscopy be just as safe for IBD patients?

NCT ID NCT05809999

Completed Knowledge-focused Sponsor: Ottawa Hospital Research Institute Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study compares two ways of doing colonoscopy in people with inflammatory bowel disease (IBD) who are at higher risk for colon cancer. One method takes biopsies only from visible abnormal areas, while the other also takes random biopsies from normal-looking tissue. The goal is to see if the simpler approach misses any pre-cancerous growths. About 1,400 adults with IBD will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If skipping random biopsies proves non-inferior, future IBD surveillance could be faster and less invasive without missing dangerous growths.
What could go wrong
This is a non-inferiority trial, so it may show that skipping random biopsies misses some pre-cancerous lesions. Results may not apply to all IBD patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colonic neoplasm inflammatory bowel disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLONIC NEOPLASMS DYSPLASIA INFLAMMATORY BOWEL DISEASES

Contacts and locations

Locations

  • Eastern Regional Health Authority

    St. John's, NFLD, A1B 3V6, Canada

  • Hamilton Health Sciences

    Hamilton, Ontario, L8L 8E7, Canada

  • London Health Sciences Centre, University Hospital

    London, Ontario, Canada

  • McGill University Health Centre

    Montreal, Quebec, Canada

  • Mount Sinai Hospital

    Toronto, Ontario, Canada

  • Nova Scotia Health Authority

    Halifax, Nova Scotia, Canada

  • Ottawa Hospital Research Institute

    Ottawa, Ontario, K1H 8L6, Canada

  • St. Paul's Hospital

    Vancouver, British Columbia, Canada

  • Thunder Bay Regional Health Sciences Centre

    Thunder Bay, Ontario, Canada

  • University of Alberta

    Edmonton, Alberta, Canada

  • University of Manitoba, Health Sciences Centre

    Winnipeg, Manitoba, Canada

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