King's College London

This study tests whether taking capsules of processed donor stool (fecal transplant) can help people with liver cirrhosis avoid serious infections and hospital stays. About 300 adults with alcohol-related or fatty liver cirrhosis will receive either the transplant or a placebo an…

This study tests whether ultrasound contrast agents (microbubbles) can estimate pressure inside the heart, potentially replacing invasive catheters. Ten adults with suspected heart disease will receive a standard ultrasound with contrast while also having a catheter for compariso…

This study tests whether a daily snack rich in plant chemicals and fibre can ease perimenopause symptoms like hot flushes, mood changes, and sleep problems. Twenty women aged 40-55 who are not on hormone therapy will eat either the special snack or a placebo for several weeks, th…

This study tests whether a daily probiotic drink can improve immune function and reduce skin inflammation in women aged 40-60 going through menopause. Participants will drink either a probiotic or a plain milk drink for 8 weeks. Researchers will measure immune aging, inflammation…

This study looks at whether placing stents in blocked heart arteries can improve quality of life for people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart muscle is stiff. About 350 participants will be randomly assigned to receive either…

This study tests whether a portable, home-use brain stimulation device (tDCS) can safely reduce depressive symptoms in people with bipolar disorder. 212 adults with bipolar depression will use either the active device or a sham (placebo) version at home for 10 weeks. The goal is …

This study tests SloMo, a digital therapy that helps people with psychosis who fear harm from others. It combines face-to-face sessions with a mobile app to help users notice worries and slow down fast thinking. 150 participants across three NHS trusts will try the therapy, with …

This study tests a safe, non-invasive brain stimulation treatment called tDCS that people can use at home to ease depression. About 438 adults with major depression will either receive active tDCS plus their usual care, or just usual care alone. The goal is to see if adding tDCS …

This study tests whether adding a special heat treatment (water-filtered infrared, or wIRA) to standard palliative radiation can help shrink tumors and ease symptoms in people with advanced head, neck, or skin cancer that cannot be cured. About 60 adults will receive the combined…

This study tests whether taking a collagen supplement for 8 days can improve quality of life, appetite, mood, and blood sugar control in overweight or obese adults aged 18-65. Participants will take the supplement or a placebo, fill out questionnaires, and wear a continuous gluco…

This study looks at whether minocycline, an antibiotic that reduces inflammation, can help people who have both obesity and depression that hasn't improved with other treatments. Researchers will test if this approach is practical and acceptable for 35 participants. The goal is t…

This study tests a smartphone app called Orbi, which uses cognitive behavioural therapy (CBT) to help people with long-term physical conditions cope with depression and anxiety. 60 participants will either use the app plus usual charity support, or charity support alone, then swi…

This study looks at how THC and CBD, two compounds found in cannabis, affect the body's stress response in people who are sleep-deprived and have higher-than-average anxiety. Sixty healthy volunteers will take either THC, CBD, both, or a placebo after a night of restricted sleep.…

This study looks at how eating more plant foods changes the bacteria in your gut and affects your heart health. Healthy adults aged 30 to 70 who eat few plants will get all their meals from the study team for four weeks. Researchers will measure gut bacteria, blood, and other hea…

This study investigates how the immune system influences psychotic symptoms and response to antipsychotic medication. Researchers will collect blood and spinal fluid from 500 participants, including those starting or changing antipsychotics and healthy controls. The goal is to fi…

This study tests whether diroximel fumarate, a drug already used for multiple sclerosis, can increase levels of the antioxidant glutathione in the brains of people with schizophrenia. Thirty participants will take the drug for two weeks, then be randomly assigned to continue the …

This study looks at how regular skin massage affects the immune system of healthy babies up to 6 months old. Researchers will compare daily massage, twice-weekly massage, and no massage over 8 weeks to see if massage changes immune signals in the skin. The goal is to understand i…

This study tests whether a brief online video about cannabis withdrawal can increase awareness and insight in people who use cannabis daily. Researchers will recruit 100 heavy users (at least 25 days per month and 3.5 grams per week) through an online platform. Participants will …

This study is growing miniature versions of breast cancer tumors, called organoids, from samples taken during surgery. Researchers want to see if these lab-grown organoids can predict how well a patient's cancer will respond to treatments like chemotherapy or radiation. If the or…

This study will see if 1000 pregnant women at risk of depression are willing to use a mobile app called HappyMums throughout their pregnancy. The app collects mental health data through questionnaires and phone usage. Researchers hope this information can help predict and better …

This study aims to find out how common high blood pressure is in children and teenagers (ages 12-17) who are at risk for autosomal dominant polycystic kidney disease (ADPKD) because a parent has it. Researchers will use MRI scans and genetic tests to detect early signs of the dis…

This study tracks 250 teens with ADHD aged 16-17 over two years using smartphone apps and a Fitbit. The goal is to understand what changes happen during this transition and what predicts negative outcomes. Researchers will then co-design a smartphone app with teens to help them m…

This study will follow 5,000 people who receive newer endovascular devices (like coils, stents, or flow diverters) to treat a brain aneurysm. Researchers want to see how often the aneurysm comes back and what factors, such as smoking, might play a role. The goal is to improve saf…

This study from King's College London focuses on how to better identify early skin changes from chronic venous insufficiency (CVI) in people with dark skin tones. Researchers will interview patients about their experiences and test new assessment techniques, like using touch and …

This study aims to find the genetic causes of juvenile myoclonic epilepsy (JME) by collecting blood samples from over 1,000 people with JME across the UK, Europe, and North America. Researchers will compare their DNA to samples from 2,000 healthy controls. The goal is to improve …

This study compares brain energy use, lactate, and glutamate levels in 75 people with schizophrenia and healthy volunteers using advanced MRI and PET scans. Researchers aim to see if brain glucose use is lower and lactate higher in schizophrenia, and if glutamate varies more. No …