King's College London

This study is testing if adding the antibiotic minocycline to standard antidepressants is a practical and acceptable approach for people who have both obesity and depression that hasn't responded to other treatments. Researchers want to see if participants can complete the 8-week…

This study is testing whether adding a special heat treatment to standard palliative radiotherapy helps control advanced cancers that cannot be cured by surgery. It will involve about 60 patients with certain advanced head, neck, skin, or breast cancers. The goal is to see if the…

This study aims to help young people with ADHD better manage their condition during the challenging transition from adolescence to adulthood. Researchers will remotely monitor 250 teens with ADHD for two years using smartphone apps and wearable devices to track symptoms and lifes…

This study is testing if a drug called diroximel fumarate, currently used for multiple sclerosis, can increase levels of a protective brain chemical called glutathione in people with schizophrenia. Researchers will use brain scans and other tests on 30 participants to see if the …

This UK trial is testing whether a home-use brain stimulation device can help people with depression. The device, called tDCS, delivers a mild electrical current through a headset. Researchers want to see if using it at home for 10 weeks, along with a person's usual care, is bett…

This large trial is testing whether taking capsules containing processed stool from healthy donors can help people with advanced liver scarring (cirrhosis) avoid serious infections that lead to hospital stays. About 300 participants will take either the real capsules or placebo p…

This large study aims to find out how safe and effective newer medical devices are for treating brain aneurysms, which are weak spots in brain arteries that can burst and cause strokes. It will follow 5,000 patients who receive these treatments to see which factors, like smoking,…

This study is testing a digital therapy program called SloMo, which is designed to help people with psychosis manage paranoid thoughts and improve their wellbeing. It involves 150 participants working with trained therapists in the NHS to use an app that teaches techniques to slo…

This study is testing whether tiny ultrasound bubbles injected into the bloodstream can accurately measure pressure inside the heart, potentially replacing invasive catheter procedures. Researchers will compare bubble measurements against traditional catheter readings in 10 patie…

This study is testing whether a self-guided smartphone app based on therapy principles is a practical and helpful tool for people with long-term physical conditions who are also experiencing depression or anxiety. Sixty UK residents will try the app for 12 weeks while others use …

This study is testing whether structured dance and movement therapy is a practical and acceptable approach for people with functional neurological disorder (FND). Researchers will enroll 30 adults with FND to compare the dance therapy to a standard physical exercise program. The …

This study is testing whether taking a collagen supplement for 8 days can improve quality of life, appetite, and blood sugar levels in overweight adults. One hundred participants will take either the collagen supplement or a placebo, fill out questionnaires about their mood and e…

This study aims to understand how psilocybin, the active compound in psychedelic mushrooms, affects brain networks in people with functional neurological disorder (FND). Researchers will use MRI brain scans before and after a single dose to see if psilocybin changes specific brai…

This study aims to discover the genetic causes of Juvenile Myoclonic Epilepsy (JME), a common form of epilepsy that starts in childhood. Researchers are collecting blood samples, medical information, and brainwave test results from 1000 people with JME across multiple countries. …

This study is testing whether a brief online educational video can help heavy, daily cannabis users become more aware of withdrawal symptoms and their own usage patterns. Researchers will recruit about 100 adults who use cannabis nearly every day. Participants will be randomly as…

This study aims to understand how brain energy use and chemicals differ in people with schizophrenia compared to healthy volunteers. Researchers will use advanced brain scans to measure glucose usage, lactate levels, and glutamate activity in 75 participants. The goal is to gathe…

This study aims to see if small, lab-grown models of a patient's tumor, called organoids, can predict how well cancer treatments will work for them. Researchers will create these models from tissue samples of 20 breast cancer patients whose cancer has spread. They will test diffe…

This study aims to understand how the body's immune system influences psychosis symptoms and how people respond to antipsychotic medications. Researchers will collect blood and spinal fluid samples from 500 people with psychosis symptoms who are starting or changing medications, …

This study aims to understand how regular skin massage affects a baby's developing immune system and skin health. Researchers will enroll 109 healthy babies up to 6 months old and randomly assign them to receive no massage, massage twice a week, or daily massage for 8 weeks. The …

This study aims to find out how common high blood pressure is in children and teenagers who are at risk for an inherited kidney disease called ADPKD. Researchers will recruit 200 young people (ages 12-17) who have a parent with ADPKD. Participants will have their blood pressure c…

This study aims to create better guidance for nurses to spot early skin changes caused by chronic vein disease in people with darker skin tones. Researchers will interview patients about their experiences and test different skin examination and photography techniques. The goal is…

This study is testing whether a smartphone app called 'HappyMums' can help researchers learn more about depression during pregnancy. It will enroll 1,000 pregnant people who are at risk for or currently experiencing depression. The app collects data through activities, questionna…