HEALTHY VOLUNTEER

This study tests a new PET heart scan that uses 10 to 100 times less radiation than current methods. It involves 200 adults with known or suspected heart artery disease. Participants get a tiny dose of a radioactive tracer and are scanned for up to 3 hours to see if the images ar…

This early-stage study in 9 healthy adults aims to understand how the experimental drug ABBV-932 is absorbed and processed by the body, including whether food affects its levels. Participants take the drug by mouth and provide blood samples to measure drug concentrations. The stu…

This study screens up to 10,000 people with blood disorders or healthy volunteers to see if they can safely join other NHLBI research studies at the NIH. Participants undergo tests like blood work and imaging. If eligible, they may be offered a spot in an active study; if not, th…

This early-stage study involves 8 healthy adult men to understand how the experimental drug mosliciguat is absorbed, broken down, and removed from the body. Participants receive the drug by inhalation, injection, and mouth over three periods. The goal is to measure drug levels an…

This study tests a tool called QbMobile that measures attention, impulsivity, and activity levels during a 10-minute test. It aims to see if the tool can provide accurate, objective data to help diagnose and manage ADHD, both in clinics and remotely. The study includes 700 people…

This early-phase study tests whether a special PET scan using a tracer called 18F-NOS can measure inflammation in the brains of people with Parkinson's disease. Eleven participants, including both Parkinson's patients and healthy volunteers, will receive the scan to compare brain…

This early-stage study tests the safety and how the body handles D-2570 tablets in 36 healthy adults. Participants receive either the drug or a placebo, and researchers monitor side effects and drug levels in the blood. The goal is to gather safety data, not to treat any disease.

This early-stage study looks at how a new drug called ABBV-295 interacts with common birth control pills in healthy women who are overweight or obese. The main goal is to check for side effects and measure drug levels in the body. About 20 women will take part to help researchers…

This early-stage study tests whether a new drug called ALN-F1202 is safe and tolerable in healthy adults. Researchers will also measure how the drug moves through the body and what side effects may occur. The study involves 56 participants and does not aim to treat any disease.

This study looks at how a common antifungal drug (itraconazole) changes the way ABBV-932 moves through the body. About 20 healthy adults will take both drugs and have their blood levels measured. The goal is to check safety and understand the drug interaction, not to treat any di…

This early-stage study tests JUV-161 for the first time in people. It aims to check safety and how the drug moves through the body in 72 healthy adults aged 18 to 60. Results will help plan future studies in patients with muscle diseases like myotonic dystrophy.

This early-stage study tests a single dose of the investigational drug ABBV-701 in about 100 healthy adults from Western and Asian backgrounds. The main goal is to check for side effects and measure how the drug moves through the body. Participants receive either the drug or a pl…

This study involves 40 healthy adults to see how the experimental drug ABBV-8736 moves through the body when given as a shot under the skin compared to an infusion into a vein. Researchers will measure drug levels, safety, and side effects. The goal is to find out if the under-th…

This study uses a special PET/CT scan to look at inflammation in the brains of people with Alzheimer's disease or mild cognitive impairment, compared to healthy volunteers. Researchers will test a new imaging tracer called [18F]NOS to see how it highlights inflammation. The goal …

This study looks at how healthy adults absorb and process three different ketone supplements (monoester, tri-ester, and salt). Researchers will measure levels of a key ketone body in the blood and check for any stomach discomfort or side effects. The goal is simply to gather info…