Could an MS drug fix a brain chemical problem in schizophrenia?

NCT ID NCT06957808

Recruiting now Knowledge-focused Sponsor: King's College London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether diroximel fumarate, a drug already used for multiple sclerosis, can increase levels of the antioxidant glutathione in the brains of people with schizophrenia. Thirty participants will take the drug for two weeks, then be randomly assigned to continue the drug or switch to a placebo for another two weeks. Researchers will use brain scans and EEG to measure changes in glutathione and related brain activity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Diroximel fumarate (also known as Vumerity)
What this could lead to: If it works, this could point toward a new treatment target for schizophrenia by increasing brain antioxidant levels.
What could go wrong: This is a very early, small study (30 people) testing a short-term effect on a brain chemical, not symptoms. The drug may not change glutathione or improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Inflammation Psychotic Disorders schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHRENIA DISORDERS

Contacts and locations

Locations

Department of Computer Science, Faculty of Engineering Science, University College London
RECRUITING

London, Greater London, WC1E 6BT, United Kingdom
School of Psychology, University of birmingham
RECRUITING

Birmingham, B15 2TT, United Kingdom
South London and Maudsley NHS Foundation Trust
RECRUITING

London, Greater London, SE58AZ, United Kingdom

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