HEALTHY VOLUNTEER

This study tested whether a simple, non-invasive stomach ultrasound can accurately detect dangerous fluid levels in children before anesthesia. 92 healthy children aged 1-10 drank different amounts of clear liquid, then had their stomachs scanned. The goal was to see if the ultra…

This study tested a single injection of nirsevimab in over 8,000 healthy infants under 12 months to see if it could prevent hospitalizations from RSV, a common respiratory virus. Babies were randomly assigned to receive the shot or no intervention, and researchers tracked RSV-rel…

This study tested whether a daily tablet containing a special probiotic (LC-Plasma) could help healthy adults avoid upper respiratory infections like colds. Over 600 participants took either the probiotic or a placebo pill every day for 24 weeks. Researchers tracked how many peop…

This study tested whether a daily tablet containing a special probiotic (LC-Plasma) can boost the immune system and reduce symptoms of upper respiratory infections like the common cold in healthy adults. 241 participants took either the probiotic or a placebo for 4 weeks. Researc…

This study tested whether taking a carotenoid supplement (CaroRite™) can improve skin health and reduce visible signs of aging like wrinkles, dryness, and uneven tone. Eighty healthy women aged 40-55 took either the supplement or a placebo for a period of time. Researchers used s…

This study looked at how the experimental drug ESK-001 affects the heart's electrical activity in 52 healthy adults aged 18 to 55. Participants received ESK-001, a placebo, and moxifloxacin at different times to compare effects. The main goal was to see if ESK-001 causes any chan…

This study looked at how a new tablet form of the drug venetoclax is absorbed in the body. 72 healthy women took the new tablet and the current tablet to compare them. The study also checked if eating a high-fat meal changes how the new tablet works. This was a phase 1 study with…

This study looked at how taking icovamenib capsules with or without food changes the way the drug moves through the body. Sixty healthy adults took the drug under different conditions to measure absorption and processing. The results will help decide the best way to take icovamen…

This early-stage study tested a single dose of the experimental drug DR-01 in 32 healthy volunteers to see if it is safe and how the body processes it. Participants received either the drug or a placebo by injection under the skin. The study is complete and provides important saf…

This study looked at whether MT-8554, an experimental drug, changes the heart's electrical activity (QT interval) in 48 healthy adults aged 18 to 55. Participants received either a low dose, high dose, or a placebo. The goal was to check for heart rhythm risks, not to treat any d…

This study tested whether different versions of a CGRP receptor antagonist (a type of migraine medicine) are absorbed and processed by the body in the same way. It involved 64 healthy adults aged 18 and older who received a single dose of each formulation. The goal was to see if …

This study tested two different ways to give the same medicine (pegfilgrastim) to 180 healthy adults: one using an auto-injector and the other a pre-filled syringe. The goal was to see if the drug enters the body the same way with both methods and to check for any side effects. P…

This study tested a smaller, 6-lead ECG device placed on the chest against the standard 12-lead ECG in 24 healthy adults. The goal was to see if the quicker device gives accurate heart measurements. Results could help doctors get heart readings faster in emergency rooms or ambula…

This study tested a new drug called ABBV-142 in 73 healthy adults to see if it is safe and how the body handles it. Participants received a single dose, and researchers measured side effects and drug levels in the blood. The goal was to gather early safety information, not to tre…

This early-stage study tested a single dose of the experimental drug SAGE-718 in 22 healthy adults. Researchers used a ketamine challenge to see how the drug affects brain electrical activity, safety, and how the body processes it. The goal was to gather information, not to treat…

This study collected blood, skin, and mucosal samples from 304 healthy volunteers and patients with skin or systemic diseases. The samples were used to support basic science and clinical research at the NIH. No treatment was given; the goal was to gather materials for future stud…

This study tested a virtual reality program (DeepDream) to see if it can produce experiences similar to psychedelic drugs. Ten healthy volunteers used the VR and reported their feelings using standard questionnaires. The goal is to explore VR as a safe, drug-free tool for studyin…

This early-stage study tested multiple doses of MLS101 (a low-dose psilocybin) in 20 healthy volunteers aged 18 to 55. Researchers used brain scans (fMRI) to see how the drug affects brain activity and checked for side effects. The goal was to gather safety and brain-imaging data…

This study used MRI scans to measure how the brain moves inside the skull during gentle head motions, like turning your head. Researchers studied 90 healthy adults aged 18-65 to create a database of normal brain movement. The goal was to develop a new imaging method that could he…

This early-stage study tested the safety of a single dose of ARGX-109 in 40 healthy adults aged 18 to 65. Researchers also measured how the drug moves through the body and how it affects immune signals. No treatment was given for any disease; the goal was simply to gather initial…

This study looked at how a high-fat meal changes the way the drug ABBV-101 moves through the bodies of 17 healthy adults. Participants took ABBV-101 by mouth, and researchers measured drug levels in the blood and checked for side effects. The goal was to understand if food affect…

