HEALTHY VOLUNTEER

This study tests three new HIV vaccines in healthy adults aged 18-49 to see if they are safe and trigger an immune response. Two vaccines are given as nasal sprays, followed by a booster shot. The trial also monitors household and intimate contacts to check if the vaccine viruses…

This study is the first time REGN20423 is being tested in humans. It will enroll 144 adults, first healthy volunteers and then people with atopic dermatitis (eczema). The goal is to check safety, side effects, how the drug moves through the body, and whether it helps eczema sympt…

This early-stage trial tests a new drug called SIF001, a monoclonal antibody designed to treat epilepsy. Researchers are giving the drug to healthy volunteers and people with epilepsy to check its safety, how the body processes it, and what side effects may occur. The study uses …

This early-stage study tests a new medicine (NNC9733-0001) to see if it is safe and tolerable in healthy volunteers and people with type 2 diabetes. Participants receive either the study drug or a placebo as a single injection. The goal is to check for side effects and how the dr…

This study aims to refine a non-invasive hearing test called electrocochleography (EcoG) to better detect hidden hearing loss — a condition where standard hearing tests appear normal but auditory nerve fibers are damaged. Researchers will test 220 healthy volunteers aged 18-55 to…

This study looks at how a one-time dose of two F/TAF tablets (a medicine used to prevent HIV) works in healthy adults. Researchers want to see how much of the drug gets inside cells over 14 days. 24 healthy volunteers will take the pills and have their blood tested. The goal is t…

This study tests whether urolithin A, a natural supplement, can improve how the body releases insulin and controls blood sugar in healthy adults aged 55 and older with a BMI of 27 or higher. Over 8 weeks, 180 participants will take either urolithin A or a placebo daily. Researche…

This early-stage study is testing a new drug called ABBV-295 in 24 healthy Japanese adults who are overweight or obese. The main goal is to check the drug's safety and how the body processes it. Participants receive injections of the drug or a placebo, and researchers monitor for…

This study looks at whether adding a foam pad to a standard lumbar belt makes it more comfortable and improves back support. Fifteen healthy volunteers will wear the belt with and without the pad and rate their comfort. The goal is to see if a simple change can help people with l…

This study tests whether gentle electrical stimulation to the brain during a short nap can improve the quality of sleep and reduce mental tiredness. Twenty-five adults with non-restorative sleep will take two naps while wearing a special cap that records brain activity and delive…

This study is testing the safety of Niagen Plus, an injectable form of vitamin B3, in 40 healthy adults who feel tired. Participants will receive injections under the skin or into muscle over 100 days. Researchers will monitor side effects and measure changes in NAD+ levels, fati…

This early-stage study tests a new tablet called UA026 to see if it is safe and how the body processes it. It involves 124 people, including healthy volunteers and those with moderate to severe plaque psoriasis. The study is split into four parts to check different doses and the …

This study uses brain scans (fMRI) to see how blood flow changes in the brain when healthy adults do tasks involving vision, recognition, and memory. Researchers aim to understand normal brain function. Participants must be 18–65, healthy, and fluent in English.

This early-phase study will enroll 60 healthy volunteers to compare how the drug risankizumab behaves in the body when given as a shot under the skin versus through an IV. The main goals are to measure side effects and drug levels in the blood. No treatment or health benefit is e…

This study aims to collect normal test results from 500 healthy volunteers aged 5 to 80 to establish standard values for hearing and balance tests. Participants will undergo various hearing and balance assessments during one or two visits to the NIH Clinical Center. The informati…

This study is testing whether psilocybin, the active ingredient in magic mushrooms, is safe and tolerable for healthy adults aged 65 to 85. Researchers will monitor side effects and how the drug moves through the body. The goal is to gather safety data, not to treat any disease.

