Could apples and green tea shield cells from aging damage?
NCT ID NCT07767149
First seen Aug 17, 2026 · Last updated Aug 25, 2026 · Updated 3 times
Summary
This study tests whether eating a diet rich in flavonoids—found in apples, blueberries, soy milk, and green tea—can lower carbonyl stress, a type of cell damage linked to aging and chronic disease. Healthy adults aged 25-70 will follow both a high-flavonoid and a low-flavonoid diet for three weeks each, in random order. Researchers will measure flavonoid metabolites and carbonyl stress markers in blood and urine to see if the high-flavonoid diet makes a difference.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- High-flavonoid diet (apple, blueberry powder, soy milk, green tea) compared to a low-flavonoid diet
- What this could lead to
- If high-flavonoid foods lower carbonyl stress, it could point to dietary ways to reduce cell damage linked to aging and chronic disease.
- What could go wrong
- This is a small, early study in healthy adults, so results may not apply broadly. It measures biomarkers, not health outcomes, and the effect may be modest.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 36 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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25 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 25-70 years * BMI between 18 and 30 * Have no known allergy to test food * Have no known allergies to green tea, apples, blueberries, soy milk, or pineapples * Be not engaging in high-intensity exercise * Having blood and urine clinical tests in the normal range. * Be not taking antibiotics for six months * Be not currently taking medication * No taking any prescription drugs * All flavonoid-enriched supplements should be avoided. The flavonoid-enriched supplements list includes soy isoflavones, Lipo-Flavonoid, Citrus Bioflavonoids Complex, Super Flavonoids, Super Antioxidants, Quercetin Supplement, Essential-C, flavonoids, and milk thistle. Also other flavonoid supplements, including but not limited to luteolin, Rutin, etc. * No drugs or supplements within three weeks of the experiment * Be nonsmoking * Have no alcoholic intoxication * No alcoholic addiction * \< 3-4 drinks per week (less than 2 glasses (300 mL) per drink) * No alcohol within three weeks of the experiment * Have no extended exposure to industrial wastes Exclusion Criteria: * Disease: gout, heart disease, peripheral vascular disease, degenerative kidney, degenerative liver, diabetes, GI disorders, or endocrine disorders * Cancer patients * Currently diagnosed cancer patients will be excluded. * Medication-free for \>2 years could be considered.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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North Carolina Agriculture and Technical State University/ NRI Building
RECRUITINGKannapolis, North Carolina, 28081, United States
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