Could a natural compound in food help tame iron overload?
NCT ID NCT03453918
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This trial tests whether taking polyphenol supplements with a meal can reduce how much iron the body absorbs in people with iron overload disorders like genetic hemochromatosis and dysmetabolic iron overload syndrome. Participants eat a standardized iron-rich meal with either polyphenol or placebo capsules on separate days, and researchers measure blood iron levels afterward. The goal is to see if polyphenols, which are natural iron-chelators, could help manage iron buildup.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- polyphenols (dietary supplement)
- What this could lead to
- If polyphenols reduce iron absorption, they could become a dietary strategy to help manage iron overload conditions, potentially reducing the need for phlebotomy.
- What could go wrong
- This is a small, early-stage trial. The effect may be modest or not translate to long-term benefits, and the supplement's impact on overall iron status is uncertain.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHU Clermont-Ferrand
Clermont-Ferrand, 63003, France
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