PHARMACOKINETICS

This early-stage study is testing a new version of the pain medication oxycodone. The new pill, called PF614-MPAR, contains a second ingredient meant to block the drug's effects if someone takes more than the prescribed dose by accident. Researchers will give single doses to 30 h…

This early-stage trial is testing a new oral medication called IPG7236 in adults with advanced solid tumors that have stopped responding to standard treatments. Researchers will first determine safe dosage levels and then expand to specific cancer types including kidney, breast, …

This study aims to find out if the standard antibiotic doses given to critically ill babies and children in intensive care are effective. Researchers will measure antibiotic levels in the blood of up to 640 young patients to see if the doses are high enough to fight infections. T…

This is the first study in humans to test a new inhaled compound called RCS-21. The main goal is to check if it is safe and how the body processes it. Healthy volunteers will inhale a single dose and be closely monitored for side effects. This is an early, basic safety study, not…

This study aims to understand how smoking high-strength cannabis affects feelings of pleasure and pain tolerance in people who use it regularly. Researchers will test 30 participants by having them smoke different strengths of cannabis, including a fake version, and measure their…

This early-stage study aims to check the safety and measure how the body processes a new combination antibiotic drug. Researchers will enroll 46 healthy adults to receive the medication and monitor them for side effects. The study focuses on understanding how the drug moves throu…

This study aims to find out if the standard antibiotic doses given to critically ill babies and children on ECMO (a heart-lung machine) are strong enough to fight infections. Researchers will measure drug levels in the blood of 300 young patients to see if the current doses hit t…

This early-stage study aims to understand how two different versions of the cholesterol-lowering drug evolocumab are absorbed and processed by the body. It will involve 400 healthy adults who will receive a single dose. The main goal is to compare how much of each drug version ge…

This is an early safety study testing a new drug called BB-025, both by itself and after another drug called BB-031. The main goal is to see how safe these drugs are and how they move through the body in 72 healthy volunteers. Participants will be monitored for 28 days to check f…

This study aims to understand how the bodies of critically ill children process the antifungal drug caspofungin. It will observe 60 children in intensive care who are already receiving this medication. The goal is to gather data to help doctors determine the safest and most effec…