Can cannabis calm a sleep-deprived, anxious brain? new study aims to find out.

NCT ID NCT07656350

Recruiting now Knowledge-focused Sponsor: King's College London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how THC and CBD, two compounds found in cannabis, affect the body's stress response in people who are sleep-deprived and have higher-than-average anxiety. Sixty healthy volunteers will take either THC, CBD, both, or a placebo after a night of restricted sleep. Researchers will measure skin conductance to see how their nervous system reacts to mild electric shocks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: THC and CBD oils
What this could lead to: If successful, this could help explain how cannabis-based products affect the body's stress response after poor sleep, pointing toward future treatments for anxiety or sleep disorders.
What could go wrong: This is a small, early-stage study in healthy volunteers, not patients. It is designed to measure physiological changes, not to test a treatment. Results may not apply to people with clinical anxiety or sleep conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anxiety disorder cannabis dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEER

Contacts and locations

Locations

The Centre for Mental Health Research and Innovation
RECRUITING

London, London, SE5 8BB, United Kingdom

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