This study tested an experimental drug called EP395 in 40 healthy adults. Researchers used a safe, temporary lung inflammation model (inhaled endotoxin) to see how the drug affects immune markers and to check its safety. The goal was to gather early information, not to treat a di…

This study looked at how stress from the COVID-19 pandemic, like social distancing and lockdowns, affected people's mental health. Over 3,600 adults completed online surveys every two weeks for up to six months. The goal was to understand the link between pandemic-related stresso…

This study looked at how the body processes the drug omaveloxolone (SKYCLARYS®) when taken as a whole capsule versus sprinkled over low-fat yogurt. 52 healthy adults each took the drug both ways, with a 14-day break in between. The goal was to see if yogurt is a good alternative …

This study looked at how a drug being tested for Alzheimer's disease, called BIIB080, spreads through the brain and spinal cord. Five healthy adults received a tiny radioactive version of the drug along with a regular dose, then had PET scans to track it. The main goal was to mea…

This early-stage study tested the safety and how the body handles a new drug called ABBV-8736. Twenty-four healthy adults received either the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood, not to treat any disease.

This study looked at whether doing virtual reality exercises with other people (multi-player) is more motivating than doing them alone. It included 86 participants: healthy teens, children and adults with movement problems, and older adults with breathing conditions. The goal was…

This study tested three different devices (a pre-filled syringe, an autoinjector, and an on-body injector) to give the drug litifilimab under the skin. The goal was to see how the body processes the drug with each device. 404 healthy volunteers took part, and the study focused on…

This study looked at how the drug omaveloxolone (used for Friedreich's Ataxia) affects the way the body processes omeprazole, a common heartburn medication. Twenty-two healthy adults took both drugs in a specific order over 17 days. Researchers measured omeprazole levels in the b…

This early-stage study tested an experimental drug called SAGE-718 in 19 healthy adults to see how it affects brain chemicals when combined with ketamine. Participants received the drug or a placebo and had brain scans (MRI) to measure changes. The goal was to gather safety and b…

This early-stage study tested the safety and how the body handles ABBV-932, an experimental oral drug, in 20 healthy Chinese adults. Participants received multiple doses to measure how the drug moves through the body and to check for side effects. The goal was not to treat any di…

This study involved 49 healthy volunteers to test whether a special MRI technique can clearly show the different nerve pathways in the spinal cord. The goal was to create a detailed atlas of these pathways, which could help doctors better understand and treat spinal cord injuries…

This study tested a new drug called BIIB800 against the approved drug Actemra in 300 healthy men. The goal was to see if the body processes both drugs similarly and to check for side effects. Participants received a single injection and were monitored over time. No treatment was …

This study looked at how oxytocin, a natural brain hormone, changes the way people feel pain from heat. Twenty-five healthy adults and people with chronic pain rated their pain during skin heating before, during, and after receiving oxytocin through an IV. The goal was to create …

This study looked at whether inflammation is linked to heart disease and diabetes. Researchers compared 150 adults with these conditions to healthy volunteers using blood tests, heart scans, and tissue samples. The goal was to better understand the relationship, not to test a new…

This early-stage study tested a single dose of REGN9533 in 72 healthy adults to see if it is safe and how the body handles it. Researchers measured side effects, drug levels in the blood, and whether the body made antibodies against the drug. The goal is to gather safety data bef…

This early-stage study tested an experimental drug called SAGE-718 in 40 healthy adults. Researchers used a ketamine challenge to see how the drug affects brain activity and safety. The goal was to gather information, not to treat any disease.

This study looked at whether baked snacks made with cricket flour or pea flour make people feel fuller than regular wheat snacks. One hundred healthy adults tried all three snacks on different days and rated their hunger, fullness, and how much they liked the taste. The goal was …

This study looked at whether drinking a small amount of Calvados (a strong apple brandy) during a rich meal helps the stomach empty faster. Eight healthy adults ate a high-calorie meal and either had Calvados with sorbet or water with sorbet. Researchers used ultrasound to measur…

This early-stage study tested an experimental drug called SAGE-904 in 22 healthy adults to see how it affects brain electrical activity. Participants received either the drug or a placebo, then were given ketamine to temporarily change brain patterns. The goal was to measure brai…

This study looked at how different parts of the brain talk to each other. Researchers used brain scans and mild electrical stimulation to test a theory about brain waves. 157 healthy adults took part. The goal was to understand normal brain communication, not to treat any disease…

This study looked at 120 healthy volunteers to see how well three different methods (clinical observation, photography, and a special imaging system called EOS) measure pelvic extension. The goal was to describe the range of pelvic movement for four common body types. The study d…

This early-stage study tested the safety of an inhaled drug called RT234 in 31 healthy adults aged 18 to 45. Researchers measured side effects and how the drug moves through the body. The goal was to gather basic safety information before testing it in people with pulmonary arter…

