Could an MS drug fix a brain chemical problem in schizophrenia?
NCT ID NCT06957808
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether diroximel fumarate, a drug already used for multiple sclerosis, can increase levels of the antioxidant glutathione in the brains of people with schizophrenia. Thirty participants will take the drug for two weeks, then be randomly assigned to continue the drug or switch to a placebo for another two weeks. Researchers will use brain scans and EEG to measure changes in glutathione and related brain activity.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Diroximel fumarate (also known as Vumerity)
What this could lead to
If it works, this could point toward a new treatment target for schizophrenia by increasing brain antioxidant levels.
What could go wrong
This is a very early, small study (30 people) testing a short-term effect on a brain chemical, not symptoms. The drug may not change glutathione or improve outcomes.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Department of Computer Science, Faculty of Engineering Science, University College London
RECRUITINGLondon, Greater London, WC1E 6BT, United Kingdom
Contact Email: •••••@•••••
Contact
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School of Psychology, University of birmingham
RECRUITINGBirmingham, B15 2TT, United Kingdom
Contact Email: •••••@•••••
Contact
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South London and Maudsley NHS Foundation Trust
RECRUITINGLondon, Greater London, SE58AZ, United Kingdom
Contact
Contact
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Email: •••••@•••••
Contact