HEALTHY VOLUNTEER

This study tested how well a simple, non-invasive stomach ultrasound can detect if a child has a risky amount of fluid in their stomach before receiving anesthesia. Researchers worked with 92 healthy children, having them drink specific amounts of liquid and then using ultrasound…

This study tested a simpler heart monitor that uses just six stickers on the chest, comparing it to the standard 12-sticker test. Researchers wanted to see if the simpler device gives doctors the same accurate heart readings. The goal is to see if this faster, easier method could…

This study tested whether a daily tablet containing a specific probiotic bacteria (LC-Plasma) could help prevent common colds and flu. Over 240 healthy adults in Australia took either the probiotic or a placebo pill daily for four weeks. Researchers measured immune system activit…

This study tested whether taking a daily tablet containing a specific probiotic bacteria called LC-Plasma could prevent common colds and reduce their severity. Over 600 healthy adults in Australia who frequently get colds took either the probiotic or a placebo pill daily for six …

This study tested whether a single shot called nirsevimab could keep healthy infants under 1 year old out of the hospital due to RSV lung infections. Over 8,000 babies were randomly assigned to receive the shot or no intervention. Researchers then tracked them through the RSV sea…

This study tested whether playing virtual reality exercise games with others (multi-player) is more motivating than playing alone (single-player). It involved 86 participants including healthy teens, and people with conditions like stroke, COPD, or cerebral palsy. Most tried both…

This study tested whether taking an oral carotenoid supplement called CaroRite™ improves skin health and reduces visible signs of aging. It involved 80 healthy women aged 40-55, who took either the supplement or a placebo pill. Researchers used special scanners and probes to meas…

This study developed new MRI techniques to measure how the brain moves and deforms during mild head motions in healthy volunteers. Researchers scanned 101 healthy adults aged 18-65 while they performed controlled head movements in an MRI machine. The goal was to create detailed 3…

This early-stage study tested an experimental drug called SAGE-718 in healthy volunteers. Researchers gave participants either the drug or a placebo, along with a single dose of ketamine, to see how it affected brain chemicals measured by MRI scans. The main goal was to check the…

This early-stage study tested an experimental drug called SAGE-718 in 40 healthy volunteers. Researchers gave participants either SAGE-718 or a placebo, then used a low dose of ketamine to temporarily alter brain activity and measure the drug's effects. The main goals were to che…

This early-stage study tested how eating food affects the way the body absorbs a new drug called icovamenib. Sixty healthy volunteers took the drug in capsule form, sometimes on an empty stomach and sometimes with meals of different fat content. Researchers measured drug levels i…

This study tested a new pill that combines three common diabetes medications into one. Researchers gave the combined pill and the separate pills to 50 healthy adults to see if the body processes them the same way. The goal was to check if the new single pill works as well as taki…

This early-stage study aimed to see if a single dose of an experimental drug called varegacestat affects the heart's electrical rhythm. It involved 32 healthy adults who received the drug, a placebo, and a known heart-affecting drug for comparison. The main goal was to gather saf…

This study screened over 3,800 people to better understand neurological conditions and identify participants for future research. It evaluated patients with nervous system disorders, their family members, and healthy volunteers. No experimental treatments were given—the goal was …

This was the first study to give a new experimental drug called REGN9533 to people. The main goal was to check if the drug is safe and to find a good dose in 72 healthy volunteers. This early research is a necessary first step before testing the drug in people who have blood clot…

This early-stage study tested a single dose of an experimental antibody drug, BMS-986446, in 46 healthy people. The main goal was to understand how the body processes the drug when given as a shot under the skin versus into a vein, and to check for any side effects. This type of …

This early-stage study tested whether an oral drug called EP395 could reduce markers of lung inflammation in healthy adults. Researchers gave 40 participants either EP395 or a placebo for 21 days, then used a safe, inhaled substance to temporarily cause mild airway inflammation t…

This study aimed to understand how the body absorbs and eliminates a specific ingredient (tri-betahydroxybutyrin) found in a medical food. Researchers enrolled 18 healthy men aged 60 and over to take the product and then tracked its levels in their blood over 24 hours. The goal w…

This was the first study to test a new drug called DR-01 in people. The main goal was to check if it was safe and to see how the body processes it. The study involved 32 healthy volunteers who received either the drug or a placebo as a single injection. Researchers monitored part…

