HEALTHY VOLUNTEER

This early-stage study is testing whether three new experimental HIV vaccines are safe for people. Healthy volunteers will receive two nasal spray vaccines followed by a booster shot, while researchers monitor for side effects and check if the vaccine viruses can spread to househ…

This study aims to understand how ketamine, a drug with rapid antidepressant effects, works in the brain. Researchers are enrolling 150 adults with major depression and healthy volunteers to receive repeated ketamine infusions while undergoing brain scans and other tests. The goa…

This early-stage study is testing the safety of a new injectable drug called MD-18 in healthy adults who are overweight or have obesity. Over four weeks, 54 participants will receive either the drug or a placebo injection to see how their bodies react. The main goal is to check f…

This early-stage study is testing the safety and body's response to a new injectable medicine called NNC9733-0001 for type 2 diabetes. It involves 72 participants, including both healthy volunteers and people with type 2 diabetes, who receive either the medicine or a placebo inje…

This study is testing if using an add-on pill to lower the amount of insulin needed can improve heart and blood vessel health in people with type 1 diabetes. Researchers will compare people with type 1 diabetes to people with a milder genetic form of diabetes and healthy voluntee…

This is the first study in people for a new pill called UA026, designed to treat plaque psoriasis by blocking a protein that causes inflammation. The main goal is to check the safety, side effects, and how the drug moves through the body in healthy volunteers and people with mode…

This study is testing a new type of PET scan that uses much less radiation than current methods to detect bone problems. Researchers want to see if they can reduce radiation exposure by 10 to 100 times while still getting clear images of bone conditions like cancer, arthritis, an…

This study is testing whether a natural supplement called Urolithin A can help the body manage blood sugar better as people age. Researchers will enroll 180 healthy adults aged 55 and older to take either the supplement or a placebo for 8 weeks. They'll measure how the body respo…

This study is testing how a double dose of a common HIV prevention pill (Descovy) moves through the body of healthy volunteers over 14 days. The goal is to understand if taking the pill less often could still provide protection against HIV. This early-phase research involves 24 p…

This study is testing the safety of a new injectable supplement called Niagen® Plus in healthy adults who experience fatigue. Over 100 days, 40 participants will receive injections to see how well the body tolerates them and if they affect energy-related markers in the blood. The…

This study is testing whether a gentle, non-invasive form of electrical brain stimulation, applied while a person naps, can improve the quality of that sleep. Researchers want to see if this can boost specific brain waves linked to deep sleep and help people feel less mentally ti…

This study is testing whether adding a foam pad to a standard lower back support belt makes it more comfortable to wear. Researchers are enrolling 15 healthy volunteers to try the belt with and without the extra pad. They will rate their comfort and use special scans to see if th…

This study collects immune cells from healthy volunteers to help researchers develop new cancer treatments. Participants undergo a 4-6 hour blood filtering process to donate white blood cells. These donated cells are used in the lab to help grow cancer patients' own immune cells,…

This is the first time researchers are testing a new oral drug called ABBV-1042 in people. The study aims to check if the drug is safe and how the body processes it in 48 healthy adult volunteers. Participants will receive either the drug or a placebo, and doctors will monitor th…

This study aims to understand how genetic immune system problems affect oral health, particularly gum disease. Researchers will compare people with immune disorders, those with severe gum disease, and healthy volunteers by collecting samples like saliva, plaque, and blood. The go…

This early-stage study aims to understand how three common medications (fluconazole, itraconazole, and carbamazepine) affect the body's processing of a new experimental drug called ASP3082. ASP3082 is being developed to target a specific genetic mutation found in some solid tumor…

This study aims to measure and compare lung inflammation in different groups of people using a special imaging scan. Researchers will use an experimental radioactive tracer during a PET/CT scan to see if there are differences in lung inflammation between e-cigarette users, tradit…

This is the first study to test a new experimental drug called BIIB142 in people. Researchers want to see if it's safe and how the body handles it. The study involves 78 healthy adults who will receive either the drug or a placebo. The main goal is to find the highest dose that d…

This study aims to find the best way to conduct a standard meal test used in nutrition research. Healthy volunteers will eat two different test meals—one a fixed size for everyone and one adjusted to their body's needs—while researchers measure their blood sugar response. The goa…

This study collects blood, tissue, and fluid samples from healthy volunteers to compare with samples from people who have high levels of certain white blood cells (eosinophils) that can cause disease. Up to 50 paid volunteers aged 18-65 will participate over about 10 years. The s…

This early-stage study aims to check the safety and measure how the body processes a new combination antibiotic drug. Researchers will enroll 46 healthy adults to receive the medication and monitor them for side effects. The study focuses on understanding how the drug moves throu…

This study aims to understand why the immune protection from vaccines, like those for COVID-19, decreases over time. Researchers will follow healthy adults who are scheduled to get a new vaccine or a booster shot. Participants will provide blood samples over one year so scientist…

This is the first study testing the experimental drug MT-201 in humans. Researchers will give single and multiple doses to 72 healthy volunteers to check for side effects and see how the body processes the drug. The main goal is to determine if MT-201 is safe enough for further t…

