Kidney function may affect how new antibiotic combo works
NCT ID NCT05488678
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-stage study tested how a single dose of the antibiotic combination ceftibuten/VNRX-7145 is processed by the body in 32 adults with normal or impaired kidney function, including those on dialysis. Researchers measured drug levels in the blood and monitored safety. The goal was to gather information for future dosing recommendations, not to treat an infection.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ceftibuten and VNRX-7145 (an experimental antibiotic combination)
What this could lead to
If successful, this could help doctors understand how to dose this antibiotic safely for patients with kidney problems.
What could go wrong
This is a very early, small study (32 people) focused on drug levels and safety, not on treating an infection. It may not lead to a new treatment.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Advanced Pharma
Miami, Florida, 33147, United States
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Nucleus Network
Saint Paul, Minnesota, 55114, United States
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Orlando Clinical Research Center
Orlando, Florida, 32809, United States