Could a natural compound in food help tame iron overload?

NCT ID NCT03453918

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial tests whether taking polyphenol supplements with a meal can reduce how much iron the body absorbs in people with iron overload disorders like genetic hemochromatosis and dysmetabolic iron overload syndrome. Participants eat a standardized iron-rich meal with either polyphenol or placebo capsules on separate days, and researchers measure blood iron levels afterward. The goal is to see if polyphenols, which are natural iron-chelators, could help manage iron buildup.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
polyphenols (dietary supplement)
What this could lead to
If polyphenols reduce iron absorption, they could become a dietary strategy to help manage iron overload conditions, potentially reducing the need for phlebotomy.
What could go wrong
This is a small, early-stage trial. The effect may be modest or not translate to long-term benefits, and the supplement's impact on overall iron status is uncertain.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CHU Clermont-Ferrand

    Clermont-Ferrand, 63003, France

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