PHARMACOKINETICS

This early-stage study aimed to find a safe dose and understand how the body processes a new experimental drug called boserolimab. It involved 182 adults with advanced cancers, including lung and breast cancer, who had run out of standard treatment options. Researchers tested bos…

This study tested a computer-based method to personalize medication doses for children who had a kidney transplant. The goal was to better control the levels of two key anti-rejection drugs in the body. Doctors used the tool to recommend doses, then checked later to see if the pr…

This study tested a new, more precise way to give a common antibiotic (cefoxitin) before colon or rectal surgery. Researchers compared a standard IV push to a 'smart pump' that adjusts the dose based on a patient's weight and kidney function. The goal was to see if this personali…

This study aims to understand how liver disease changes the way the body processes an experimental cancer drug called sevabertinib. Researchers compared about 20 people—half with moderate liver problems and half with healthy livers—after each took a single dose. By measuring drug…

This completed early-stage study tested how the body absorbs and processes a compound called noribogaine, and checked its safety. It involved 55 healthy adults who received either the compound or a placebo over eight days. The main goal was to gather basic information about how t…

This study aimed to gather basic safety information about kratom, a plant some people use for pain or anxiety. It tested single, increasing doses in 40 healthy adults who have experience with recreational drugs like opioids. Researchers measured side effects, how the body process…

This study tested whether a reusable pen device delivers a drug called pasireotide into the body the same way as a standard syringe. It involved 40 healthy adults who received single doses using both methods. The goal was to check if the pen is a safe and effective alternative fo…

This study aimed to understand how a new antibiotic combination is processed by the body in people with varying levels of kidney function. It involved 32 adults, some with healthy kidneys and others with mild to severe kidney problems. Researchers gave a single dose and measured …

This study tested a new, potentially lower-cost copy (biosimilar) of a fast-acting insulin called NovoLog. The goal was to see if the new insulin behaves the same way in the body as the original. Healthy volunteers received both insulins in a carefully controlled setting to measu…

This study aimed to understand how a sedative drug called ciprofol is processed by the body in patients with low blood protein levels. Researchers gave a single dose to 36 patients before surgery and took multiple blood samples over four hours to measure drug levels. The goal was…

This study tested how eating food affects how the body absorbs and processes an experimental antibiotic combination called Ceftibuten/VNRX-7145. It involved healthy adult volunteers who took the drug once while fasting and once after a meal. The goal was to understand if food cha…

This study aimed to understand how a new oral CBD solution, called MRX1, is processed by the body and to check its safety. It involved 20 healthy adult volunteers who took the drug for several weeks. Researchers measured drug levels in the blood and checked for side effects, incl…

This study tested a new, long-acting version of a drug used for myasthenia gravis, a condition that causes muscle weakness. Researchers compared how the body absorbs and handles this new pill versus the standard pill. The study was done with 40 healthy volunteers to check for saf…

This early-stage study aimed to understand how two experimental antibiotics, ceftibuten and ledaborbactam, move from the blood into the lungs after people take them by mouth. Researchers gave the drugs to 34 healthy adults and collected samples from their blood and lung fluid to …