HEALTHY VOLUNTEER

This study tests whether three new HIV vaccines are safe for healthy adults aged 18 to 49. Two vaccines are given as nasal sprays and one as a booster shot. Researchers will also check if the vaccines help the body fight HIV and if the viruses used in the vaccines can spread to o…

This early-stage study tests a new medicine (NNC9733-0001) to see if it is safe and can lower high blood sugar in people with type 2 diabetes. About 72 participants — both healthy volunteers and people with diabetes — will receive either the study drug or a placebo as a single in…

This study looks at how a one-time dose of two F/TAF tablets (a common HIV prevention pill) works in the body over 14 days. It involves 24 healthy volunteers to measure drug levels inside cells. The goal is to see if a higher single dose could be a simpler way to prevent HIV.

This early-stage study tests whether a new tablet called UA026 is safe and how it works in the body. It involves 124 people, including healthy volunteers and those with moderate to severe plaque psoriasis. The goal is to find the right dose and check for side effects, not yet to …

This study looks at whether adding a foam pad to a standard lumbar belt makes it more comfortable for healthy adults and people with low back pain. Researchers will measure comfort on a scale from 0 to 10. The goal is to see if a small change can improve how the belt feels during…

This study tests the safety of Niagen Plus, an injectable form of vitamin B3, in 40 generally healthy adults with fatigue. Participants receive injections under the skin or into muscle over 100 days, and researchers monitor side effects, NAD+ levels, and changes in fatigue, sleep…

This study is testing a new drug, MD-18, given as an injection under the skin, to see if it is safe and tolerable for healthy adults who are overweight or obese. The trial involves 54 participants and will monitor side effects, vital signs, and lab results. The goal is to gather …

This study tests whether a gentle electrical current applied to the scalp during a short nap can boost brain activity linked to deep sleep and reduce mental fatigue. About 25 adults with non-restorative sleep will take two naps in the lab while wearing a special cap to measure br…

This early-stage study tests a new drug called ABBV-295 in 24 healthy Japanese adults who are overweight or obese. The main goal is to check the drug's safety and how the body processes it. Participants receive injections, and researchers monitor for side effects. This is a first…

This early-stage study looks at whether taking ketone supplements can affect breathing during sleep. Researchers will give 20 healthy adults either a ketone drink or a placebo and measure their breathing response to carbon dioxide. The goal is to gather basic information, not to …

This study looks at how type 1 diabetes affects the automatic nerves that control heart rate and breathing in children. Researchers will compare 100 children with and without diabetes using simple heart recordings. The goal is to detect early signs of nerve damage, not to test a …

This study looks at two ways of giving a test meal to healthy adults: one where everyone gets the same number of calories, and one where the calories are adjusted based on a person's body size. Researchers want to find out which method leads to more consistent blood sugar results…

This study collects blood, urine, stool, and other samples from up to 150 healthy volunteers aged 18 to 85. Researchers will use these samples to compare with those from patients who have too many eosinophils, a type of white blood cell that can cause disease. The goal is to bett…

This study looks at how a new drug, NX-5948, is absorbed in the body when taken as a tablet versus a capsule, and whether food or an acid-reducing drug changes that. It involves 18 healthy adults aged 19-55. The goal is to find the best way to take the medicine, not to treat any …

This study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect medical information, blood, saliva, and tissue samples from people with these conditions, their relatives, and healthy volunteers. The goal is to better un…

This early-stage study tests whether the experimental drug MT-201 is safe and how the body processes it. It involves 72 healthy adults aged 19 to 55 who will receive either the drug or a placebo. The goal is to gather safety information, not to treat any disease.

This early-stage study tests the safety of a new drug called HB2198 in 32 healthy adults. Participants receive a single dose and are monitored for about two months. The goal is to see if the drug is safe and how the body processes it, not to treat any disease.

This early-stage study is testing a new inhaled medicine called AN01 in 24 healthy adults to see if it is safe and how the body processes it. AN01 is being developed as a possible treatment for COPD, a lung disease that makes breathing hard. The study does not involve people with…

This study is testing a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect bone issues like cancer, infection, and arthritis. Researchers will enroll 200 adults to see if the new technique still produces clear images. Participants get a r…

This study tests a new drug, ENX-205, in 60 healthy adults to see if it is safe and how the body processes it. Participants receive a single dose and are monitored for side effects. Some also get a brain scan to see where the drug goes. This is early research with no direct healt…

This early-stage study tests a new drug called ABBV-1042 in 48 healthy adults to see if it is safe and how the body processes it. Participants receive either the drug or a placebo, and researchers monitor for side effects and measure drug levels in the blood. This study does not …

This study aims to understand why the protection from vaccines, like those for COVID-19, decreases over time. Healthy adults aged 18 and older who are scheduled for a new vaccine or booster shot can join. Participants will give blood samples and health updates over one year to he…

This early-phase study looks at whether reducing high insulin levels with an SGLT2 inhibitor can improve heart and blood sugar health in people with type 1 diabetes. Researchers will compare results with people who have a mild genetic form of diabetes (GCK-MODY) and healthy volun…

This study uses a radioactive tracer and PET/CT scan to measure lung inflammation in people who vape nicotine or cannabis, compared to cigarette smokers and non-smokers. Researchers aim to understand how different smoking and vaping habits affect lung health. The study involves 1…

This study looks at how problems with the immune system can lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from people with genetic immune defects, healthy people with gum disease, and healthy people without gum disease…

This study collects white blood cells from healthy volunteers to help researchers develop new cancer therapies that use a person's own immune system to fight tumors. Participants must be 18 or older and in good health. The donation process takes 4-6 hours and can be repeated ever…

