HEALTHY VOLUNTEER

This early-stage trial tested the safety of a new drug called REGN9533 in 72 healthy adults. REGN9533 is a monoclonal antibody that blocks factor XII, a protein involved in blood clotting. The goal was to see if it is safe and how the body processes it, before testing it in peopl…

This study tested whether a quick, non-invasive ultrasound of the stomach can accurately detect if a child has too much fluid in their stomach before anesthesia. 92 healthy children aged 1-10 drank a set amount of clear liquid, then had a 3-minute ultrasound. The goal was to see …

This study tested whether a daily probiotic called LC-Plasma can prevent upper respiratory tract infections (like colds) in healthy adults aged 18-60 who often get sick. Over 600 participants took either the probiotic or a placebo pill every day for 24 weeks. Researchers tracked …

This study tested a single injection of nirsevimab in over 8,000 healthy infants under 1 year old to see if it could prevent hospitalizations from RSV, a common respiratory virus. Babies received either the shot or no intervention and were followed for up to 6 months. The goal wa…

This study tested whether taking carotenoids (natural pigments found in plants) by mouth can improve skin health and reduce visible signs of aging like wrinkles, dryness, and uneven tone. Researchers compared the supplement to a placebo in 80 healthy women aged 40-55. The goal wa…

This study tested whether a daily probiotic tablet (LC-Plasma) could boost the immune system and reduce cold symptoms in healthy adults. 241 Australian volunteers took either the probiotic or a placebo for 4 weeks. Researchers measured immune cell activity and tracked any upper r…

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This study collected blood, skin, and mucosal samples from 304 healthy volunteers and patients with skin or systemic diseases. The samples were used to support basic science and clinical research at the NIH. Participants included people of all genders and racial/ethnic groups, an…

This early-phase study looked at how the drug Mosliciguat moves through the body after being inhaled by 8 healthy adult men. Researchers measured how much of the drug reaches the bloodstream and how it is broken down and eliminated. The goal was to gather basic information, not t…

This completed study screened over 3,800 people with neurological conditions, their family members, and healthy volunteers. The goal was to gather information and create a pool of potential participants for future research studies. No experimental treatments were given, and docto…

This study looked at how different versions of an experimental drug, ABBV-932, are absorbed and processed by the body. Nine healthy adults took part to measure drug levels in the blood and check for side effects. The goal was to gather information, not to treat any disease.

This early-stage study tested a single dose of ENX-205 in 59 healthy adults to see if it is safe and how the body processes it. Researchers also used brain scans to measure how much of the drug reaches its target in the brain. The goal was to gather safety information, not to tre…

This completed Phase 1 study tested whether giving the drug litifilimab under the skin using an autoinjector or a wearable on-body injector works as well as using a traditional syringe. 404 healthy volunteers received the drug by one of the three devices. Researchers measured dru…

This study tested whether a tablet that dissolves in liquid works the same as the capsule form of the drug omaveloxolone (SKYCLARYS). The drug is already approved for Friedreich's ataxia, but some people have trouble swallowing capsules. Seventy healthy adults took both forms in …

This study tested four different formulations of a CGRP receptor antagonist, a drug used for migraines, in 64 healthy adults. The goal was to see if the different versions are absorbed and processed by the body in the same way. This is a Phase 1 trial, so it focuses on safety and…

This early-phase study tested a single dose of the experimental drug ABBV-142 in 73 healthy adults to check its safety and how the body handles it. The study also included a small group of Han Chinese participants to see if there are any differences. Since this is a phase 1 trial…

This study tested two different forms of the experimental drug ARN-75039 in 16 healthy adults to see how the body absorbs each form after a meal. Participants took a single dose of each form one week apart. The goal was to compare the drug levels in the blood, not to treat any di…

This early-stage trial tested the safety and how the body handles ABBV-8736 in 24 healthy adults. Participants received either the drug or a placebo through an IV. The goal was to check for side effects and measure drug levels in the blood, not to treat any disease.