This study checked if a single pill containing three diabetes drugs (gemigliptin, dapagliflozin, and metformin) works the same in the body as taking the three drugs separately. It involved 50 healthy adults aged 19 to 50. The goal was to compare how the drugs are absorbed and pro…

This study looked at how a natural gut hormone called GLP-1 affects bone turnover in 12 healthy adults. Participants received either GLP-1 or a saltwater solution for 72 hours using a small pump. Researchers measured changes in blood markers of bone formation and breakdown to und…

This early-stage study tested the safety and how the body processes a new drug called ABBV-CLS-616. It involved 110 healthy volunteers who took the drug by mouth. The main goal was to check for side effects and understand how the drug moves through the body. No treatment was give…

This study looked at how the experimental drug ABBV-1354 moves through and leaves the body in 8 healthy adult men. Participants took a single dose containing a tiny radioactive marker so scientists could measure the drug in blood, urine, and stool. The goal was to understand the …

This early-stage study looked at how two experimental drugs, AVP-786 and AVP-923, are processed by the body. It involved 62 healthy adults aged 18 to 60. The goal was to measure drug levels and check safety, not to treat any disease.

This early-stage study tested the safety and tolerability of a new drug called A-005 in 135 healthy adults aged 19 to 55. Participants received either single or multiple doses of the drug or a placebo. The goal was to check for side effects and how the drug moves through the body…

This study looked at how a single dose of the drug varegacestat affects the heart's electrical activity in 32 healthy adults aged 18 to 55. Participants received the drug, a placebo, or a positive control in random order. The goal was to see if varegacestat causes any changes in …

This early-phase study tested the safety and tolerability of a new drug called VNA-318 in 92 healthy male volunteers. Participants received either single or multiple doses of the drug or a placebo. The goal was to check for side effects and how the drug moves through the body, no…

This study looked at how a medical food containing tri-betahydroxybutyrin (3BHB) is absorbed and processed in the body. 18 healthy men aged 60 and older took the product and gave blood samples over 24 hours. The goal was to measure levels of certain substances in the blood, not t…

This study involved one healthy volunteer (the lead researcher) who gave himself an experimental virus therapy called OTS-412, which is designed to attack cancer cells. The goal was not to treat disease but to closely monitor how the immune system responds over time. Researchers …

This study tested a single dose of an experimental antibody drug (BMS-986446) in 46 healthy adults to see how well it is absorbed under the skin compared to into a vein. Researchers measured drug levels in the blood and checked for side effects. The results will help decide the b…

This study tested two different ways of taking the drug ARN-75039: as a tablet with extra ingredients or as a plain capsule. Sixteen healthy adults took both forms after a meal to see how well each was absorbed. The goal was to compare their pharmacokinetics, not to treat any dis…

This early-stage study tested the safety of a new drug called DD-S052P in 64 healthy adults. Participants received either the drug or a placebo through an IV, with some getting a single dose and others multiple doses over several days. The goal was to check for side effects and h…

This study looked at how well the drug risankizumab is absorbed when given through a wearable on-body injector compared to a standard injection. It involved 263 healthy adults and measured drug levels in the blood over time. The goal was to see if the new device delivers the drug…

This study tested how much of a pain-relieving gel (diclofenac) gets into the blood when applied once a day compared to a standard gel applied four times a day. Thirty-four healthy adults used each gel for 7 days. The goal was to see if the once-daily gel provides similar drug le…

This study gave 6 healthy men a single dose of a radioactive form of MT-8554 to see how the drug moves through the body and how it is eliminated in urine and stool. The goal was to measure absorption, breakdown, and excretion, not to treat any disease. Participants were healthy C…

This study looked at how people with long-term low back pain and healthy volunteers respond to pictures of everyday situations that might be painful. Researchers measured their balance, muscle activity, and heart rate while they looked at the images. The goal was to see if people…

This study tested a new investigational drug, SAR444336, in 76 healthy adults to see if it is safe and how the body handles it. Participants received either the drug or a placebo as single or repeated injections. The goal was to gather initial safety data before testing the drug …

This study looked at how a single dose of varegacestat moves through and leaves the body of 6 healthy adult men. Participants took a pill containing a tiny amount of radioactivity so scientists could track the drug in blood, urine, and stool. The goal was to understand absorption…

This study looked at how the drug varegacestat behaves in people with liver problems compared to those with healthy livers. Researchers gave a single dose to 35 adults and measured drug levels and side effects. The goal was to understand if liver impairment changes how the drug i…

This study measured how much pressure different hospital bed mattresses put on the tailbone area of healthy volunteers. Researchers tested two bed systems with volunteers lying flat and with their head slightly raised. The goal was to gather data to help understand how mattress d…

This study aimed to screen and observe people with neurological conditions and healthy volunteers to better understand these diseases. It enrolled over 3,800 participants to collect data and identify candidates for future research studies. No experimental treatments were tested—r…