Brain drug SAGE-718 tested in healthy people – no cure yet
NCT ID NCT03844906
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-stage study tested a drug called SAGE-718 in 40 healthy adults. Researchers used a ketamine challenge to see how the drug affects brain electrical activity and safety. The goal was to gather basic information, not to treat any illness. This is a first step toward understanding if SAGE-718 might be useful for brain conditions in the future.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SAGE-718
What this could lead to
If successful, this could help researchers understand how SAGE-718 affects brain activity, potentially guiding future studies for conditions like Alzheimer's or Parkinson's.
What could go wrong
This is a very early Phase 1 study in only 40 healthy people, not patients. It is designed to test safety and brain effects, not to treat any disease. Results may not lead to a treatment.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Sage Investigational Site
Long Beach, California, 90806, United States
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Sage Investigational Site
Berlin, New Jersey, 08009, United States