New vaginal ring aims to prevent HIV and pregnancy in one device

NCT ID NCT05041699

Completed Knowledge-focused Sponsor: International Partnership for Microbicides, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a vaginal ring that slowly releases two medicines: dapivirine (to prevent HIV) and levonorgestrel (a contraceptive). Forty healthy women without HIV used the ring for 90 days. Researchers measured drug levels in blood and vaginal fluid and checked for side effects and bleeding changes. The goal was to see if the ring is safe and how the drugs are absorbed.

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Conditions

The condition(s) this trial relates to.

Hemorrhage hemorrhagic disease HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLEEDING PHARMACOKINETICS SAFETY ISSUES

Contacts and locations

Locations

Oregon Health & Science University

Portland, Oregon, 97239, United States
UPMC Magee-Womens Hospital, Center for Family Planning Research

Pittsburgh, Pennsylvania, 15213-3180, United States

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