New imaging method could reveal hidden inflammation in Alzheimer's brains
NCT ID NCT04274998
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study uses special PET scans to look for signs of inflammation in the brains of people with Alzheimer's disease or mild cognitive impairment, compared to healthy volunteers. Nine participants will receive an investigational radioactive tracer called [18F]NOS, and some may also get a second tracer, [11C]PBR28, for comparison. The goal is to see whether these scans can detect inflammation and how it relates to other Alzheimer's brain changes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
[18F]NOS and [11C]PBR28 (investigational radiotracers for PET imaging)
What this could lead to
If successful, this could help researchers better understand how inflammation relates to Alzheimer's disease, potentially guiding future treatments.
What could go wrong
This is a very small, early-phase imaging study with only 9 participants, so results may not apply broadly. The tracers are investigational and not yet proven to be useful in routine care.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States