PHARMACOKINETICS

This study tests an experimental pill called IPG7236 in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety, find the best dose, and see if the drug can shrink or control the cancer. About 196 adults will take the pill twice…

This early-stage trial is checking if a single inhaled dose of RCS-21 is safe and tolerable in 24 healthy adults aged 18 to 64. Participants receive one dose and are closely monitored for side effects. The study does not aim to treat any disease, just to gather initial safety and…

This study tests how the body handles two different forms of evolocumab, a drug used to lower cholesterol. About 400 healthy adults aged 18 to 60 will receive a single dose and be monitored for drug levels and side effects. The goal is to compare the two versions, not to treat an…

This early-stage study tests how a new painkiller (PF614) moves through the body when taken alone or with another drug (nafamostat). Thirty healthy adults aged 18 to 55 will receive a single dose, and researchers will measure drug levels in the blood over time. The goal is to und…

This study looks at whether antibiotics given to critically ill children in the ICU reach the right levels in their blood to fight infections effectively. Researchers will measure drug concentrations after the first dose and at steady state in 640 children from newborns to age 15…

This study looks at how smoking high-potency cannabis affects pain relief and feelings of being high. Researchers will test 30 near-daily cannabis users who are not trying to quit. They will compare results when people smoke as usual and after a short break from cannabis.

This early-stage study tests a new antibiotic combination (ceftibuten-ledaborbactam etzadroxil) in about 46 healthy adults aged 18-55. The goal is to check safety and how the drug moves through the body, not to treat any disease. Results will help decide if further studies are po…

This study looks at how antibiotics work in critically ill newborns, infants, and children who are on a life-support machine called ECMO. The goal is to see if current antibiotic doses are effective and safe. Researchers will measure drug levels in the blood to find the best dosi…

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing better. The goal is to improve treatme…