King's College London

This study tests whether taking capsules containing healthy donor stool (fecal transplant) can help prevent serious infections and hospital stays in people with liver cirrhosis. About 300 adults with alcohol-related or fatty liver disease will receive either the transplant or a p…

This study tests whether a daily probiotic drink can improve immune function and reduce skin inflammation in women aged 40-60 going through menopause. Participants will drink either a probiotic or a plain milk drink for 8 weeks. Researchers will measure immune aging, inflammation…

This study tests whether adding a special heat treatment (water-filtered infrared-A, or wIRA) to standard palliative radiation can help shrink tumors and ease symptoms in people with advanced head, neck, or skin cancers that cannot be cured. About 60 adults will receive the combi…

This study looks at whether opening blocked heart arteries with stents can improve quality of life for people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart muscle is stiff. About 350 adults with both HFpEF and coronary artery disease wil…

This study tests whether adding the antibiotic minocycline to usual antidepressants can help people who have both obesity and treatment-resistant depression. Researchers believe that inflammation may play a role in these conditions, and minocycline can reduce inflammation. The st…

This study tests whether taking a collagen supplement for 8 days can improve quality of life, appetite, and blood sugar in overweight or obese adults aged 18-65. Participants will take the supplement or a placebo, fill out questionnaires about their mood and energy, and wear a co…

This study tests whether a safe, non-invasive brain stimulation method called tDCS can reduce depression symptoms when used at home. About 438 adults with moderate to severe depression will either receive tDCS plus their usual care or just usual care for 10 weeks. The goal is to …

This study explores whether structured dance or movement therapy is a practical and helpful treatment for adults with functional neurological disorder (FND), a condition where the brain doesn't send proper signals to the body. Researchers will compare dance therapy to regular phy…

This study tests whether a smartphone app called Orbi can help people with long-term physical illnesses manage feelings of distress, anxiety, or depression. About 60 adults in the UK will either use the app plus usual charity support, or just charity support, then switch after 12…

This study tests a digital therapy called SloMo for people with psychosis who worry about harm from others (paranoia). The therapy uses an app and therapist sessions to help people slow down fast thinking and feel safer. 150 participants will receive the therapy from NHS therapis…

This study tests whether a safe, non-invasive brain stimulation device used at home can reduce depression in people with bipolar disorder. About 212 adults with bipolar depression will either receive real or sham (fake) stimulation for 10 weeks. The goal is to see if the device i…

This study compares brain energy use, lactate, and glutamate levels between 75 people with schizophrenia and healthy volunteers. Participants undergo MRI and PET scans to measure these factors. The goal is to better understand the biology of schizophrenia, not to test a treatment…

This study aims to improve how doctors spot early signs of chronic venous insufficiency (CVI) in people with dark skin tones. Researchers will interview patients about their experiences and test new assessment techniques, including touch and special photography. The goal is to re…

This early study tests if ultrasound contrast agents (microbubbles) can estimate pressure inside the heart, potentially replacing the need for a catheter. Ten adults with suspected heart disease will receive a standard contrast injection and an ultrasound scan. Researchers will c…

This study looks at how the immune system might influence psychotic symptoms and how well antipsychotic medications work. Researchers will collect blood and spinal fluid from 500 people with psychosis who are starting or changing medication, plus a healthy comparison group. The g…

This study tracks 5,000 people who have had a brain aneurysm treated with new medical devices. Researchers want to learn what makes aneurysms come back, like smoking. The goal is to improve future treatments, not to test a new drug or cure.

This study looks at children and teens (ages 12-17) who have a parent with a kidney disease called ADPKD. The goal is to find out how many of them have high blood pressure and to test if MRI scans can spot the disease as well as genetic testing. Participants will have blood press…

This study looks at whether diroximel fumarate, a drug already used for multiple sclerosis, can increase glutathione—a key antioxidant—in the brains of people with schizophrenia. Thirty adults with stable schizophrenia will take the drug for two weeks, then either continue it or …

This study tracks 250 teens with ADHD (aged 16-17) over two years using smartphone apps and a Fitbit to monitor symptoms, sleep, and activity. The goal is to understand what changes happen during this transition, what predicts problems, and how to prevent negative outcomes. Resea…

This study tests whether a brief online video about cannabis withdrawal can help daily users become more aware of their cannabis use. About 100 adults who use cannabis at least 25 days a month will watch either an educational video or a relaxation video. The goal is to see if the…

This study takes small samples of breast cancer that has spread to the brain or other organs and grows them in the lab. Researchers will test different treatments on these lab-grown models to see if they can predict how the patient's own cancer will respond. The goal is to learn …

This study looks at how regular skin massage might change the immune system in healthy babies up to 6 months old. Researchers will compare daily massage, twice-weekly massage, and no massage over 8 weeks to see if it affects skin inflammation and barrier function. The goal is to …

This study is testing whether pregnant women at risk of depression are willing to use a mobile app called HappyMums throughout their pregnancy. The app collects mental health data through questionnaires and phone usage. Researchers hope this information can one day help predict a…

This study is collecting blood samples, brain wave data, and medical information from over 1,000 people with Juvenile Myoclonic Epilepsy (JME) across the UK, Europe, and North America. Researchers will compare this data with anonymous samples from 2,000 people without JME. The go…