This early-stage study enrolled 62 healthy adults to compare how two drugs, AVP-786 and AVP-923, are processed in the body. Participants received both drugs at different times to measure drug levels and safety. The goal was purely to gather information, not to treat any disease.

This completed study from the National Institute of Mental Health surveyed over 3,600 English-speaking adults online every two weeks for six months. Researchers asked about mental health symptoms, stress, and behaviors during the COVID-19 pandemic. The goal was to understand how …

This study tested whether a virtual reality program (DeepDream) can produce experiences similar to psychedelic drugs. Ten healthy volunteers took part at Yale University. Researchers measured changes in consciousness, mystical feelings, and sense of self. The goal was to see if V…

This study tested a small, radioactive dose of BIIB080, an experimental Alzheimer's drug, in 5 healthy adults to see how it spreads in the brain and spinal cord. Researchers used PET scans to track the drug after a single injection into the spinal fluid. The main goal was to unde…

This study looked at whether drinking calvados (a strong apple brandy) during a high-calorie festive meal helps digestion, as some people believe. Eight healthy volunteers ate a standardized 1850-calorie meal and either drank calvados with sorbet or water with sorbet. Researchers…

This study looked at how the drug varegacestat moves through the body in people with liver problems compared to healthy people. About 35 adults took a single dose, and researchers measured drug levels and side effects. The goal was to understand if liver impairment changes how th…

This early-phase study tested the safety and how the body processes a new drug called A-005 in 135 healthy adults. Participants received either single or multiple doses of A-005 or a placebo. The goal was to check for side effects and measure drug levels in the blood and spinal f…

This study tested two different ways to give the same drug (pegfilgrastim) to 180 healthy adults. One version uses a pre-filled syringe, the other an auto-injector. The goal was to see if the body absorbs and handles them the same way, and to check for side effects. No treatment …

This completed Phase 1 trial tested multiple doses of MLS101, a low-dose psilocybin capsule, in 20 healthy volunteers. Researchers used brain scans (fMRI) to see how the drug affects brain activity, while also checking safety and how the body processes the drug. The goal is to ga…

This early-stage study looked at how taking a new drug called icovamenib with or without food changes the way the body absorbs it. Sixty healthy adults took the capsule in different conditions to measure drug levels in the blood. The goal was to gather information for future dosi…

This study looked at whether doing virtual reality exercises with other people (multi-player) is more motivating than doing them alone. It included 86 participants: healthy teens, children with motor disorders, and older adults with conditions like stroke or COPD. Researchers mea…

This study looked at how a new drug called ESK-001 affects the heart's rhythm in 52 healthy adults aged 18 to 55. Participants received ESK-001, a placebo (fake drug), and moxifloxacin (a drug known to affect heart rhythm) at different times. The main goal was to see if ESK-001 c…

This study looked at how a natural gut hormone called GLP-1 affects bone health in 12 healthy volunteers. Participants received either GLP-1 or a saltwater solution for three days using a small pump. Researchers measured changes in bone formation and breakdown markers to understa…

This early-phase trial tested the safety and how the body processes a new drug called ABBV-CLS-616. It involved 110 healthy volunteers who took the drug or a placebo. The main goal was to check for side effects and understand how the drug moves through the body.

This early-phase trial tested the safety and tolerability of a new drug called DD-S052P in 64 healthy adults. Participants received either the drug or a placebo as an intravenous infusion, in single or multiple doses. The study monitored side effects, vital signs, and lab results…

This study tested whether a single pill containing three diabetes medicines (gemigliptin, dapagliflozin, and metformin) works the same in the body as taking them separately. Fifty healthy adults took either the combo pill or the separate drugs after a meal, and researchers measur…

This study tested how much of the pain-relieving drug diclofenac enters the bloodstream when applied as a gel to the knees. 34 healthy volunteers used a new once-daily gel (AMZ001) and a standard four-times-daily gel for 7 days each. The goal was to compare drug levels and check …

