Which biopsy method best spots early esophageal cancer?
NCT ID NCT05530343
First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This trial compares two ways to sample tissue in people with Barrett's esophagus, a condition that raises the risk of esophageal cancer. The standard method takes four small tissue samples every 2 centimeters, while the newer method uses a brush to collect cells over a wider area. The study aims to see which approach better detects precancerous changes or early cancer. About 2,300 participants will undergo both methods during endoscopy, with the order randomly assigned.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If one method proves superior, it could become the new standard for detecting early esophageal cancer, potentially saving lives through earlier treatment.
- What could go wrong
- The trial compares two already accepted methods, so the difference may be small. Results depend on confirmation biopsies, and the benefit may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Arizona Centers of Digestive Health
RECRUITINGGilbert, Arizona, 85295, United States
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Connecticut Clinical Research Institute
RECRUITINGBristol, Connecticut, 06010, United States
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Gastrointestinal Associates, PC
RECRUITINGKnoxville, Tennessee, 37909, United States
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Geisinger Medical Center
RECRUITINGDanville, Pennsylvania, 17822, United States
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Kaiser Permanente
RECRUITINGOakland, California, 94611, United States
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Long Island Jewish Medical Center
RECRUITINGNew Hyde Park, New York, 11040, United States
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Suncoast Endoscopy of Sarasota
RECRUITINGSarasota, Florida, 34239, United States
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UCLA / Jonsson Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90024, United States
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University of Colorado Anschutz Medical Campus
RECRUITINGAurora, Colorado, 80045, United States
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University of North Carolina at Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27599, United States
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University of Rochester
RECRUITINGRochester, New York, 14642, United States
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Weill Cornell Medicine
RECRUITINGNew York, New York, 10065, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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