New antibody aims to quiet seizures

NCT ID NCT07051629

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a new drug called SIF001, a monoclonal antibody designed to treat epilepsy. Researchers are giving the drug to healthy volunteers and people with epilepsy to check its safety, how the body processes it, and what side effects may occur. The study uses a placebo for comparison and gradually increases the dose to find the safest range.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
SIF001 (a monoclonal antibody)
What this could lead to
If safe and effective, SIF001 could offer a new way to control seizures in people with epilepsy.
What could go wrong
This is an early Phase 1 trial focused on safety, not yet on effectiveness. The drug may not work or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Accel Research sites network

    RECRUITING

    DeLand, Florida, 32720, United States

  • Center for Neurosciences

    RECRUITING

    Tucson, Arizona, 85718, United States

    Contact Email: •••••@•••••

  • D&H Tamarac Research Center, LLC

    RECRUITING

    Tamarac, Florida, 33321, United States

  • Dent Neurologic Institute

    RECRUITING

    Amherst, New York, 14226, United States

  • Encore Medical Research of Weston, LLC

    RECRUITING

    Weston, Florida, 33331, United States

  • Hawaii Pacific Neuroscience, Comprehensive Epilepsy Center

    RECRUITING

    Honolulu, Hawaii, 96817, United States

    Contact Email: •••••@•••••

  • Horizon Clinical Research Center

    RECRUITING

    Cypress, Texas, 77429, United States

    Contact Email: •••••@•••••

  • Mid-Atlantic Epilepsy and Sleep Center

    RECRUITING

    Bathesda, Maryland, 20817, United States

  • OnSite Clinical Solutions, LLC

    RECRUITING

    Charlotte, North Carolina, 28277, United States

  • Quest Research Institute

    RECRUITING

    Farmington Hills, Michigan, 48334, United States

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