PHARMACOKINETICS

This study compares a new rapid-acting insulin (I004) to the approved NovoLog in 60 healthy adults. Researchers measure how fast the insulin enters the blood and how well it controls blood sugar using a special clamp technique. The goal is to show the two insulins work the same, …

This early-phase trial tests an experimental oral drug called IPG7236 in people with advanced solid tumors that have spread or cannot be removed. The study has two parts: first, finding a safe dose, then expanding to see if the drug can control tumor growth. About 196 participant…

This early-phase study tested a new drug called boserolimab (MK-5890), either alone or combined with the immunotherapy pembrolizumab (KEYTRUDA), in 182 adults with advanced solid tumors, including lung and breast cancers. The main goals were to check safety and how the drug moves…

This study tested whether giving the antibiotic cefoxitin using a target-controlled infusion pump works better than the standard method to prevent surgical site infections in patients having colon or rectal surgery. About 2,500 adults took part. The goal was to see if the new met…

This early-stage trial is testing whether Natrunix, an antibody that targets a key inflammatory protein called IL-1-alpha, is safe and how it behaves in the body. About 24 healthy adults will receive either Natrunix or a placebo via injection, with doses increasing across groups.…

This study looks at how quickly and effectively oral calcium is absorbed into the blood of pregnant women during labor. Participants receive a single dose of calcium carbonate (like Tums) or calcium citrate, and blood calcium levels are tracked over four hours. The goal is to und…

This early-stage study tests a new crystallized form of lithium (AL001) against standard lithium carbonate in 6 healthy adults. Participants take each drug for 14 days and undergo MRIs and blood draws to compare how much lithium reaches the brain. The goal is to see if AL001 is s…

This study investigates how compounds in apples, called polyphenols, interact with reactive carbonyl species—potentially harmful molecules—in healthy adults. Twelve participants consume a single large serving of apple blend, and researchers track the formation and breakdown of th…

This completed Phase 4 trial studied how sugammadex, a drug that reverses muscle relaxants, works in 48 patients undergoing laparoscopic surgery. Researchers measured drug levels in the blood and how quickly patients recovered muscle function. The study focused on patients with a…

This early-phase trial tested the safety of a new drug called BB-025, designed to reverse the effects of another experimental drug, BB-031. 72 healthy volunteers received either BB-025 or a placebo, alone or after BB-031, and were monitored for 28 days. The main goal was to check…

This study tested a vaginal ring that slowly releases two medicines: dapivirine (to prevent HIV) and levonorgestrel (a contraceptive). Forty healthy women without HIV used the ring for 90 days. Researchers measured drug levels in blood and vaginal fluid and checked for side effec…

This study tested whether a new rapid-acting insulin (called I004) works the same as the approved insulin NovoLog. Sixty-nine healthy volunteers each received a single dose of both insulins at different times, and researchers measured how quickly the insulin entered the blood and…

This study looks at how moderate liver problems change the way the body handles sevabertinib, an experimental cancer drug for tumors with HER2 mutations. About 20 people—10 with liver impairment and 10 healthy volunteers—will take a single dose and have their blood levels measure…

This study looked at how the investigational drug MRX1 is processed by the body, its safety, and whether food changes its absorption. Twenty healthy adults took multiple doses of MRX1. The goal was to gather basic information, not to treat any disease.

This study tested whether giving the drug pasireotide with a reusable pen works as well as using a traditional syringe. Forty healthy adults received a single dose by both methods to compare how the drug enters the body and if it is safe. The goal is to find a more convenient way…

This completed Phase 1 study tested how two antibiotics, ceftibuten and ledaborbactam, move through the blood and lungs of 34 healthy adults aged 18-55. Participants took five doses of the drugs and underwent a bronchoscopy to measure drug levels in lung fluid. The goal was to un…

This early-stage trial tested the safety and drug levels of noribogaine in 55 healthy adults aged 18 to 45. Participants received either the drug or a placebo, and researchers measured how the drug was processed by the body. The goal was to gather safety information, not to treat…

This early-stage study tested how a single dose of the antibiotic combination ceftibuten/VNRX-7145 is processed by the body in 32 adults with normal or impaired kidney function, including those on dialysis. Researchers measured drug levels in the blood and monitored safety. The g…

This study tested whether taking a new antibiotic (ceftibuten/VNRX-7145) with food changes how the body absorbs it. Twenty-four healthy adults took the drug once while fasting and once after a meal. Researchers measured drug levels in the blood to see if food affects safety or ef…

This study tested whether a computer model can help doctors give the right dose of anti-rejection drugs to children after a kidney transplant. The model used drug levels from blood samples to predict future exposure and guide dosing. 29 children participated, and the goal was to …

This study looked at how the sedative drug ciprofol is processed in the body of people with moderate to severe low blood protein (hypoproteinemia). Researchers measured drug levels in the blood after a single injection in 36 patients. The goal was to understand dosing and timing,…

This completed study tested single doses of kratom in 40 healthy adults who have used opioids recreationally. Researchers measured safety, side effects, and how the body processes kratom. The goal was to gather basic information, not to treat any condition.

This study tested a new sustained-release (long-acting) version of pyridostigmine, a drug used for myasthenia gravis (a muscle weakness disease). Forty healthy Chinese adults took both the new long-acting tablet and the standard immediate-release tablet at different times to comp…