New oxycodone combo aims to curb abuse – first human test underway
NCT ID NCT06500793
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests how a new form of oxycodone (PF614) combined with nafamostat behaves in the body. Fifty-four healthy adults will receive single doses to measure drug levels and safety. The goal is to see if this combination can reduce misuse potential while still providing pain relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PF614 (oxycodone prodrug) and nafamostat mesylate
What this could lead to
If successful, this could help develop a safer painkiller that reduces abuse potential by combining a prodrug with a blocker.
What could go wrong
This is a very early Phase 1 study in only 54 healthy people, so it cannot prove the drug works for pain or is safe long-term. Side effects are possible.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Quotient Sciences
RECRUITINGMiami, Florida, 33126, United States
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