HEALTHY VOLUNTEER

This phase 1 trial tests whether sirolimus (rapamycin), an FDA-approved medication, can improve blood flow and energy use in the brains of women aged 45 to 65 who carry the ApoE4 gene — a gene that raises the risk of developing Alzheimer's disease. Participants are randomly assig…

This pilot study in Nepal is testing whether suvarnaprashana — a traditional Ayurvedic preparation made with purified gold, honey, and ghee — is safe and may strengthen the immune system in healthy children aged 2 to 5 years. Over 8 weeks, researchers will monitor for side effect…

This early-stage trial tests a new fixed-dose combination pill called Viaca, which contains sildenafil and cabergoline, for erectile dysfunction. The study enrolls 30 healthy adult male volunteers to compare the safety, tolerability, and drug levels of the combination against eac…

This study will compare two treatments—low-level laser therapy and hyaluronic acid gel—to see which helps children's gums heal better after removing a badly decayed first permanent molar. Thirty-six children aged 6 to 10 will receive one of the treatments right after extraction. …

This study will enroll 800 healthy adults to explore why some people gain weight easily while others do not. Researchers will collect data from blood, urine, body scans, glucose monitors, and eating tests over two years. They will use machine learning to find patterns that predic…

This natural history study looks at how life events during childhood might affect eating behaviors and weight gain in adults. Researchers will observe 110 healthy volunteers aged 18 to 60, measuring food intake, physical activity, blood sugar, and body fat. Participants will also…

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

This observational study aims to understand how healthy adults process and respond to visual images, particularly socially relevant ones like faces. Researchers will track eye movements and attention as participants view images on a screen. The study involves healthy volunteers a…

This study looks at brain activity in teenagers aged 10 to 17 with ADHD, OCD, or no diagnosis. Researchers will use EEG, MRI, and MEG to measure brain signals while participants do computer tasks. The goal is to understand how the brain controls thinking and behavior, which may h…

This early-stage study looks at how a new drug called ABBV-932 moves through the body when taken with another drug, itraconazole. Twenty healthy adults will take both drugs and have their blood levels measured. The goal is to check for side effects and see if itraconazole changes…

This early-stage trial will test the safety and how the body handles an inhaled antibody called TRL1068 in 14 healthy volunteers. Participants will receive either the drug or a placebo through a nebulizer. The study aims to gather initial safety data and does not target any speci…

This Phase 1 trial tests the safety and tolerability of a new drug called FB102 in 56 healthy volunteers. Participants receive either a single dose, multiple weekly doses, or a placebo. The study focuses on side effects and how the drug moves through the body, not on treating any…

This observational study will use brain scans (fMRI) and facial expression recordings to understand how emotions influence decision-making in everyday situations. 120 healthy adults aged 18-45 will perform tasks that mimic real-life choices while their brain activity and facial e…

This study is the first time REGN22044 is given to humans. It will enroll 64 healthy adults to check for side effects, measure drug levels in the blood, and see if the body makes antibodies against it. The goal is to gather safety and dosing information, not to treat any disease.

This first-in-human study tests whether hydrogen-oxygen ultrafine bubbles can be safely infused into the bloodstream of healthy adults. About 40 participants will receive two infusions one week apart, with doses increasing in later groups. The study only checks for side effects a…

This early-stage study looks at how two common drugs—itraconazole (an antifungal) and ticagrelor (a blood thinner)—change the way the body processes AL3818, a potential cancer treatment. Sixteen healthy adults aged 18 to 45 will take AL3818 alone and then with each other drug. Th…

This study looks at how five common tuberculosis drugs move into breast milk after a single dose. Sixty healthy breastfeeding women in Indonesia will each receive one drug, and researchers will measure drug levels in their blood and milk. The goal is to gather safety data so that…

This study will follow 120 female runners during ultra-endurance races (69-80 km) to see how their hearts and inflammation levels change. Researchers will use ultrasound scans before, during, and after the race, and link those changes to hormone levels like estrogen and testoster…

This study is gathering data from 150 healthy children aged 6-11 to improve the QbMobile digital test, which measures attention, impulsivity, and activity. The test is a 10-minute game-like task. The goal is to create better reference scores so doctors can more accurately identif…

This study looks at how two liquid forms of metformin are absorbed by the body compared to standard tablets. It involves 24 healthy adults aged 18 to 55. The goal is to gather information, not to treat any disease.

This study looks at how a new liquid version of metformin (a common diabetes medicine) is absorbed by the body compared to regular tablets. Twenty-four healthy adults will take both forms in a random order, with blood tests to measure drug levels. The goal is to see if the liquid…

This study tests if a liquid form of metformin (a common diabetes drug) works as well as the standard tablet. Healthy adults aged 18-55 will take both versions at different times, and researchers will measure drug levels in their blood. The goal is to see if the liquid is a good …

This study looks at how a new tablet called IN-M00002 behaves in the body of healthy adults aged 19 to 55. It also checks how food and other medicines (tegoprazan and naproxen) affect the drug. The goal is to gather safety and drug-level information, not to treat any disease.

This study will test a Turkish version of a questionnaire that measures how easy virtual reality systems are to use. Researchers will ask 54 healthy adults aged 18-50 to use a VR system and then fill out the 9-item questionnaire. The goal is to make sure the Turkish version is ac…