Can a laser scan catch mouth cancer before it spreads?
NCT ID NCT07110623
First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time
Summary
This trial tests a device that uses a laser to scan the inside of the mouth and help detect pre-cancer and cancer. Currently, doctors rely on their eyes to decide where to take a biopsy, which can miss early signs. The device collects molecular information from the tissue, and the study aims to train its software to recognize cancerous changes. Adults scheduled for an oral biopsy, plus healthy volunteers, will be scanned, and the results will be compared with biopsy reports.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- LIP device, a non-invasive laser scanner using polarized Raman spectroscopy to analyze mouth tissue
- What this could lead to
- If it works, this device could help doctors spot oral cancer earlier and guide biopsies more accurately, improving treatment success.
- What could go wrong
- This is a small pilot study focused on training the software, not proving it works in practice. The device may not reliably distinguish cancer from healthy tissue, and safety data is limited.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
-
40 people
The number who actually took part.
- Started
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Dec 2025
- Finished
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Aug 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Participants will be recruited from a single site at Guy's Hospital (London, UK). Patients with suspected pre-malignant or malignant condition (ie. having a "suspicious lesion") will be recruited from oral medicine and dental clinics at Guy's Hospital (London, UK) during their hospital appointment. Healthy volunteers will be recruited from staff and students at KCL and GSTT.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria for patients 1. Adult aged 18 and older 2. One of the following criteria must be met: 1. Has a medical condition for which biopsy of oral tissue has been indicated. 2. Is undergoing inspection for early oral cancer 3. Willing and able to comply with all study procedures. Exclusion criteria for patients 1. Has a bleeding disorder, such as haemophilia, or has contraindication for having a biopsy. 2. Severe co-morbid illness, such as end-stage renal failure (ESRF), congestive cardiac failure (CCF), severe osteoarthritis (OA) and rheumatoid arthritis (RA) requiring long term non-steroidal anti-inflammatory drug (NSAID) therapy and any other immunosuppression / immuno-modulation therapy. 3. Has other severe acute or chronic medical or psychiatric condition where use of the device may cause unnecessary stress 4. Any condition that under judgment of the investigator would make the subject unsuitable as it may interfere with interpretation of study results 5. Currently using any compound recognised as acting as a light sensitizer / has a recognised condition associated with light sensitisation / tissue sensitivity to light such as photodynamic therapy or lupus. 6. Is pregnant or breastfeeding 7. Has a laboratory abnormality in medical record that may interfere with the interpretation of study results Inclusion criteria for healthy volunteers 1. Adult aged 18 and older. 2. Willing and able to comply with all study procedures. Exclusion criteria for healthy volunteers 1. Has a medical condition for which biopsy has been indicated or is undergoing inspection for early cancer. 2. Severe co-morbid illness, such as end-stage renal failure (ESRF), congestive cardiac failure (CCF), severe osteoarthritis (OA) and rheumatoid arthritis (RA) requiring long term non-steroidal anti-inflammatory drug (NSAID) therapy and any other immunosuppression / immuno-modulation therapy. 3. Has other severe acute or chronic medical or psychiatric condition where use of the device may cause unnecessary stress 4. Any condition that under judgment of the investigator would make the subject unsuitable as it may interfere with interpretation of study results 5. Currently using any compound recognised as acting as a light sensitizer / has a recognised condition associated with light sensitisation / tissue sensitivity to light such as photodynamic therapy or lupus. 6. Is pregnant or breastfeeding
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Oral Clinical Research Unit, Guy's Hospital
London, Surrey, SE1 9RT, United Kingdom
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