This study aims to develop better MRI methods for looking at the brain's structure and activity. Healthy adults aged 18 and older will have yearly MRI scans, sometimes while doing simple tasks like listening or tapping fingers. The goal is to improve imaging technology, not to tr…

This early-stage study is testing a new drug, ABBV-547, in healthy adults to see if it is safe and how the body handles it. About 87 participants in the US and Japan will receive a single dose of the drug or a placebo. The study will monitor side effects and measure drug levels i…

This early-stage study tests a new antibiotic combination (ceftibuten-ledaborbactam etzadroxil) in about 46 healthy adults aged 18-55. The goal is to check safety and how the drug moves through the body, not to treat any disease. Results will help decide if further studies are po…

This study uses brain scans (fMRI) to watch blood flow changes in the brain while healthy adults do tasks involving seeing, recognizing, and remembering objects. Researchers aim to understand how the brain processes visual information and memory. Participants must be healthy, age…

This study aims to make MRI and MRS scans better at measuring chemicals in the brain and muscles. Researchers will test new imaging methods in 300 healthy adults aged 18 to 65. Participants will have a medical checkup and one or two scanning sessions. The goal is to improve the t…

This study looks at how ketamine works in the brain to treat depression quickly. Researchers will use brain scans and other tests to understand why a single dose can lift mood within hours. About 150 adults with major depression and healthy volunteers will take part, receiving ke…

This early-stage study is testing a new drug, TL-003, to see if it is safe and how the body processes it. The study first involves healthy adults, then a small group of people with ulcerative colitis. The main goal is to check for side effects and measure drug levels in the blood…

This study is testing whether psilocybin, the active ingredient in magic mushrooms, is safe and tolerable for healthy adults aged 65 to 85. About 40 participants will receive the drug and be monitored for side effects. The goal is to gather safety data, not to treat any disease.

This early-stage study is testing the safety of a new drug called BIIB142 in healthy adults. Researchers want to see how the body handles the drug and what side effects may occur. The study involves giving single or multiple doses to different groups and comparing them to a place…

This study tests whether urolithin A, a natural supplement, can improve how the body controls blood sugar in healthy adults aged 55 and older with a higher body mass index. Researchers will measure insulin and other hormone levels after taking the supplement for 4 and 8 weeks. Th…

This study aims to collect normal hearing and balance test results from 500 healthy volunteers aged 5 to 80. Participants will undergo various hearing and balance tests during a single visit to the NIH Clinical Center. The data will help doctors know what test results are normal …

This study looks at how a gene called ZIP8 might affect why some people are more likely to develop alcohol use disorder. Researchers will give alcohol through an IV to healthy volunteers and measure how much they choose to drink. They will also scan participants' brains to see ho…

This early-stage study tests how two oral drugs, ABBV-722 and upadacitinib, affect each other in the body. About 32 healthy adults will take both drugs and have blood samples taken to measure drug levels. The main goal is to understand safety and how the drugs are processed, not …

This early-stage study tests how the body processes different doses of the experimental drug atirmociclib when taken with food. It involves 72 healthy adults aged 18-65. The goal is to measure drug levels in the blood and check safety, not to treat any disease.

This study tests whether a new tablet form of the drug omaveloxolone (BIIB141) that dissolves in liquid works the same in the body as the current capsule form. The study involves 70 healthy adults who will take both forms at different times. The goal is to see if the liquid table…

This study looks at why some HIV drugs cause weight gain. Healthy volunteers aged 18 to 55 will take one of four HIV medications for 4 weeks. Researchers will measure changes in blood, fat tissue, and body composition to understand the early metabolic effects. The goal is to find…

This early-stage study tests a new tablet called TRX-100 in 24 healthy adults aged 18 to 65. The goal is to check if the drug is safe, how the body processes it, and whether food changes its effects. Participants receive either TRX-100 or a placebo, and no direct treatment benefi…

This study aims to find out what physical and mental factors make female rugby and basketball players in Saudi Arabia more likely to get injured. Researchers will measure muscle strength, fitness levels, and psychological traits like confidence and resilience in 60 athletes aged …

This early-stage study is testing a new drug, PN-881, in 142 healthy adults to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo. The goal is to gather safety information, not to treat any disease.

This early-stage study tests the safety and tolerability of emraclidine, an experimental oral drug, in 32 healthy adults aged 65 and older. Participants receive either the drug or a placebo to see how the drug moves through the body and whether it causes side effects. This study …

This study observes 200 people already taking psychedelics in other trials to understand how these drugs change brain processing. Researchers use brain scans, computer tasks, and interviews to measure shifts in learning, perception, and electrical activity. The goal is to predict…

This study looks at how a new drug called ABBV-722 changes the way birth control pills work in the body. It involves 16 healthy volunteers who will take both the drug and the pill. The goal is to see if the drug affects the levels of the pill's hormones, which could change how we…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning sooner than standard scans. Researchers will follow 100 people with various solid tumors to see if early detection leads to better treatment options. The goal is to improve how w…

This study aims to recruit up to 2,000 healthy adults aged 18-70 to serve as a reference group for other mental health studies at the NIH. Participants complete online surveys, an in-person checkup, and optional brain scans. Their de-identified data will be shared broadly to help…

This study looks at how three common medicines (fluconazole, itraconazole, and carbamazepine) change the way the body processes an experimental cancer drug called ASP3082. About 54 healthy adults will take ASP3082 alone and with each of the other drugs to measure differences in d…

This study explores how combining mental imagery of movement with tendon vibration can boost brain signals related to movement. Researchers will test three different timing methods in 33 healthy adults aged 18-50. The goal is to find the best approach to improve rehabilitation fo…

This early-stage study tests the safety of a new drug called BIIB145, which is being developed for multiple sclerosis (MS). About 104 healthy adults will receive either the drug or a placebo to see how the body handles it and if any side effects occur. The study has three parts, …