PHARMACOKINETICS

This early-phase study tested a new drug called boserolimab (MK-5890), either alone or combined with pembrolizumab, in 182 adults with advanced solid tumors (including lung and triple-negative breast cancers). The main goal was to check safety and how the drug moves through the b…

This study tested a new way to give the antibiotic cefoxitin to prevent infections after colorectal surgery. Instead of the standard one-size-fits-all dose, a computer-controlled pump delivered a personalized amount based on each patient's weight and kidney function. About 2,500 …

This early-stage study tested the safety of a new drug called BB-025 in 72 healthy adults. Some participants received BB-025 alone, while others got it after another drug, BB-031. The goal was to see if BB-025 is safe and how the body processes it, not to treat any disease.

This study looked at how the sedative ciprofol is processed in the blood of 36 people with moderate to severe hypoproteinemia (low blood protein). Researchers measured drug levels at different times after a single injection. The goal was to understand how low protein changes the …

This study looked at how moderate liver problems affect the way the body handles a new cancer medicine called sevabertinib. About 20 people (10 with liver impairment and 10 healthy) took a single dose and had their blood levels measured. The goal is to help doctors decide the rig…

This study looked at how a single dose of the antibiotic combination ceftibuten/VNRX-7145 moves through the body in 32 adults with normal kidney function, mild to severe kidney problems, or end-stage kidney disease on dialysis. Researchers measured drug levels in the blood and ch…

This study looked at how safe kratom is and how the body processes it. Forty healthy adults who use opioids recreationally took single doses of kratom. Researchers monitored side effects and measured drug levels in the blood to better understand kratom's effects.

This study looked at how the experimental drug MRX1 is processed by the body, its safety, and whether food changes its effects. Twenty healthy adults took multiple doses of MRX1. The goal was to gather basic information, not to treat any disease.

This study tested whether a new rapid-acting insulin (I004) works the same as the approved insulin NovoLog. Sixty-nine healthy adults received single doses of both insulins in a blinded, crossover design. The goal was to measure how the body absorbs and responds to each insulin, …

This study looked at how taking a new antibiotic combination (ceftibuten/VNRX-7145) with or without food changes the way the body absorbs the medicine. It involved 24 healthy adults who received a single dose under both conditions. The goal was to gather safety and drug-level inf…

This study tested how the body handles noribogaine and whether it is safe in healthy adults. Fifty-five volunteers received either the drug or a placebo. The goal was to measure drug levels and side effects, not to treat any disease.

This study looked at how two antibiotics, ceftibuten and ledaborbactam, travel through the blood and lungs in 34 healthy adults aged 18 to 55. Participants took the drugs by mouth and then had a bronchoscopy to collect lung fluid samples. The goal was to measure drug levels in th…

This study tested whether a computer model could help doctors give the right dose of anti-rejection drugs to children after a kidney transplant. 29 children took part, and their drug levels were measured to see how well the model predicted the best dose. The goal was to make trea…

This early-stage study tested a vaginal ring that slowly releases two medicines (dapivirine and levonorgestrel) over 90 days to prevent HIV and pregnancy. Forty healthy HIV-negative women used the ring to check how much drug gets into the body and if it causes any side effects or…

This study tested if giving the drug pasireotide with a reusable pen works as well as using a traditional syringe. Forty healthy adults received single doses by both methods. The goal was to see how the body processes the drug and if the pen is safe to use.

This study tested a new slow-release version of the drug pyridostigmine in 40 healthy adults. The goal was to see how the body processes the new tablet compared to the regular one, and to check for any side effects. Participants took both versions at different times so the resear…