This study aims to improve magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques to better see and measure brain chemicals. Researchers will scan 300 healthy adults aged 18 to 65 to test and refine these imaging methods. The goal is to develop more accurate tools for…

This study tests four different HIV drug regimens in 120 healthy volunteers to see how they affect metabolism and weight. Participants take one of the drugs or a combination for four weeks, with blood tests, body scans, and optional fat biopsies. The goal is to understand why som…

This study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect medical data, blood, saliva, and tissue samples from people with these conditions, their relatives, and healthy volunteers. The goal is to better understan…

This study looks at how genetic immune system problems might lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from 700 people, including those with immune defects, healthy adults with gum disease, and healthy adults witho…

This study tests a drug called adimanebart in healthy adults to see how much of it gets into the bloodstream and how body weight affects that process. Participants receive a single dose either by IV or as an injection under the skin. Researchers will measure drug levels over time…

This early-phase trial tests the safety and tolerability of a new drug called HSK56630 in 40 healthy adults. Participants receive a single dose of the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. No therapeutic benefit is ex…

This early-stage trial is testing a single dose of bretisilocin in 26 healthy adults from Japanese, Han Chinese, and Non-Asian backgrounds. Researchers are checking for side effects and how the drug moves through the body. The goal is to gather basic safety information before tes…

This study aims to improve MRI technology for imaging the brain. Researchers will test new scanning methods on 1,100 healthy adults aged 18 and older. Participants will have yearly MRI scans and may perform simple tasks like listening to sounds or tapping fingers. The goal is to …

This study collects blood, urine, stool, and other samples from up to 150 healthy volunteers aged 18 to 85. Researchers will use these samples to compare with samples from patients who have too many eosinophils (a type of white blood cell), which can cause disease. The goal is to…

This early-stage study tests a single dose of ABBV-547 in healthy adults to check its safety, how the body processes it, and any side effects. About 121 participants in the US and Japan will receive either the drug or a placebo. The study has two parts with different dosing group…

This study looks at how THC and CBD, two compounds found in cannabis, affect the body's stress response in people who are sleep-deprived and have higher-than-average anxiety. Sixty healthy volunteers will take either THC, CBD, both, or a placebo after a night of restricted sleep.…

This study looks at how ketamine affects the brain in people with major depression and healthy volunteers. Researchers use brain scans, blood tests, and other measures to understand why a single dose works quickly but briefly. The goal is to find biomarkers that could lead to bet…

This study is recruiting up to 2,000 healthy adults aged 18-70 to create a pool of volunteers for future NIMH research. Participants complete online surveys, an in-person visit with medical and mental health checks, and optional brain scans. Their de-identified data will be share…

This study looks at two ways of giving a standard liquid meal to measure how the body handles sugar. One method gives everyone the same number of calories, while the other adjusts the calories based on a person's size. Researchers want to find out which method gives more consiste…

This study collects white blood cells from healthy volunteers to help researchers develop new immune-based cancer treatments. Participants undergo a 4-6 hour procedure called leukapheresis, where a machine separates white cells from the rest of the blood. Donors must be 18 or old…

This study looks at how a gene called ZIP8 influences alcohol drinking and its effects on the brain. Healthy volunteers aged 21 to 60 of European ancestry will receive alcohol through an IV and can choose how much to take. Brain scans and questionnaires will help researchers unde…

This study aims to find out if people who get calcium oxalate kidney stones produce more oxalate in their bodies than healthy people. Researchers will compare 80 adults—some with a history of stones and some without—after they eat a special low-oxalate diet and take small amounts…

This early-stage study is testing a new inhaled medicine called AN01 in 24 healthy adults. The goal is to check if it is safe and how the body processes it. This study does not aim to treat any disease; it is a first step to see if the drug is safe enough to test in people with C…

This early-stage study is testing a new drug called ABBV-1451 in healthy adults to see how safe it is and how the body processes it. About 90 volunteers will receive a single dose, and researchers will monitor for side effects and measure drug levels in the blood. The study also …

This study aims to find new markers in the blood that appear during non-allergic drug infusion reactions. Healthy adults will receive the antibiotic vancomycin and have blood samples taken to measure drug levels and other substances. The goal is to better understand and predict t…

This early-stage trial tests how a new form of oxycodone (PF614) combined with nafamostat behaves in the body. Fifty-four healthy adults will receive single doses to measure drug levels and safety. The goal is to see if this combination can reduce misuse potential while still pro…

This early-stage trial is testing a new drug, TL-003, for the first time in humans. The main goal is to check its safety and how the body processes it in 48 healthy adults, with a small group of people who have ulcerative colitis also being studied. Researchers will monitor for s…

This early-stage study is testing an experimental drug called emraclidine in 40 healthy adults aged 65 and older. Researchers want to see how the drug moves through the body and whether it causes any side effects. Participants will receive either emraclidine or a placebo pill. Th…

This study aims to understand why the protection from vaccines like those for COVID-19 fades over time. Researchers will follow 1,200 healthy adults for one year, collecting blood samples and health updates after they receive a vaccine or booster in their community. The goal is t…