This completed Phase 1 study looked at how healthy men absorb, process, and eliminate a single oral dose of ABBV-1354 (Icalcaprant). Eight participants were monitored for side effects, vital signs, and drug levels in blood, urine, and feces. The goal was to understand the drug's …

This early-stage study tested the safety and how the body processes ABBV-932, an experimental oral drug, in 20 healthy Chinese adults. Participants received multiple doses to check for side effects and measure drug levels in the blood. Since this is a Phase 1 trial in healthy vol…

This study involved one healthy volunteer (the lead researcher) who gave himself a single dose of an experimental oncolytic virus called OTS-412. The goal was not to treat any disease but to closely monitor how the immune system responds immediately after the virus is given. Bloo…

This study looked at 120 healthy volunteers to see how well three different methods (in-person exam, photos, and a special X-ray system called EOS) measure pelvic extension. The goal was to describe pelvic movement patterns for four common body types. No treatment or intervention…

This study gave 6 healthy men a single oral dose of [14C]-MT-8554, a drug with a radioactive tag, to see how it is absorbed, broken down, and eliminated in urine and feces. Researchers measured drug levels in blood over time and checked for side effects. The goal was purely to un…

This study tested whether MT-8554, an experimental drug, changes the heart's electrical activity (QT interval) in 48 healthy adults aged 18 to 55. Participants received either a low dose, high dose, or a placebo. The goal was to measure safety, not to treat any disease. Results h…

This study tested a new, faster 6-lead ECG device that uses fewer stickers on the chest against the standard 12-lead ECG in 24 healthy adults. The goal was to see if the quick version gives the same heart measurements, which could make heart checks easier in busy clinics or ambul…

This early-phase trial tested the safety and tolerability of a new drug called VNA-318 in 92 healthy men. Participants received either a single or multiple doses of the drug or a placebo. The main goal was to check for side effects and understand how the drug moves through the bo…

This study aims to understand how different parts of the brain send information to each other. Researchers used brain scans and mild electrical stimulation in 157 healthy adults to test a theory about brain waves. The findings may help future research on brain disorders.

This study uses MRI to measure how the brain moves inside the skull during gentle head motions, like turning your head while swimming. Researchers will scan 90 healthy adults aged 18-65 as they perform small, repeated head movements. The goal is to develop a fast imaging method t…

This study measured the pressure on the tailbone (sacral area) from two different hospital bed systems: a low air loss mattress and a standard hospital mattress. 18 healthy adults were tested lying flat and with the head of the bed raised 30 degrees. The goal was to see which bed…

This early-stage trial tested an experimental drug called EP395 in 40 healthy adults. Researchers used a safe, temporary lung inflammation challenge to see how EP395 affects immune markers in the blood and lungs. The main goal was to gather safety data and understand the drug's e…

This completed Phase 1 study tested how well the drug risankizumab (SKYRIZI) is absorbed when given through an on-body injector compared to a standard injection. It involved 263 healthy adults and measured drug levels in the blood and any side effects. The goal was to see if the …

This study looked at how oxytocin, a natural brain hormone, might reduce pain from heat. 25 healthy adults and people with chronic pain rated their pain during skin heating before, during, and after receiving oxytocin through an IV. The goal was to create a model of how oxytocin …

This completed Phase 1 study in 22 healthy volunteers looked at whether omaveloxolone (a drug for Friedreich's ataxia) changes how the body processes omeprazole (a common stomach acid reducer). Participants took omeprazole alone and then together with omaveloxolone over 17 days. …

This study looked at how a new tablet form of the drug venetoclax is absorbed in the body. 72 healthy women took the drug under different conditions (with or without high-fat food) to measure drug levels and side effects. The goal was to gather information, not to treat any disea…

This study tested a new drug called BIIB800 against an approved drug, Actemra, in 300 healthy men. The goal was to see if the two drugs behave similarly in the body and are equally safe. Participants received a single injection and were monitored for side effects and drug levels.