This study aimed to understand how the hormone oxytocin affects pain when given through an IV. Researchers tested 25 healthy volunteers and people with knee arthritis by applying heat to their skin and measuring pain levels before, during, and after receiving oxytocin. The goal w…

This study aimed to see how much of a new, once-daily diclofenac gel (AMZ001) gets into the bloodstream compared to a standard gel applied four times a day. It involved 34 healthy volunteers who applied each gel to their knees for one week. The main goal was to measure drug level…

This early-stage study aimed to understand how a new drug called MT-8554 is absorbed, processed, and eliminated by the body. Six healthy male volunteers took a single oral dose containing a tiny, safe amount of radioactive tracer to help track the drug. Researchers measured drug …

This was an early safety study to see how healthy people's bodies handled a new inhaled drug called RT234. Researchers tested single and repeated doses in 31 healthy volunteers to check for side effects and measure how the drug moved through the body. The drug is being developed …

This study tested whether three different injection devices deliver the same amount of litifilimab into the bloodstream. Researchers compared a standard syringe against an auto-injector pen and a wearable on-body injector in 404 healthy volunteers. The goal was to see if the newe…

This early-stage study aimed to understand how the body absorbs, breaks down, and eliminates the drug varegacestat. Six healthy adult men received a single oral dose containing a tiny, safe amount of radioactive tracer. Researchers collected blood, urine, and stool samples for ov…

This study aimed to understand how an experimental drug called SAGE-904 affects brain activity. Researchers gave 22 healthy volunteers either SAGE-904 or a placebo, then measured their brain waves before and after receiving a low dose of ketamine. The goal was to see if SAGE-904 …

This was the first study in people to test a new oral drug called A-005. It aimed to see if the drug is safe, what side effects it might cause, and how the body absorbs and processes it. The study involved 135 healthy adult volunteers who took either the drug or a placebo. A smal…

This study aimed to see if a drug for Friedreich's Ataxia (FA) works the same way in the body when sprinkled on low-fat yogurt as it does when taken as a whole capsule. It involved 52 healthy adults who tried both methods. The goal was to learn if yogurt could be another simple o…

This study aimed to collect blood and skin samples from healthy volunteers and people with certain skin or other diseases. The samples were used to support basic science and medical research at the National Institutes of Health. The study did not test a treatment; its purpose was…

This study tested how eating a high-fat meal affects how the body absorbs and processes a new oral medicine called ABBV-101. It involved 17 healthy adult volunteers to measure the drug's levels in the blood after taking it with and without food. The goal was to gather basic safet…

This was an early safety study to see if a new drug called ARGX-109 is safe for people and how it moves through the body. It involved 40 healthy adults who received a single injection. The main goal was to check for side effects and measure drug levels in the blood over about 20 …

This was the first study to test a new drug called DD-S052P in humans. It aimed to see if the drug is safe and how the body processes it. The study involved 64 healthy adult volunteers who received either the drug or a placebo through an IV. Researchers monitored participants clo…

This study tested how the body absorbs the drug risankizumab when delivered using a new, wearable on-body injector. It involved 263 healthy adult volunteers. The main goal was to measure drug levels in the blood and check for safety, not to treat any disease.

This early-stage study tested a new oral drug called SAGE-718 in healthy volunteers. Researchers gave participants SAGE-718 or a placebo along with ketamine to see how it affects brain wave patterns and to check if it's safe. The main goal was to gather information about the drug…

This study aimed to understand if a drug called omaveloxolone (approved for a rare nerve disease) changes how the body processes omeprazole, a common heartburn medication. Researchers tested this in 22 healthy volunteers over about 45 days by giving them both drugs and taking blo…

This early-stage study aimed to understand how a single dose of an experimental drug, varegacestat, is processed by the body in people with different levels of liver impairment compared to healthy people. It involved 35 adults, some with liver problems and some without, to measur…

This early-stage study aimed to see if a new drug called BIIB800 behaves similarly in the body to an existing drug, Actemra. It involved 300 healthy male volunteers who received a single injection of one of the drugs. Researchers measured drug levels in the blood, safety, and the…

This early-stage study aimed to understand how an experimental Alzheimer's drug, BIIB080, travels through the brain and spinal cord. Researchers gave a tiny, traceable dose of the drug to 5 healthy adults and used special brain scans to see where it went. The main goals were to m…

