Supplement urolithin a tested for blood sugar boost in older adults

NCT ID NCT06274749

Recruiting now Symptom relief Sponsor: National Institute on Aging (NIA) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 35 times

Summary

This study tests whether urolithin A, a natural supplement, can improve how the body releases insulin and controls blood sugar in healthy adults aged 55 and older with a BMI of 27 or higher. Over 8 weeks, 180 participants will take either urolithin A or a placebo daily. Researchers will measure insulin and hormone responses to sugar drinks, continuous glucose monitoring, and exercise tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Urolithin A (a dietary supplement)
What this could lead to: If it works, this could point toward a simple supplement to help older adults maintain healthy blood sugar levels and reduce diabetes risk.
What could go wrong: This is an early-stage trial in healthy volunteers, so results may not apply to people with diabetes. The supplement may show no benefit over placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Insulin Resistance

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEER

Contacts and locations

Locations

National Institute of Aging, Clinical Research Unit
RECRUITING

Baltimore, Maryland, 21224, United States

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