New imaging method could reveal hidden inflammation in Alzheimer's brains

NCT ID NCT04274998

Ongoing Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses special PET scans to look for signs of inflammation in the brains of people with Alzheimer's disease or mild cognitive impairment, compared to healthy volunteers. Nine participants will receive an investigational radioactive tracer called [18F]NOS, and some may also get a second tracer, [11C]PBR28, for comparison. The goal is to see whether these scans can detect inflammation and how it relates to other Alzheimer's brain changes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: [18F]NOS and [11C]PBR28 (investigational radiotracers for PET imaging)
What this could lead to: If successful, this could help researchers better understand how inflammation relates to Alzheimer's disease, potentially guiding future treatments.
What could go wrong: This is a very small, early-phase imaging study with only 9 participants, so results may not apply broadly. The tracers are investigational and not yet proven to be useful in routine care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE HEALTHY VOLUNTEER

Contacts and locations

Locations

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

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