This study looked at how a high-fat meal changes the way ABBV-101 moves through the body. Seventeen healthy adults took the drug with or without food. The goal was to measure safety and drug levels in the blood, not to treat any disease.

This study tested a single dose of an experimental drug called BMS-986446 in 46 healthy adults. The goal was to measure how the drug moves through the body and how well it is tolerated when given as a shot under the skin. The results will help design future studies for people wit…

This study looked at whether baked snacks made with cricket flour or pea flour make people feel fuller than regular wheat snacks. One hundred healthy adults tried all three snacks and rated their hunger, fullness, and taste. The goal was to see if these alternative proteins could…

This early-stage study tested a single dose of the investigational drug DR-01 in 32 healthy volunteers to check its safety and how the body processes it. Participants received either DR-01 or a placebo by injection under the skin. The goal was to gather safety information, not to…

This completed Phase 1 study gave six healthy men a single oral dose of varegacestat containing a tiny radioactive tracer. Researchers measured how much of the drug appeared in blood, urine, and feces to understand how the body absorbs, breaks down, and eliminates it. The study d…

This completed phase 1 study tested whether a single dose of varegacestat changes heart rhythm in 32 healthy adults. Participants received varegacestat, a placebo, and a control drug (moxifloxacin) in random order. The main goal was to measure any effects on the heart's electrica…

This study looked at how the body processes the drug omaveloxolone (SKYCLARYS®) when taken as a whole capsule versus when the capsule contents are sprinkled over low-fat yogurt. 52 healthy adults took the drug both ways to see if the body absorbs it differently. The goal is to of…

This early-phase trial tested the safety and how the body processes an inhaled form of vardenafil (RT234) in 31 healthy adults. Participants received single and multiple doses of the drug via an inhaler or as a pill. The study is complete and focused on side effects and drug leve…

This early-phase trial gave 22 healthy adults a single dose of SAGE-718 or a placebo, followed by a ketamine infusion, to see how the drug affects brain electrical activity. The study was completed and focused on safety and how the body processes the drug. Since it involved healt…

This completed Phase 1 trial tested a single dose of ARGX-109 in 40 healthy adults to see if it is safe and how the body processes it. Participants were randomly assigned to receive either the drug or a placebo. The study lasted about 20 weeks and focused on side effects and drug…

This Phase 1 study tested an experimental drug called SAGE-718 in 19 healthy volunteers. Participants received either SAGE-718 or a placebo, along with ketamine, to see how the drug affects brain chemicals like glutamate. The goal was to check safety and measure brain activity us…

This early-stage study tested a drug called SAGE-718 in 40 healthy adults. Researchers used a ketamine challenge to see how the drug affects brain electrical activity and safety. The goal was to gather basic information, not to treat any illness. This is a first step toward under…

This early-stage study tested a drug called SAGE-904 in 22 healthy volunteers to see how it changes brain activity after a ketamine challenge. Researchers measured brain waves using EEG to check if SAGE-904 alters responses to sounds. The goal was to understand how the drug works…

This early-phase study tested a new investigational drug called SAR444336 in 76 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo as a single or repeated injection. The goal was to gather safety data before movin…

This completed study looked at how a medical food containing tri-betahydroxybutyrin is absorbed and cleared from the body. Eighteen healthy men aged 60 and older took a single dose and gave blood samples over 24 hours. The goal was simply to measure levels of certain substances i…

This study looked at how people with chronic low back pain and healthy volunteers respond when they see pictures of everyday situations that might be painful. Researchers measured balance, muscle activity, and heart rate to see if the two groups react differently. The goal was to…

This study aims to create a detailed atlas of the spinal cord's nerve tracts using advanced MRI scans in 49 healthy adults. By combining brain and spinal cord imaging, researchers hope to better distinguish sensory and motor pathways. The goal is to improve diagnosis and surgical…