PHARMACOKINETICS

This study compares a new rapid-acting insulin (I004) to the approved NovoLog in 60 healthy adults. Researchers measure how fast the insulin enters the blood and how well it controls blood sugar using a special clamp technique. The goal is to show the two insulins work the same, …

This early-phase trial tests an experimental oral drug called IPG7236 in people with advanced solid tumors that have spread or cannot be removed. The study has two parts: first, finding a safe dose, then expanding to see if the drug can control tumor growth. About 196 participant…

This study tests whether a long-acting form of the numbing drug bupivacaine (liposomal bupivacaine) provides better pain relief than the standard version after minimally invasive chest surgery. Forty adults undergoing thoracoscopic procedures will receive one of the two drugs inj…

This Phase 1 trial is testing a new drug called linaprazan glurate in 121 healthy adults to see how the body absorbs and processes it, and whether it affects heart rhythm. The study is double-blind and placebo-controlled, meaning some participants get a dummy pill. It is an early…

This early-stage trial tests how a new form of oxycodone (PF614) combined with nafamostat behaves in the body. Fifty-four healthy adults will receive single doses to measure drug levels and safety. The goal is to see if this combination can reduce misuse potential while still pro…

This study looks at how the body processes kava and kratom when taken together compared to taking each one alone. It involves 18 healthy adults who will try all three options in a random order. The goal is to understand any interactions, not to treat any disease.

This study looks at how antibiotics like amoxicillin and metronidazole work in the body when used with deep cleaning for severe gum disease. Researchers want to find the best dose and treatment length (3 vs 7 days) to kill harmful bacteria without overusing antibiotics. About 45 …

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study looks at whether current antibiotic doses work well for children in intensive care. Researchers will take blood samples from 640 children receiving common antibiotics to measure drug levels. The goal is to see if these doses reach high enough concentrations to fight in…

This study looks at how antibiotics behave in the bodies of critically ill newborns, infants, and children who are on a heart-lung machine called ECMO. Researchers want to find out if current doses are high enough to fight infections without causing harm. The goal is to improve d…

This early-stage study tests a new antibiotic combination (ceftibuten-ledaborbactam) in 46 healthy adults aged 18-55. The goal is to check safety and how the drug moves through the body, not to treat any disease. Participants will stay at a clinic for several days and have follow…

This early-stage study tests whether a single inhaled dose of RCS-21 is safe and tolerable in 24 healthy volunteers aged 18 to 64. Participants receive either the drug or a placebo and are closely monitored for side effects and how the drug moves through the body. The study does …

This study looks at how smoking high-potency cannabis affects pain relief, feelings of being high, and drug levels in the blood. Researchers will test 30 near-daily cannabis users who are not seeking treatment. Participants will smoke either placebo, low-dose, or high-dose THC ca…