Plant-Powered study seeks to unlock gut health secrets
NCT ID NCT07586111
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how eating more plant foods changes the bacteria in your gut and affects your heart health. Healthy adults aged 30 to 70 who eat few plants will get all their meals from the study team for four weeks. Researchers will measure gut bacteria, blood, and other health markers to compare two different plant-rich diets.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 248 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Nov 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 30-70 years of age * Capacity to give informed consent in English * Consume equal or less than the average UK plant food intake (number and quantity) * Consume less than 30 g/d of fibre * BMI 18.50-29.99 kg/m2 * Willing to complete the trial by adhering to the diet intervention, complete questionnaires, provide stool, urine and blood samples, record weight and other anthropometric values and record food intake throughout the study * Willing and able to adhere to the protocol for the diet intervention for the whole duration of the trial (e.g., appropriate space in freezer to store meals, access to oven/microwave, no planned travelling) * Willing to discontinue use of prebiotics and probiotics 4 weeks prior and during the intervention period * Willing to consume animal products daily * Medication use is stable in women receiving hormone replacement therapy (stable use for the past 3 months) Exclusion Criteria: * Medical history of any of the following: diabetes, major active or historic psychiatric conditions (e.g., schizophrenia), current eating disorder, alcohol abuse, active treatment for cancer in the last year, severe neurological, endocrine, renal, cardiac or pulmonary disease (or any other chronic medical condition), severe oesophagitis, gastritis or duodenitis, active diverticulitis or intestinal/colonic strictures, Coeliac disease, Crohn's disease or Ulcerative colitis, stem cell or organ transplant, gut resection surgery (excluding appendicectomy and cholecystectomy), bleeding disorder, anaphylaxis or any other major or chronic condition known to impact study outcome measures. * A current diagnosis of IBS, as defined by the Rome IV criteria. * Taking medications known to affect outcomes of interest, including: * Prebiotics and probiotics 4 weeks prior to enrolment. * Antibiotics within 4 weeks of enrolment. * Medications known to affect blood pressure, appetite, gut motility, glucose control, or lipid levels within 4 weeks of enrolment. * Taking any dietary supplements, apart from vitamin D or calcium supplements, 4 weeks prior to enrolment. * Allergy or intolerance to any study food ingredients. * Unable/dislike/unwilling to consume study foods or adhere to study protocol (e.g., not willing to drink a maximum 9 units of alcohol a week or consume animal products). * Currently reported pregnant or lactating. * Unwilling or unable to consume non-halal or non-kosher products. * Estimated energy requirements of \<1,500 kcal/day or \>3,000 kcal/day. * Unexplained or unintentional weight loss in the past six months.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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King's College London
RECRUITINGLondon, SE1 9NH, United Kingdom
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