Can a swallowed balloon unlock the genetic secrets of esophageal cancer?

NCT ID NCT00288119

Recruiting now Knowledge-focused Sponsor: Case Western Reserve University Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This research study is investigating how genetics and environmental factors contribute to the development of Barrett's esophagus and esophageal adenocarcinoma, a type of cancer. Researchers will collect samples from the esophagus using a non-endoscopic balloon capsule device, which is swallowed and then inflated to gather cells. The study includes adults and children with Barrett's esophagus, esophageal cancer, or a family history of these conditions. The goal is to better understand the biological changes that lead to cancer and to improve detection and risk assessment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Balloon capsule device for esophageal sampling
What this could lead to: If successful, this could lead to better ways to detect and predict progression of Barrett's esophagus to cancer, potentially improving prevention and treatment strategies.
What could go wrong: This is an observational study, so it won't directly test a treatment. The balloon device may not be as accurate as endoscopy, and results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Barrett esophagus esophageal adenocarcinoma Esophageal Neoplasms neoplasm of esophagus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BARRETT'S ESOPHAGUS ESOPHAGEAL NEOPLASM

Contacts and locations

Locations

Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Fred Hutchinson Cancer Research Center, UWMC
RECRUITING

Seattle, Washington, 98109, United States
Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21205, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
University Hospitals of Cleveland
RECRUITING

Cleveland, Ohio, 44106-8066, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
VA Puget Sound Health Care System
RECRUITING

Seattle, Washington, 98108, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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