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Apples' hidden power: study probes how polyphenols scavenge harmful carbonyls

NCT ID NCT03911050

Knowledge-focused Sponsor: North Carolina Agriculture & Technical State University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study investigates how compounds in apples, called polyphenols, interact with reactive carbonyl species—potentially harmful molecules—in healthy adults. Twelve participants consume a single large serving of apple blend, and researchers track the formation and breakdown of these compounds in blood and urine. The goal is to better understand the body's natural defenses and the potential health benefits of apples.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
apple polyphenols
What this could lead to
If successful, this could help explain how apples may protect against oxidative stress and related diseases.
What could go wrong
This is a very small, early-stage study in healthy people, so results may not apply to broader populations or lead to direct health advice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

Nov 2018

Finished

Dec 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI between 17 and 30 * Have blood and urine biochemical markers in normal range * Have no known allergy to apples * Be not taking antibiotics for six months * Be not currently taking medication * Be nonsmoking * Have no alcoholic intoxication * Have no extensive exposure to industrial wastes * Be not frequent charred meat consumption Exclusion Criteria: * Individuals with gout * Individuals with heart diseases * Individuals with peripheral vascular diseases * Individuals with degenerative kidney * Individuals with degenerative liver * Cancer patients * Patients with diabetes * Individuals with GI disorders * Individuals with endocrine disorders

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Human health Pharmacokinetics Polyphenols

Contacts and locations

Locations

  • North Carolina Agriculture and Technical State University

    Kannapolis, North Carolina, 28081, United States

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