This early-phase study is testing the safety of a new drug called BIIB142 in 78 healthy adults. Participants receive either the drug or a placebo, in single or multiple doses, to see how the body handles it and whether it causes any side effects. The study is split into two parts…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This Phase 1 study tests how two oral drugs, ABBV-722 and upadacitinib, affect each other in the body. Thirty-two healthy adults will take multiple doses to measure drug levels and check for side effects. The goal is to understand safety and drug interactions, not to treat any di…

This Phase 1 trial is testing the safety of a new drug called TRX-100 in 24 healthy adults aged 18 to 65. Participants will receive either TRX-100 or a placebo, and researchers will monitor side effects and how the drug moves through the body. This is an early-stage study with no…

This early-phase trial tests the safety of a single dose of HB2198, an experimental antibody that binds to two immune cell targets (CD19 and CD20). About 32 healthy adults will receive either the drug or a placebo and be monitored for about two months. The goal is to see if the d…

This study explores how combining mental movement practice (motor imagery) with tendon vibration affects brain activity. Thirty-three healthy adults will try three different timing combinations of vibration and imagery. Researchers will measure brain responses using magnetic stim…

This study tests whether a special drink containing ketones can change how healthy people breathe, especially during sleep. Twenty volunteers will try the drink and a placebo on separate visits. The goal is to see if ketones might one day help with breathing problems like sleep a…

This study is looking at 60 female rugby and basketball players in Saudi Arabia to understand how their physical fitness (like muscle strength and oxygen use) and mental traits (like confidence and resilience) relate to their risk of getting injured. The goal is to find ways to p…

This study looks at how three common medicines—fluconazole, itraconazole, and carbamazepine—change the way the body processes a new experimental drug called ASP3082. ASP3082 is being developed for cancers with a specific KRAS mutation. The trial involves 54 healthy adults split i…

This study looks at how type 1 diabetes affects the nerves that control the heart in children. Researchers will measure heart rate variability in 100 children with diabetes and compare them to healthy kids of the same age and sex. The goal is to find early signs of cardiac dysaut…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning earlier than standard scans. About 100 people with different solid tumors will give blood samples after treatment. The goal is to see if early detection can lead to better treatm…

This early-phase study is testing a drug called NX-5948 in 18 healthy adults to see how well a tablet form works compared to a capsule. It also looks at whether food or a common heartburn drug (esomeprazole) changes how the body absorbs NX-5948. The goal is to gather information …

This early-stage study tests the safety of a new drug called BIIB145, designed to help people with multiple sclerosis (MS). Researchers will give the drug or a placebo to 104 healthy adults in three parts, checking for side effects and how the body processes it. The goal is to se…

This early-phase study looks at whether reducing high insulin levels (common in type 1 diabetes) with an SGLT2 inhibitor can improve heart and blood sugar health. Researchers will compare people with type 1 diabetes, those with a mild genetic diabetes (GCK-MODY), and healthy volu…

This early-stage study tests a new antibiotic combination (ceftibuten-ledaborbactam) in 46 healthy adults aged 18-55. The goal is to check safety and how the drug moves through the body, not to treat any disease. Participants will stay at a clinic for several days and have follow…

This early-stage trial is testing a new drug, PN-881, in 142 healthy adults to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo as a single dose or multiple doses. The study is not designed to treat any disease but to gather …

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect bone issues like cancer, infection, or arthritis. About 200 adults will receive a tiny amount of radioactive tracer and be scanned on a high-sensitivity machine. The go…

This early-stage study by Pfizer will give atirmociclib to 72 healthy adults to see how the drug moves through the body at different doses after a meal. Participants will receive four single doses in a random order, with blood samples taken to measure drug levels. The goal is to …

This early-phase trial is testing a new drug called MT-201 in 72 healthy adults aged 19 to 55. The main goal is to see if the drug is safe and how the body handles it. Participants will receive either MT-201 or a placebo, and researchers will monitor for side effects and changes …

This early-stage study is testing a new drug called ABBV-1042 in 48 healthy adults to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo and be monitored for side effects, vital signs, and lab changes. This study does not aim t…

This study uses a radioactive tracer called [18F]NOS to measure lung inflammation in 100 people who vape nicotine, vape cannabis, smoke cigarettes, or don't smoke at all. Participants get one PET/CT scan to compare inflammation levels between groups. The goal is to better underst…