This study aims to see if a new liquid tablet form of the drug omaveloxolone (SKYCLARYS®) is processed by the body the same way as the currently available capsules. It involves about 70 healthy adults who will take both forms of the drug in a specific order, with a break in betwe…

This study is testing a blood test that looks for tiny pieces of tumor DNA to see if it can detect cancer recurrence earlier than standard scans. It aims to enroll 100 adults, including people with various solid tumors and healthy volunteers. The goal is to gather information tha…

This early-stage study aims to understand how the body absorbs and processes different amounts of an experimental drug called atirmociclib when taken after a meal. It will involve 72 healthy adult volunteers who will take single oral doses of the drug. Researchers will measure th…

This is a very early study to check the safety of a new drug called BIIB145, which is being developed for multiple sclerosis (MS). Researchers will give the drug to 104 healthy volunteers to see what side effects occur and how the body absorbs and processes it. The study will tes…

This study aims to understand why some people might be more vulnerable to developing alcohol problems by looking at a specific gene called ZIP8. Healthy volunteers who drink alcohol but do not have an alcohol use disorder will receive controlled alcohol infusions and have their b…

This early-stage study aims to see if two different versions of a migraine prevention drug are absorbed and processed the same way by the body. It involves 64 healthy adult volunteers who will each try both drug versions. The main goal is to gather data on how the body handles th…

This is the first study to test the experimental drug JUV-161 in people. It aims to check the safety, side effects, and how the drug moves through the body in 40 healthy adult volunteers. The data collected will help plan future studies in patients with muscle-wasting diseases li…

This study aims to improve a special type of MRI scan that can measure chemicals in the brain and muscles. Researchers will test and refine these scanning techniques on 300 healthy volunteers over ten years. The goal is to create better tools for future research into psychiatric …

This study aims to develop better brain scanning technology to understand how a normal, healthy brain works. Researchers are recruiting over 1,000 healthy adults to have detailed MRI scans while performing simple tasks. The information will help create clearer pictures of the bra…

This early-stage study aims to understand how a new drug, NX-5948, is absorbed by the body when taken as a tablet versus a capsule. Researchers will also check if eating food or taking a common heartburn medicine changes how the drug works. The study involves 18 healthy adult vol…

This early-stage study aims to test the safety of a new oral drug called ENX-205 in healthy volunteers. Researchers will give increasing doses to 60 participants and use brain scans to see how the drug interacts with its target. The main goal is to understand how the body process…

This is an early, first-in-human study to check the safety of a new drug called D-2570. It will involve 36 healthy volunteers who will receive either the drug or a placebo (inactive pill) at different dose levels. The main goal is to see how safe the drug is and how the body abso…

This study aims to understand how type 1 diabetes affects the nervous system's control of the heart in children. Researchers will compare 24-hour heart rate patterns in 100 children with diabetes against healthy children of the same age and sex. The goal is to see if longer diabe…

This early-stage study aims to understand how the body absorbs and processes a new drug called ABBV-8736. It will compare giving the drug as a simple shot under the skin versus through an IV drip. The study involves 40 healthy adult volunteers to check how the drug moves through …

This National Institutes of Health study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect health information, saliva, blood, and tissue samples from people with these conditions (like Sjogren's syndrome), their fami…

This study aims to understand why some HIV medications cause weight gain, a side effect that can lead to serious health problems. Researchers will measure how two common drugs affect the body's energy use in 120 healthy volunteers. Participants will take each drug for a short per…

This is a very early study to see how a new drug called emraclidine moves through the body and how safe it is for healthy older adults to take. Researchers will give the drug to a small group of 32 elderly volunteers and closely monitor them for any side effects. The main goal is…

This study aims to understand how different parts of the brain work when people perform everyday mental tasks. Researchers will use brain scanning technology (fMRI, MEG, EEG) to measure blood flow and activity in the brains of healthy volunteers as they do tasks involving vision,…

This study aims to collect normal results for various hearing and balance tests from healthy people. Researchers need to know what 'normal' looks like so they can better identify when a test result shows a problem. The study involves one or two visits for tests and is open to hea…

This early-stage study aims to understand how a new injectable drug called ABBV-295 interacts with common birth control pills. It will involve 20 healthy adult women who have overweight or obesity. The main goal is to check for safety issues and see how the body processes these d…

This is the first study testing a new drug called ABBV-547 in people. Researchers will give single doses to 87 healthy adults to check for side effects and see how the body processes the drug. The main goal is to understand the drug's safety before testing it in people with medic…

This is the first study in humans for a new drug called PN-881. It aims to check if the drug is safe and how the body handles it in healthy adults. Researchers will give different doses and forms of the drug to see how it behaves and what side effects might occur.

This Yale University study aims to understand if a specific virtual reality program can create experiences similar to taking psychedelic drugs. Researchers will enroll 15 healthy volunteers to compare the virtual reality experience against known psychedelic effects using question…

This study aims to understand what makes female athletes in Saudi Arabia more likely to get injured while playing sports like rugby and basketball. Researchers will measure 30 athletes' physical fitness and mental resilience to see which factors predict injury risk. The goal is t…