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Immune clues could revolutionize psychosis care

NCT ID NCT06687694

Recruiting now Knowledge-focused Sponsor: King's College London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates how the immune system influences psychotic symptoms and response to antipsychotic medication. Researchers will collect blood and spinal fluid from 500 participants, including those starting or changing antipsychotics and healthy controls. The goal is to find biomarkers that help diagnose, predict, and track treatment response, potentially leading to targeted immune-based therapies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to immune-based treatments for psychosis and better ways to choose the right antipsychotic for each patient.
What could go wrong
This is an observational study, not a treatment trial. It is early-stage research, and findings may not directly lead to new therapies or apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar disorder depressive disorder Inflammation Mania mood disorder psychiatric disorder psychotic disorder Psychotic Disorders Schizophrenia schizotypal personality disorder Shared Paranoid Disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PSYCHOSIS

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • South London and Maudsley NHS Foundation Trust

    RECRUITING

    London, United Kingdom, SE5 8AB, United Kingdom

    Contact Email: •••••@•••••

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