This early-stage study tested a new drug called ESK-001 in 52 healthy people. The main goal was to see if the drug affects heart rhythm and to measure how the body absorbs and processes it. Researchers compared ESK-001 to a dummy pill (placebo) and a known antibiotic to check for…

This study aimed to understand how thinking about painful activities affects the body's posture and muscle tension in people with chronic low back pain. Researchers compared 34 people, some with back pain and some without, by showing them pictures of everyday painful situations a…

This study aimed to create a detailed map of the tiny nerve pathways inside the spinal cord. Researchers used a special type of MRI scan on 49 healthy volunteers to try to trace and identify these pathways. The goal is to build a reference atlas that could help doctors better und…

This study aimed to understand how the body processes and eliminates an experimental drug called ABBV-1354 (Icalcaprant). Eight healthy adult men received a single oral dose containing a tiny, safe amount of radioactive carbon to help track the drug. Researchers measured how much…

This study aimed to see if a new pegfilgrastim auto-injector works similarly to an existing pre-filled syringe. Pegfilgrastim is a drug used to help cancer patients fight infections during chemotherapy. The study involved 180 healthy adults who received both devices to compare ho…

This early-stage study tested how a new oral compound called ABBV-932 moves through the body and checked for side effects. It involved 20 healthy Chinese adult volunteers to gather basic safety and dosing information. The main goal was to understand how the body processes the dru…

This early-stage study tested whether an experimental drug called MT-8554 affects the heart's electrical rhythm in healthy adults. Researchers gave 48 healthy volunteers either the drug at two different doses or a placebo (inactive substance) and carefully monitored their heart a…

This study aimed to understand how much pressure different hospital beds put on a person's tailbone area when lying flat or with the head slightly raised. Researchers measured this pressure on 18 healthy volunteers for 15 minutes on each bed. The goal was to gather basic informat…

This study tested a common French belief that drinking a shot of Calvados brandy during a big meal helps with digestion. Eight healthy volunteers ate a large, high-calorie meal and had their stomach emptying measured with ultrasound. Researchers compared what happened when volunt…

This study aimed to understand how snacks made with cricket flour or pea flour compare to a regular wheat snack. One hundred healthy adults tried all three snacks on different days. Researchers measured how full people felt, how much they liked the taste, and if the snacks caused…

A single, healthy researcher injected themselves with an experimental virus designed to fight cancer. The goal was to track in real-time how the body's immune system reacts immediately after receiving the virus, which is very hard to measure in regular patients. This was a very e…

This study aimed to understand how a natural gut hormone called GLP-1 affects bone health. Researchers gave 12 healthy volunteers either the hormone or a saline solution for three days to see how it changed markers of bone building and breakdown. The goal was to gather basic know…

This study tested how a new version of the cancer drug venetoclax is absorbed by the body. It involved 72 healthy female volunteers to compare the new tablet to the current one and see if eating food changes how the drug works. The goal was to gather information to potentially im…

This early-stage study tested a low-dose form of psilocybin, the compound found in 'magic mushrooms,' in 20 healthy volunteers. Researchers used brain scans (fMRI) to see how the drug affects brain activity and connections. The main goals were to check the drug's safety, how the …

This was an early-stage study to check the safety and see how the body processes a new drug called SAR444336. It involved 76 healthy adult volunteers who received either the drug or a placebo. The main goal was to gather basic safety information and understand how the drug moves …

This study aimed to establish normal measurements for how much the pelvis can extend backward in healthy people. Researchers compared three different measurement methods—physical exam, photography, and a specialized low-dose X-ray system—in 120 healthy volunteers. The goal was to…

This early-stage study tested a new oral drug called ABBV-CLS-616 in healthy volunteers for the first time. Researchers wanted to understand how safe the drug is, how well people tolerate it, and how the body processes it. The study involved 110 healthy participants and examined …

This study aimed to understand how different specialized areas of the brain communicate to create thoughts and actions. Researchers used advanced brain scanning and gentle stimulation techniques on 157 healthy volunteers to test a theory about how brain waves help direct informat…

This was the first-ever study in people for a new oral drug called VNA-318. Its main goal was to check the safety and see how the body processes the drug in healthy male volunteers. Researchers tested single and multiple doses on 92 men to find a safe dose range for future studie…

This study aimed to understand the connection between inflammation and common health conditions like heart disease and diabetes. Researchers compared 150 adults with these conditions to healthy volunteers using blood tests, questionnaires, and special body scans. The goal was to …